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However, the role and molecular characterization of GLM in pancreatic cancer (PC) remain unclear. Methods: A pan-cancer analysis of glycerolipid metabolism-related genes (GMRGs) was first conducted to assess copy-number variants, single-nucleotide variations, methylation, and mRNA expression. Subsequently, GLM in PC was characterized using lipidomics, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomic analysis. A cluster analysis based on bulk RNA sequencing data from 930 PC samples identified GLM-associated subtypes, which were then analyzed for differences in prognosis, biological function, immune microenvironment, and drug sensitivity. To prioritize prognostically relevant GMRGs in PC, we employed a random forest (RF) algorithm to rank their importance across 930 PC samples. Finally, the key biomarker of PC was validated using PCR and immunohistochemistry. Results: Pan-cancer analysis identified molecular features of GMRGs in cancers, while scRNA-seq, spatial transcriptomics, and lipidomics highlighted GLM heterogeneity in PC. Two GLM-associated subtypes with significant prognostic, biofunctional, immune microenvironmental, and drug sensitivity differences were identified in 930 PC samples. Finally, ALDH2 was identified as a novel prognostic biomarker in PC and validated in a large number of datasets and clinical samples. Conclusions: This study highlights the crucial role of GLM in PC and defines a new PC subtype and prognostic biomarker. These findings establish a novel avenue for studying prognostic prediction and precision medicine in PC patients.<\/jats:p>","DOI":"10.3390\/metabo15030207","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T10:43:51Z","timestamp":1742294631000},"page":"207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multi-Omics Profiling Reveals Glycerolipid Metabolism-Associated Molecular Subtypes and Identifies ALDH2 as a Prognostic Biomarker in Pancreatic Cancer"],"prefix":"10.3390","volume":"15","author":[{"given":"Jifeng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China"},{"name":"Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China"},{"name":"Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreas, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China"},{"name":"Institute of Integrative Medicine, Dalian Medical University, Dalian 116000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China"},{"name":"Institute of Integrative Medicine, Dalian Medical University, Dalian 116000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunshu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China"},{"name":"Institute of Integrative Medicine, Dalian Medical University, Dalian 116000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3639-3363","authenticated-orcid":false,"given":"Peiyuan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China"},{"name":"Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China"},{"name":"Institute of Integrative Medicine, Dalian Medical University, Dalian 116000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China"},{"name":"Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China"},{"name":"Institute of Integrative Medicine, Dalian Medical University, Dalian 116000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.ijsu.2015.04.093","article-title":"Metastases of pancreatic adenocarcinoma: A systematic review of literature and a new functional concept","volume":"21","author":"Ruggiero","year":"2015","journal-title":"Int. J. Surg."},{"key":"ref_2","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA A Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.bbcan.2018.02.001","article-title":"Molecular classification as prognostic factor and guide for treatment decision of pancreatic cancer","volume":"1869","author":"Birnbaum","year":"2018","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1200\/JCO.21.01604","article-title":"Overall Survival Results from the POLO Trial: A Phase III Study of Active Maintenance Olaparib Versus Placebo for Germline BRCA-Mutated Metastatic Pancreatic Cancer","volume":"40","author":"Kindler","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.aan6733","article-title":"Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade","volume":"357","author":"Le","year":"2017","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13045-020-00958-3","article-title":"Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma","volume":"13","author":"Qian","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41568-021-00378-6","article-title":"Cancer metabolism: Looking forward","volume":"21","author":"Chandel","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1158\/2159-8290.CD-20-1211","article-title":"Metabolic Codependencies in the Tumor Microenvironment","volume":"11","author":"Dey","year":"2021","journal-title":"Cancer Discov."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.trecan.2020.10.004","article-title":"Fat and Furious: Lipid Metabolism in Antitumoral Therapy Response and Resistance","volume":"7","author":"Bacci","year":"2021","journal-title":"Trends Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40880-018-0301-4","article-title":"Lipid metabolism reprogramming and its potential targets in cancer","volume":"38","author":"Cheng","year":"2018","journal-title":"Cancer Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12943-017-0646-3","article-title":"Emerging roles of lipid metabolism in cancer metastasis","volume":"16","author":"Luo","year":"2017","journal-title":"Mol. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41571-020-0333-y","article-title":"Tissue-resident memory T cells in breast cancer control and immunotherapy responses","volume":"17","author":"Byrne","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.addr.2020.07.013","article-title":"Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention","volume":"159","author":"Butler","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.tem.2019.11.005","article-title":"Role of Lipoproteins in the Microenvironment of Hormone-Dependent Cancers","volume":"31","author":"Gomaraschi","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.bbalip.2014.01.009","article-title":"Chemical modulation of glycerolipid signaling and metabolic pathways","volume":"1841","author":"Scott","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_17","first-page":"4112","article-title":"Lipid droplet and its implication in cancer progression","volume":"10","author":"Li","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"eabo0264","DOI":"10.1126\/scisignal.abo0264","article-title":"Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity","volume":"15","author":"Cooke","year":"2022","journal-title":"Sci. Signal."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/dom.13008","article-title":"Monoacylglycerol signalling and ABHD6 in health and disease","volume":"19","author":"Poursharifi","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pharmthera.2017.02.033","article-title":"Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling","volume":"175","author":"Grabner","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.pharmtox.011008.145616","article-title":"Lipid mediators in health and disease: Enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation","volume":"49","author":"Shimizu","year":"2009","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Guan, H., Chen, X., Liu, J., Sun, J., Guo, H., Jiang, Y., Zhang, H., Zhang, B., Lin, J., and Yuan, Q. (2023). Molecular characteristics and therapeutic implications of Toll-like receptor signaling pathway in melanoma. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-38850-y"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41422-019-0195-y","article-title":"Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma","volume":"29","author":"Peng","year":"2019","journal-title":"Cell Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chen, J., Yuan, Q., Guan, H., Cui, Y., Fu, C., Wei, T., and Liu, K. (2024). Unraveling the role of ADAMs in clinical heterogeneity and the immune microenvironment of hepatocellular carcinoma: Insights from single-cell, spatial transcriptomics, and bulk RNA sequencing. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1461424"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s12672-024-01126-6","article-title":"Angiogenesis related genes based prognostic model of glioma patients developed by multi-omics approach","volume":"15","author":"Liu","year":"2024","journal-title":"Discov. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: Single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1016\/j.csbj.2021.06.043","article-title":"UCell: Robust and scalable single-cell gene signature scoring","volume":"19","author":"Andreatta","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Foroutan, M., Bhuva, D.D., Lyu, R., Horan, K., Cursons, J., and Davis, M.J. (2018). Single sample scoring of molecular phenotypes. BMC Bioinform., 19.","DOI":"10.1186\/s12859-018-2435-4"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-4939-7027-8_7","article-title":"Extracting the Strongest Signals from Omics Data: Differentially Expressed Pathways and Beyond","volume":"1613","author":"Glazko","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41587-019-0392-8","article-title":"Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas","volume":"38","author":"Moncada","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: Towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.talanta.2018.09.021","article-title":"Development of a metabolic pathway-based pseudo-targeted metabolomics method using liquid chromatography coupled with mass spectrometry","volume":"192","author":"Xu","year":"2019","journal-title":"Talanta"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Chen, D.-T., Davis-Yadley, A.H., Huang, P.-Y., Husain, K., Centeno, B.A., Permuth-Wey, J., Pimiento, J.M., and Malafa, M. (2015). Prognostic Fifteen-Gene Signature for Early Stage Pancreatic Ductal Adenocarcinoma. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133562"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1158\/1078-0432.CCR-13-0209","article-title":"Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer","volume":"19","author":"Zhang","year":"2013","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Zhang, G., Schetter, A., He, P., Funamizu, N., Gaedcke, J., Ghadimi, B.M., Ried, T., Hassan, R., Yfantis, H.G., and Lee, D.H. (2012). DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0031507"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1158\/0008-5472.CAN-15-2841","article-title":"A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2","volume":"76","author":"Yang","year":"2016","journal-title":"Cancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2018.08.033","article-title":"Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features","volume":"155","author":"Puleo","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zhong, L., Yang, X., Shang, Y., Yang, Y., Li, J., Liu, S., Zhang, Y., Liu, J., and Jiang, X. (2024). Exploring the pathogenesis, biomarkers, and potential drugs for type 2 diabetes mellitus and acute pancreatitis through a comprehensive bioinformatic analysis. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1405726"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Huang, R., Lu, T.L., and Zhou, R. (2023). Identification and immune landscape analysis of fatty acid metabolism genes related subtypes of gastric cancer. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-47631-6"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Maeser, D., Gruener, R.F., and Huang, R.S. (2021). oncoPredict: An R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data. Brief. Bioinform., 22.","DOI":"10.1093\/bib\/bbab260"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1097\/JTO.0b013e318233d835","article-title":"Random Survival Forests","volume":"6","author":"Taylor","year":"2011","journal-title":"J. Thorac. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s40537-023-00844-y","article-title":"BEST: A web application for comprehensive biomarker exploration on large-scale data in solid tumors","volume":"10","author":"Liu","year":"2023","journal-title":"J. Big Data"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cell.2013.03.008","article-title":"Interplay between the cancer genome and epigenome","volume":"153","author":"Shen","year":"2013","journal-title":"Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.cell.2023.02.014","article-title":"Pancreatic cancer: Advances and challenges","volume":"186","author":"Halbrook","year":"2023","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.cmet.2022.09.023","article-title":"The role of lipids in cancer progression and metastasis","volume":"34","author":"Bigas","year":"2022","journal-title":"Cell Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1053\/j.gastro.2024.01.028","article-title":"Transcriptomic-Based Microenvironment Classification Reveals Precision Medicine Strategies for Pancreatic Ductal Adenocarcinoma","volume":"166","author":"George","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.bbadis.2018.09.033","article-title":"Aldehyde dehydrogenase 2 deficiency promotes atherosclerotic plaque instability through accelerating mitochondrial ROS-mediated vascular smooth muscle cell senescence","volume":"1865","author":"Zhu","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zhong, S., Li, L., Liang, N., Zhang, L., Xu, X., Chen, S., and Yin, H. (2021). Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver. Redox Biol., 41.","DOI":"10.1016\/j.redox.2021.101919"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2174\/1874467214666210120152140","article-title":"Protective Effects of Antrodia cinnamomea and Its Constituent Compound Dehydroeburicoic Acid 32 Against Alcoholic Fatty Liver Disease","volume":"14","author":"Xu","year":"2021","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/nutrit\/nuac100","article-title":"Effects of the genetic variants of alcohol-metabolizing enzymes on lipid levels in Asian populations: A systematic review and meta-analysis","volume":"81","author":"Luo","year":"2023","journal-title":"Nutr. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jhep.2019.06.018","article-title":"ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles","volume":"71","author":"Seo","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Lei, H., Liao, J., Wang, X., Huang, R., Ying, C., and Yang, J. (2024). ALDH2 is a novel biomarker and exerts an inhibitory effect on melanoma. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-54084-y"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.csbj.2023.02.045","article-title":"ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis","volume":"21","author":"Tran","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/15\/3\/207\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:48:46Z","timestamp":1768204126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/15\/3\/207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":55,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["metabo15030207"],"URL":"https:\/\/doi.org\/10.3390\/metabo15030207","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]}}}