{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:05:44Z","timestamp":1760058344213,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"College of Physical Edu-cation and Sports PALESTRA GAPA Foundation","award":["W\/VSP\/22\/1\/I (2022_2027)"],"award-info":[{"award-number":["W\/VSP\/22\/1\/I (2022_2027)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Background: Aging is associated with the development of various disorders, including postural imbalance, which increases the risk of falls and related health complications. This study examines changes in static postural balance after a 4-week intervention involving appropriate exercise and an optimized daily regimen. Additionally, it explores the relationship between these changes and the steroidome. Methods: The study was conducted on a clinically homogeneous group of 41 females around their sixth decade, diagnosed with anxiety-depressive syndrome and treated with selective serotonin reuptake inhibitors (SSRIs). Postural balance was assessed using the dual-scales method (DLLL-DSM), which estimates postural imbalance by evaluating differences in the lower limb load in the standing position. Correlations between initial DLLL-DSM values, age, BMI, and the baseline levels of nine serum steroids, as well as post-intervention changes in five steroids, were analyzed using multivariate regression (OPLS model). Results: A significant reduction in lower limb load differences (-\u0394DLLL-DSM), indicating improved postural balance, was observed. The -\u0394DLLL-DSM strongly correlated with initial DLLL-DSM values, age, BMI, initial levels of nine serum steroids, and post-intervention changes in five steroids (R = 0.892, p &lt; 0.001). Furthermore, initial DLLL-DSM values negatively correlated with adrenal androgen androstenediol sulfate and various sulfated 5\u03b1\/\u03b2-reduced androgen metabolites (R = 0.323, p &lt; 0.05), suggesting that the activity of steroid sulfotransferase (SULT2A1) and C17-hydroxylase-C17,20-lyase (CYP17A1) at the lyase step is negatively associated with postural imbalance in elderly females. Conclusions: The findings suggest that even severe postural imbalance can be effectively and relatively rapidly improved through an appropriate exercise-based intervention and an optimized daily regimen, provided that initial adrenal activity is not significantly impaired. Additionally, the identified associations between steroid levels and postural balance provide new insights into the hormonal mechanisms regulating balance control in older individuals.<\/jats:p>","DOI":"10.3390\/metabo15040239","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T11:08:40Z","timestamp":1743505720000},"page":"239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Steroids Static Postural Balance Changes After Exercise Intervention Correlate with Steroidome in Elderly Female"],"prefix":"10.3390","volume":"15","author":[{"given":"Zuzanna","family":"Kornatovsk\u00e1","sequence":"first","affiliation":[{"name":"Department of Education, Faculty of Education, University of South Bohemia in Ceske Budejovice, Jeronymova 10, 37115 Ceske Budejovice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1705-0835","authenticated-orcid":false,"given":"Martin","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Steroid Hormones and Proteofactors, Institute of Endocrinology, 11694 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dobroslava","family":"Jandov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, College of Physical Education and Sports PALESTRA, 19700 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8170-4178","authenticated-orcid":false,"given":"Milada","family":"Krej\u010d\u00ed","sequence":"additional","affiliation":[{"name":"Department of Wellness and Nutrition Science, College of Physical Education and Sports PALESTRA, 19700 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4284-8697","authenticated-orcid":false,"given":"Anna","family":"Zwierzchowska","sequence":"additional","affiliation":[{"name":"Institute of Sport Science, Academy of Physical Education in Katowice, ul Miko\u0142owska 72a, 40-066 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/brain\/121.3.505","article-title":"Training improves the speed of aimed movements in Parkinson\u2019s disease","volume":"121","author":"Platz","year":"1998","journal-title":"Brain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1007\/s40279-017-0747-6","article-title":"Effects of supervised vs. unsupervised training programs on balance and muscle strength in older adults: A systematic review and meta-analysis","volume":"47","author":"Lacroix","year":"2017","journal-title":"Sports Med."},{"key":"ref_3","first-page":"120","article-title":"Theory of health, movement and lifestyle of human beings","volume":"8","author":"Mueller","year":"2018","journal-title":"Hung. 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