{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:47:50Z","timestamp":1791582470823,"version":"4.3.4"},"reference-count":35,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Medical Sciences and Nutrition"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Background: The expression of selenium-binding protein 1 (SELENBP1), a molecule responsible for the absorption of selenium in the colon, is crucial for its immunoregulatory effect, but this phenomenon has not been studied in patients with UC. The present study aimed to determine the clinical outcome of SELENBP1 expression in colonic tissue from patients with UC. Methods: The relative mRNA expression of SELENBP1 was analyzed in 34 patients with UC and 20 controls. Statistical analyses were performed with SPSS 19. Results: SELENBP1 gene expression was significantly lower in patients with active UC than those with UC in remission (p = 0.003) and within the controls (p = 0.04). Overexpression of the SELENBP1 gene was associated with a more benign clinical course characterized by initial activity and more than two years of prolonged remission (OR 23.7, p = 0.003) and an intermittent clinical course (OR 47.5, p = 0.001), mild histological activity (OR 0.11; 95% CI: 1.00\u20131.41, p = 0.05) and severe histological activity (OR 0.08, 95% CI: 0.008\u20130.866, p = 0.02). SELENBP1-positive cells were found mainly in the submucosa\u2019s inflammatory infiltrate and muscular and adventitia\u2019s internal layers from patients with active UC compared to those in the control group (p \u2264 0.001). Conclusions: The upregulation of SELENBP1 was associated with a benign clinical course of UC. This is the first report suggesting the immunoregulatory role of SELENBP1 in patients with UC.<\/jats:p>","DOI":"10.3390\/metabo14120662","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T10:52:30Z","timestamp":1733223150000},"page":"662","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Protective Role of Selenium-Binding Protein 1 (SELENBP1) in Patients with Ulcerative Colitis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-2596","authenticated-orcid":false,"given":"Gabriela","family":"Fonseca-Camarillo","sequence":"first","affiliation":[{"name":"Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Salvador Zubir\u00e1n, Mexico City 14080, CP, Mexico"},{"name":"Department of Immunology, Instituto Nacional de Cardiolog\u00eda, Ignacio Ch\u00e1vez, Mexico City 14080, CP, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-7221","authenticated-orcid":false,"given":"Janette","family":"Furuzawa-Carballeda","sequence":"additional","affiliation":[{"name":"Department of Experimental Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, CP, Mexico"},{"name":"Medicine School, Universidad Panamericana, Mexico City 03920, CP, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel A.","family":"Priego-Ranero","sequence":"additional","affiliation":[{"name":"Department of Clinical Cardiology, Instituto Nacional de Cardiolog\u00eda, Ignacio Ch\u00e1vez, Mexico City 14080, CP, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Barreto-Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, CP, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braulio","family":"Mart\u00ednez-Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, CP, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5247-5812","authenticated-orcid":false,"given":"Jes\u00fas K.","family":"Yamamoto-Furusho","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Salvador Zubir\u00e1n, Mexico City 14080, CP, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"F1000 Faculty Rev-294","DOI":"10.12688\/f1000research.20805.1","article-title":"Ulcerative colitis: Recent advances in the understanding of disease pathogenesis","volume":"9","author":"Porter","year":"2020","journal-title":"F1000Research"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.3748\/wjg.v16.i12.1442","article-title":"Role of diet in the management of inflammatory bowel disease","volume":"16","author":"Rajendran","year":"2010","journal-title":"World J. 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