{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:16:17Z","timestamp":1790680577222,"version":"4.1.0"},"reference-count":150,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T00:00:00Z","timestamp":1743897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Emerging research suggests that the intrauterine environment plays a critical role in predisposing individuals to metabolic syndrome (MetS), a constellation of conditions that heightens the risk for heart disease, stroke, and diabetes. Traditionally linked to lifestyle, the risk for MetS is now understood to be also influenced by fetal exposures. The environment in which a child lives offers abundant potential sources that can contribute to an increased risk of developing various diseases, and in some cases, these factors can be avoided. This review integrates findings from both epidemiological and experimental research to underscore the impact of prenatal factors, including maternal nutrition, obesity, gestational diabetes (GDM), and birth size, on the subsequent development of metabolic derangements in offspring, particularly during puberty. The progression of genetic and epigenetic studies has enlightened the pathophysiology of these conditions starting in the intrauterine period and continuing into early life. By examining data and studies, this article elucidates the prenatal influences and underlying mechanisms that contribute to the pathogenesis of MetS. The updated understanding of the link between the intrauterine environment and future health comorbidities will draw attention to intrauterine care and maternal health and contribute to the prevention of serious diseases in adulthood.<\/jats:p>","DOI":"10.3390\/metabo15040252","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T10:06:28Z","timestamp":1744020388000},"page":"252","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Role of the Intrauterine Environment in Shaping Childhood and Adolescence Metabolic Outcomes"],"prefix":"10.3390","volume":"15","author":[{"given":"Asli Derya","family":"Kardelen","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, T\u00fcrkiye"},{"name":"Department of Genetics, Institute of Graduate Studies in Health Science, Istanbul University, Istanbul 34093, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza","family":"Darendeliler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"DeBoer, M.D. (2019). Assessing and Managing the Metabolic Syndrome in Children and Adolescents. Nutrients, 11.","DOI":"10.3390\/nu11081788"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s13679-019-00357-x","article-title":"Metabolic Syndrome in Children and Adolescents: Diagnostic Criteria, Therapeutic Options and Perspectives","volume":"8","author":"Weihe","year":"2019","journal-title":"Curr. Obes. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Orsini, F.D., Ambrosio, F., Scardigno, A., Ricciardi, R., and Calabr\u00f2, G.E. (2023). Epidemiological Impact of Metabolic Syndrome in Overweight and Obese European Children and Adolescents: A Systematic Literature Review. Nutrients, 15.","DOI":"10.3390\/nu15183895"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.amjcard.2010.02.017","article-title":"Relation of C-reactive protein to abdominal adiposity","volume":"106","author":"Brooks","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Paley, C.A., and Johnson, M.I. (2018). Abdominal obesity and metabolic syndrome: Exercise as medicine?. BMC Sports Sci. Med. Rehabil., 10.","DOI":"10.1186\/s13102-018-0097-1"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"GBD 2015 Obesity Collaborators, Afshin, A., Forouzanfar, M.H., Reitsma, M.B., Sur, P., Estep, K., Lee, A., Marczak, L., Mokdad, A.H., and Moradi-Lakeh, M. (2017). Health Effects of Overweight and Obesity in 195 Countries over 25 Years. N. Engl. J. Med., 377, 13\u201327.","DOI":"10.1056\/NEJMoa1614362"},{"key":"ref_7","unstructured":"GBD 2015 Risk Factors Collaborators (2016). Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990\u20132015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet, 388, 1659\u20131724."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3109\/17477160802596171","article-title":"Tracking of obesity and physical activity from childhood to adulthood: The Physical Activity Longitudinal Study","volume":"4","author":"Herman","year":"2009","journal-title":"Int. J. Pediatr. Obes."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Iafusco, D., Franceschi, R., Maguolo, A., Guercio Nuzio, S., Crin\u00f2, A., Delvecchio, M., Iughetti, L., Maffeis, C., Calcaterra, V., and Manco, M. (2023). From Metabolic Syndrome to Type 2 Diabetes in Youth. Children, 10.","DOI":"10.3390\/children10030516"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/01.med.0000436414.90240.2c","article-title":"Metabolic syndrome in young people","volume":"21","author":"Poyrazoglu","year":"2014","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1530\/EJE-21-0238","article-title":"The metabolic syndrome in pediatrics: Do we have a reliable definition? A systematic review","volume":"185","author":"Tropeano","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archpedi.157.8.821","article-title":"Prevalence of a metabolic syndrome phenotype in adolescents: Findings from the third National Health and Nutrition Examination Survey, 1988\u20131994","volume":"157","author":"Cook","year":"2003","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1161\/01.CIR.0000145117.40114.C7","article-title":"Prevalence of the metabolic syndrome in American adolescents: Findings from the Third National Health and Nutrition Examination Survey","volume":"110","author":"Gauvreau","year":"2004","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1056\/NEJMoa031049","article-title":"Obesity and the metabolic syndrome in children and adolescents","volume":"350","author":"Weiss","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1210\/jc.2003-031188","article-title":"The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity","volume":"89","author":"Cruz","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1399-5448.2007.00271.x","article-title":"The metabolic syndrome in children and adolescents\u2014An IDF consensus report","volume":"8","author":"Zimmet","year":"2007","journal-title":"Pediatr. diabetes."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0140-6736(89)90710-1","article-title":"Weight in infancy and death from ischaemic heart disease","volume":"2","author":"Barker","year":"1989","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/bmj.298.6673.564","article-title":"Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease","volume":"298","author":"Barker","year":"1989","journal-title":"Br. Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Gluckman, P.D., Hanson, M.A., and Low, F.M. (2019). Evolutionary and developmental mismatches are consequences of adaptive developmental plasticity in humans and have implications for later disease risk. Philos. Trans. R. Soc. Lond. B. Biol. Sci., 374.","DOI":"10.1098\/rstb.2018.0109"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease","volume":"23","author":"Barker","year":"2004","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1056\/NEJMe058187","article-title":"Developmental origins of health and disease","volume":"353","author":"Gillman","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1210\/endrev\/bnad002","article-title":"International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood","volume":"44","author":"Boguszewski","year":"2023","journal-title":"Endocr. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"101260","DOI":"10.1016\/j.beem.2019.01.001","article-title":"IUGR: Genetic influences, metabolic problems, environmental associations\/triggers, current and future management","volume":"33","author":"Darendeliler","year":"2019","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.beem.2018.03.013","article-title":"Diagnosis and management of postnatal fetal growth restriction","volume":"32","author":"Giabicani","year":"2018","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2018-00083","article-title":"Children Born Small for Gestational Age: Differential Diagnosis, Molecular Genetic Evaluation, and Implications","volume":"39","author":"Finken","year":"2018","journal-title":"Endocr. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/aje\/kwk071","article-title":"Birth weight and subsequent risk of type 2 diabetes: A meta-analysis","volume":"165","author":"Harder","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0140-6736(93)91224-A","article-title":"Fetal nutrition and cardiovascular disease in adult life","volume":"341","author":"Barker","year":"1993","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/jpc.14162","article-title":"A prospective study about physical growth of children from birth to 2 years old born full- term small-for-gestational-age","volume":"55","author":"Huang","year":"2019","journal-title":"J. Paediatr. Child. Health."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2265.2008.03320.x","article-title":"Influence of birth size on body composition in early adulthood: The programming factors for growth and metabolism (PROGRAM)-study","volume":"70","author":"Leunissen","year":"2009","journal-title":"Clin. Endocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1159\/000338791","article-title":"Effect of birth size and catch-up growth on adult blood pressure and carotid intima-media thickness","volume":"77","author":"Leunissen","year":"2012","journal-title":"Horm. Res. Paediatr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1001\/jama.2009.761","article-title":"Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood","volume":"301","author":"Leunissen","year":"2009","journal-title":"JAMA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/MED.0b013e328013da6c","article-title":"Catch-up growth in small for gestational age babies: Good or bad?","volume":"14","author":"Ong","year":"2007","journal-title":"Curr. Opin. Endocrinol. Diabetes. Obes."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1210\/jc.2008-2176","article-title":"Abdominal fat partitioning and high-molecular-weight adiponectin in short children born small for gestational age","volume":"94","author":"Marcos","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1038\/sj.ijo.0802127","article-title":"Pathways from weight fluctuations to metabolic diseases: Focus on maladaptive thermogenesis during catch-up fat","volume":"26","author":"Dulloo","year":"2002","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1210\/jc.2003-031848","article-title":"Avon Longitudinal Study of Parents and Children Study Team. Opposing influences of prenatal and postnatal weight gain on adrenarche in normal boys and girls","volume":"89","author":"Ong","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/bmj.320.7240.967","article-title":"Association between postnatal catch-up growth and obesity in childhood: Prospective cohort study","volume":"320","author":"Ong","year":"2000","journal-title":"BMJ."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1007\/s00125-004-1405-8","article-title":"Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels","volume":"47","author":"Ong","year":"2004","journal-title":"Diabetologia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1365-2265.2007.03119.x","article-title":"Insulin resistance and body composition in preterm born children during prepubertal ages","volume":"68","author":"Darendeliler","year":"2008","journal-title":"Clin. Endocrinol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1467-789X.2005.00159.x","article-title":"Adiponectin: Action, regulation and association to insulin sensitivity","volume":"6","author":"Lihn","year":"2005","journal-title":"Obes. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1210\/jc.2004-0792","article-title":"Adiponectin levels in the first two years of life in a prospective cohort: Relations with weight gain, leptin levels and insulin sensitivity","volume":"89","author":"Iniguez","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1210\/jc.2003-031704","article-title":"Adiponectin levels are reduced in children born small for gestational age and are inversely related to postnatal catch-up growth","volume":"89","author":"Cianfarani","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_42","first-page":"544","article-title":"Both intrauterine growth restriction and postnatal catchup growth influence childhood serum concentrations of adiponectin","volume":"61","author":"Kihara","year":"2004","journal-title":"Clin. Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1530\/eje.1.02337","article-title":"Serum adiponectin levels, insulin resistance, and lipid profile in children born small for gestational age are affected by the severity of growth retardation at birth","volume":"156","author":"Evagelidou","year":"2007","journal-title":"Eur. J. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1365-2265.2006.02724.x","article-title":"Serum levels of adiponectin and IGFBP-1 in short children born small for gestational age","volume":"66","author":"Kamoda","year":"2007","journal-title":"Clin. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cyto.2013.04.034","article-title":"The role of leptin, soluble leptin receptor, adiponectin and visfatin in insulin sensitivity in preterm born children in prepubertal ages","volume":"64","author":"Yanni","year":"2013","journal-title":"Cytokine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1365-2265.2007.03138.x","article-title":"Insulin, adiponectin, IGFBP-1 levels and body composition in small for gestational age born non-obese children during prepubertal ages","volume":"69","author":"Sancakli","year":"2008","journal-title":"Clin. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1365-2265.1998.00476.x","article-title":"Serum concentrations of insulin, insulin-like growth factor (IGF)-I, IGF binding protein (IGFBP)-1 and -3 and growth hormone binding protein in obese children: Fasting IGFBP-1 is suppressed in normoinsulinaemic obese children","volume":"48","author":"Saitoh","year":"1998","journal-title":"Clin. Endocrinol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1203\/00006450-200201000-00014","article-title":"The somatotropic axis in short children born small for gestational age: Relation to insulin resistance","volume":"51","author":"Woods","year":"2002","journal-title":"Pediatr. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1530\/eje.1.01869","article-title":"Serum markers of GH and insulin action in 12-year-old children born small for gestational age","volume":"152","author":"Tenhola","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zhang, L., Liu, J., Gao, D., and Li, D. (2024). Role of ghrelin in promoting catch-up growth and maintaining metabolic homeostasis in small-for-gestational-age infants. Front. Pediatr., 12.","DOI":"10.3389\/fped.2024.1395571"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1210\/er.2002-0029","article-title":"Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin","volume":"25","author":"Tschop","year":"2004","journal-title":"Endocr Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yfrne.2004.03.002","article-title":"Ghrelin\u2014A hormone with multiple functions","volume":"25","author":"Korbonits","year":"2004","journal-title":"Front. Neuroendocrinol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1210\/jc.2004-1192","article-title":"Fetal insulin-like growth factor (IGF)-I, IGF-II, and ghrelin in association with birth weight and postnatal growth in monozygotic twins with discordant growth","volume":"90","author":"Gohlke","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1530\/EJE-08-0924","article-title":"Ghrelin levels are decreased in non-obese prepubertal children born large for gestational age","volume":"160","author":"Darendeliler","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1007\/s00431-020-03764-8","article-title":"Increased risk for early hypertriglyceridemia in small for gestational age preterm infants","volume":"179","author":"Rabinowicz","year":"2020","journal-title":"Eur. J. Pediatr."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Chen, B., Chen, Y., Wang, Y., Xin, Q., and Ma, D. (2024). The association between rapid growth and lipid profile: A systematic review and meta-analysis. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1353334"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1253\/circj.CJ-15-1038","article-title":"Vascular Function and Myocardial Performance Indices in Children Born Small for Gestational Age","volume":"80","author":"Faienza","year":"2016","journal-title":"Circ. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1161\/01.CIR.103.9.1264","article-title":"Impact of low birth weight and cardiovascular risk factors on endothelial function in early adult life","volume":"103","author":"Leeson","year":"2001","journal-title":"Circulation"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/ijpo.12053","article-title":"The sequence of prenatal growth restraint and post-natal catch-up growth leads to a thicker intima-media and more pre-peritoneal and hepatic fat by age 3\u20136 years","volume":"11","author":"Sebastiani","year":"2016","journal-title":"Pediatr. Obes."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/MNH.0b013e3282f9b1a5","article-title":"Nephron number, glomerular ol\u00fcme, renal disease and hypertension","volume":"17","author":"Hoy","year":"2008","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1053\/j.ajkd.2015.11.015","article-title":"Familial Factors, Low Birth Weight, and Development of ESRD: A Nationwide Registry Study","volume":"67","author":"Ruggajo","year":"2016","journal-title":"Am. J. Kidney. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00467-010-1646-3","article-title":"Ambulatory blood pressure monitoring and renal functions in term small-for-gestational age children","volume":"26","author":"Bilge","year":"2011","journal-title":"Pediatr. Nephrol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1007\/s00467-023-05958-2","article-title":"Reduced kidney function and hypertension in adolescents with low birth weight, NHANES 1999\u20132016","volume":"38","author":"Brathwaite","year":"2023","journal-title":"Pediatr. Nephrol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Derraik, J.G.B., Maessen, S.E., Gibbins, J.D., Cutfield, W.S., Lundgren, M., and Ahlsson, F. (2020). Large-for-gestational-age phenotypes and obesity risk in adulthood: A study of 195,936 women. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-58827-5"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.12688\/f1000research.26072.1","article-title":"Maternal lipid levels in pregnant women without complications indeveloping risk of large for gestational age newborns: A study of meta-analysis","volume":"9","author":"Mahindra","year":"2020","journal-title":"F1000Research"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12933-019-0935-9","article-title":"Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases","volume":"18","author":"Hang","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000509932","article-title":"Birth size as a determinant of cardiometabolic risk factors in children","volume":"93","author":"Nordman","year":"2020","journal-title":"Horm. Res. Paediatr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s00431-012-1701-0","article-title":"Birth weight and overweight\/obesityin adults: A meta-analysis","volume":"171","author":"Zhao","year":"2012","journal-title":"Eur. J. Pediatr."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Schellong, K., Schulz, S., Harder, T., and Plagemann, A. (2012). Birth weight and long-term overweight risk: Systematic review and a meta-analysis includ-ing 643,902 persons from 66 studies and 26 countries globally. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047776"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/hr.2013.33","article-title":"The associations of high birth weight with blood pressure and hypertension in later life: A systematic review and meta-analysis","volume":"36","author":"Zhang","year":"2013","journal-title":"Hypertens. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/sj.ijo.0803253","article-title":"Tracking of overweight from early childhood to adolescence in cohorts born 1988 and 1994: Overweight in a high birth weight population","volume":"30","author":"Johannsson","year":"2006","journal-title":"Int. J. Obes."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/sj.ejcn.1601881","article-title":"Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population","volume":"58","author":"Gunnarsdottir","year":"2004","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1210\/jc.2018-02044","article-title":"Exposure to Gestational Diabetes Is a Stronger Predictor of Dysmetabolic Traits in Children Than Size at Birth","volume":"104","author":"Kampmann","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"124","DOI":"10.7570\/jomes20130","article-title":"Large for Gestational Age and Obesity-Related Comorbidities","volume":"30","author":"Hong","year":"2021","journal-title":"J. Obes. Metab. Syndr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1530\/EJE-09-0697","article-title":"Adiponectin: Serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for ges- tational age","volume":"162","author":"Bueno","year":"2010","journal-title":"Eur. J. Endocrinol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/ije\/dyl210","article-title":"Differential parental weight andheight contributions to offspring birthweight and weight gain ininfancy","volume":"36","author":"Griffiths","year":"2007","journal-title":"Int. J. Epidemiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/BF03346704","article-title":"Growth factors, adiponectin, leptin and body mass index in prepubertal children born large for gestational age","volume":"34","author":"Challa","year":"2011","journal-title":"J. Endocrinol. Invest."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s12020-014-0207-0","article-title":"Comparative analysis of glucoinsulinemic markers and proinflammatory cytokines in prepubertal children born large-versus appropriate-for gestational age","volume":"47","author":"Cetin","year":"2014","journal-title":"Endocrine"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1365-2265.2008.03394.x","article-title":"Adiponectin is an indicator of insulin resistance in non-obese prepubertal children born large for gestational age (LGA) and is affected by birth weight","volume":"70","author":"Darendeliler","year":"2009","journal-title":"Clin. Endocrinol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/oby.23701","article-title":"Association of large for gestational age with cardiovascular metabolic risks: A systematic review and meta-analysis","volume":"31","author":"Zhang","year":"2023","journal-title":"Obesity"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1136\/bmj.322.7291.889","article-title":"Birth weight and childhood onset type 1 diabetes: Population based cohort study","volume":"322","author":"Stene","year":"2001","journal-title":"BMJ"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/jama.2012.39","article-title":"Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999\u20132010","volume":"307","author":"Flega","year":"2012","journal-title":"J. Am. Med. Assoc."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"436","DOI":"10.2105\/AJPH.91.3.436","article-title":"Pregnancy complications and outcomes among overweight and obese nulliparous women","volume":"91","author":"Baeten","year":"2001","journal-title":"Am. J. Public Health."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.placenta.2015.04.006","article-title":"Inflammation in maternal obesity and gestational diabetes mellitus","volume":"36","author":"Pantham","year":"2015","journal-title":"Placenta"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJM199709253371301","article-title":"Predicting obesity in young adulthood from childhood and parental obesity","volume":"337","author":"Whitaker","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1161\/HYPERTENSIONAHA.113.02671","article-title":"Childhood Cardiometabolic Outcomes of Maternal Obesity During Pregnancy The Generation R Study","volume":"63","author":"Gaillard","year":"2014","journal-title":"Hypertension"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.2337\/dc08-2077","article-title":"Fetuses of obese mothers develop insulin resistance in utero","volume":"32","author":"Catalano","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.srhc.2018.07.003","article-title":"Effects of a gestational weight gain restriction program for obese women: Sibling pairs\u2019 weight development during the first five years of life","volume":"17","author":"Claesson","year":"2018","journal-title":"Sex Reprod. Healthc."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.2047-6310.2013.00205.x","article-title":"Differences in gestational weight gain between pregnancies before and after maternal bariatric surgery correlate with differences in birth weight but not with scores on the body mass index in early childhood","volume":"9","author":"Berglind","year":"2014","journal-title":"Pediatr. Obes."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"(2018). ACOG Practice Bulletin No. 190. Gestational Diabetes Mellitus. Obstet. Gynecol., 131, e49\u2013e64.","DOI":"10.1097\/AOG.0000000000002501"},{"key":"ref_91","first-page":"685","article-title":"Diabetes and pregnancy; blood sugar of newborn infants during fasting and glucose administration","volume":"114","author":"Pedersen","year":"1952","journal-title":"Ugeskr. Laeger."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"HAPO Study Cooperative Research Group, Metzger, B.E., Lowe, L.P., Dyer, A.R., Trimble, E.R., Chaovarindr, U., Coustan, D.R., Hadden, D.R., McCance, D.R., and Hod, M. (2008). Hyperglycemia and adverse pregnancy outcomes. N. Engl. J. Med., 358, 1991\u20132002.","DOI":"10.1056\/NEJMoa0707943"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Leth-M\u00f8ller, M., Hulman, A., Kampmann, U., Hede, S., Ovesen, P.G., and Knorr, S. (2024). Effect of gestational diabetes on fetal growth rate and later overweight in the offspring. J. Clin. Endocrinol. Metab., dgae428.","DOI":"10.1210\/clinem\/dgae428"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.1464-5491.2003.00946.x","article-title":"Amniotic fluid insulin levels and fetal abdominal circumference at time of amniocentesis in pregnancies with diabetes","volume":"20","author":"Kjos","year":"2003","journal-title":"Diabet. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S2213-8587(22)00215-7","article-title":"Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: Prospective observational multinational INTERBIO-21st fetal study","volume":"10","author":"Villar","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s12020-020-02492-1","article-title":"Association between metabolic syndrome and gestational diabetes mellitus in women and their children: A systematic review and meta-analysis","volume":"71","author":"Pathirana","year":"2021","journal-title":"Endocrine"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"964","DOI":"10.2337\/dc09-1810","article-title":"Effect of treatment of gestational diabetes mellitus on obesity in the next generation","volume":"33","author":"Gillman","year":"2010","journal-title":"Diabetes Care"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2337\/dc18-2021","article-title":"Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): Maternal Glycemia and Childhood Glucose Metabolism","volume":"42","author":"Scholtens","year":"2019","journal-title":"Diabetes Care"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.2337\/dc21-2634","article-title":"Glucose Intolerance in Pregnancy and Offspring Obesity in Late Adolescence","volume":"45","author":"Bendor","year":"2022","journal-title":"Diabetes Care"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/ijo.2008.213","article-title":"Established maternal obesity in the rat reprograms hypothalamic appetite regulators and leptin signaling at birth","volume":"33","author":"Morris","year":"2009","journal-title":"Int. J. Obes."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.clinthera.2018.08.007","article-title":"Maternal Lipids and Fetal Overgrowth: Making Fat from Fat","volume":"40","author":"Barbour","year":"2018","journal-title":"Clin Ther."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.2337\/dc18-2581","article-title":"Children Exposed to Maternal Obesity or Gestational Diabetes Mellitus During Early Fetal Development Have Hypothalamic Alterations That Predict Future Weight Gain","volume":"42","author":"Page","year":"2019","journal-title":"Diabetes Care"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Ann. Rev. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.2337\/diabetes.51.7.2207","article-title":"TNF-alpha is a predictor of insulin resistance in human pregnancy","volume":"51","author":"Kirwan","year":"2002","journal-title":"Diabetes"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1210\/en.2009-0849","article-title":"Up-regulation of Toll-like receptor 4\/nuclear factor-kappaB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation","volume":"151","author":"Yan","year":"2010","journal-title":"Endocrinology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/14653240701508437","article-title":"Activated \u03b2-catenin induces myogenesis and inhibits adipogenesis in BM-derived mesenchymal stromal cells","volume":"9","author":"Shang","year":"2007","journal-title":"Cytotherapy"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1210\/en.2005-0362","article-title":"Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1\/2) mesenchymal multipotent cells","volume":"146","author":"Artaza","year":"2005","journal-title":"Endocrinology"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1210\/jc.2006-0980","article-title":"Modulation of adipokines and cytokines in gestational diabetes and macrosomia","volume":"91","author":"Grissa","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.placenta.2005.08.009","article-title":"The placenta cytokine network and inflammatory signals","volume":"27","year":"2006","journal-title":"Placenta"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.placenta.2007.12.010","article-title":"Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta","volume":"29","author":"Challier","year":"2008","journal-title":"Placenta"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.placenta.2014.01.003","article-title":"Maternal obesity is associated with a lipotoxic placental environment","volume":"35","author":"Saben","year":"2014","journal-title":"Placenta."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3109\/09513590.2012.683055","article-title":"The expression of suppressor of cytokine signaling 1 and 3 in fat and placental tissue from women with gestational diabetes","volume":"28","author":"Kuzmicki","year":"2012","journal-title":"Gynecol. Endocrinol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e1127","DOI":"10.1002\/cl2.1127","article-title":"Effects of vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low- and middle-income countries: A systematic review","volume":"17","author":"Keats","year":"2021","journal-title":"Campbell Syst. Rev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/oby.2006.151","article-title":"The importance of catch-up growth after early malnutrition for the programming of obesity in male rat","volume":"14","author":"Bieswal","year":"2006","journal-title":"Obesity"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"R2306","DOI":"10.1152\/ajpregu.00783.2006","article-title":"Programmed metabolic syndrome: Prenatal undernutrition and postweaning overnutrition","volume":"293","author":"Desai","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"368461","DOI":"10.1155\/2013\/368461","article-title":"Current thoughts on maternal nutrition and fetal programming of the metabolic syndrome","volume":"2013","author":"Brenseke","year":"2013","journal-title":"J. Pregnancy."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"E1101","DOI":"10.1152\/ajpendo.2001.281.5.E1101","article-title":"Glucose uptake and glucose transporter proteins in skeletal muscle from undernourished rats","volume":"281","author":"Agote","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1210\/en.2004-1658","article-title":"Maternal food restriction enhances insulin-induced GLUT-4 translocation and insulin signaling pathway in skeletal muscle from suckling rats","volume":"146","author":"Gavete","year":"2005","journal-title":"Endocrinology"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.3390\/nu7042748","article-title":"Considering maternal dietary modulators for epigenetic regulation and programming of the fetal epigenome","volume":"7","author":"Chango","year":"2015","journal-title":"Nutrients"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"9492","DOI":"10.3390\/nu7115467","article-title":"Impact of Maternal Diet on the Epigenome during In Utero Life and the Developmental Programming of Diseases in Childhood and Adulthood","volume":"7","author":"Lee","year":"2015","journal-title":"Nutrients"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Gupta, P., Narang, M., Banerjee, B.D., and Basu, S. (2004). Oxidative stress in term small for gestational age neonates born to undernourished mothers: A case control study. BMC Pediatr., 20.","DOI":"10.1186\/1471-2431-4-14"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0188-4409(02)00356-9","article-title":"Antioxidant vitamin levels in term and preterm infants and their relation to maternal vitamin status","volume":"33","author":"Baydas","year":"2002","journal-title":"Arch. Med. Res."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Zheng, J., Liu, X., Zheng, B., Zheng, Z., Zhang, H., Zheng, J., Sun, C., Chen, H., Yang, J., and Wang, Z. (2020). Maternal 25-Hydroxyvitamin D Deficiency Promoted Metabolic Syndrome and Downregulated Nrf2\/CBR1 Pathway in Offspring. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00097"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e12672","DOI":"10.1111\/mcn.12672","article-title":"Associations of maternal and fetal vitamin D status with childhood body composition and cardiovascular risk factors","volume":"15","author":"Miliku","year":"2019","journal-title":"Matern. Child. Nutr."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11892-012-0358-4","article-title":"Role of vitamin D in the development of insulin resistance and type 2 diabetes","volume":"13","author":"Pilz","year":"2013","journal-title":"Curr. Diab. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ejcn.2013.232","article-title":"Vitamin B12: One carbon metabolism, fetal growth and programming for chronic disease","volume":"68","author":"Rush","year":"2014","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Behere, R.V., Deshmukh, A.S., Otiv, S., Gupte, M.D., and Yajnik, C.S. (2021). Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.619176"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00125-007-0793-y","article-title":"Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: The Pune Maternal Nutrition Study","volume":"51","author":"Yajnik","year":"2008","journal-title":"Diabetologia"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.3945\/jn.111.144717","article-title":"Low Maternal Vitamin B-12 Status Is Associated with Offspring Insulin Resistance Regardless of Antenatal Micronutrient Supplementation in Rural Nepal","volume":"141","author":"Stewart","year":"2011","journal-title":"J. Nutr."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e1552","DOI":"10.1542\/peds.2011-3093","article-title":"Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: A systematic review","volume":"129","author":"Davis","year":"2012","journal-title":"Pediatrics"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10654-013-9763-5","article-title":"Offspring\u2019s blood pressure and metabolic phenotype after exposure to gestational hypertension in utero","volume":"28","author":"Miettola","year":"2013","journal-title":"Eur. J. Epidemiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/00004872-200018070-00002","article-title":"The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: A systematic review of the literature","volume":"18","author":"Huxley","year":"2000","journal-title":"J. Hypertens."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bpobgyn.2011.01.006","article-title":"Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy","volume":"25","author":"Hutcheon","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-15-0309","article-title":"Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment","volume":"228","author":"Jonker","year":"2016","journal-title":"J. Endocrinol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1007\/s00246-013-0702-8","article-title":"Assessment of Fetal Cardiac Function in Mild Preeclampsia","volume":"34","author":"Balli","year":"2013","journal-title":"Pediatr. Cardiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/aje\/kww059","article-title":"Influence of Maternal Gestational Hypertensive Disorders on Microvasculature in School-Age Children: The Generation R Study","volume":"184","author":"Yesil","year":"2016","journal-title":"Am. J. Epidemiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/HYPERTENSIONAHA.111.172387","article-title":"Endothelial function and circulating biomarkers are disturbed in women and children after preeclampsia","volume":"58","author":"Kvehaugen","year":"2011","journal-title":"Hypertension"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Koulouraki, S., Paschos, V., Pervanidou, P., Christopoulos, P., Gerede, A., and Eleftheriades, M. (2023). Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature. Children, 10.","DOI":"10.3390\/children10050826"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1177\/2047487319852716","article-title":"Hypertensive disorders of pregnancy and cardiometabolic outcomes in childhood: A systematic review","volume":"26","author":"Jansen","year":"2019","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"e13411","DOI":"10.1111\/obr.13411","article-title":"Long-term effects of preeclampsia on metabolic and biochemical outcomes in offspring: What can be expected from a meta-analysis?","volume":"23","author":"Bi","year":"2022","journal-title":"Obes. Rev."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Indrio, F., Martini, S., Francavilla, R., Corvaglia, L., Cristofori, F., Mastrolia, S.A., Neu, J., Rautava, S., Russo Spena, G., and Raimondi, F. (2017). Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Long-term Health Development. Front. Pediatr., 5.","DOI":"10.3389\/fped.2017.00178"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/15592294.2019.1582277","article-title":"Nutrigenetics, epigenetics and gestational diabetes: Consequences in mother and child","volume":"14","author":"Franzago","year":"2019","journal-title":"Epigenetics"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/aje\/kwt433","article-title":"Neonatal genome-wide methylation patterns in relation to birth weight in the Norwegian Mother and Child Cohort","volume":"179","author":"Engel","year":"2014","journal-title":"Am. J. Epidemiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1007\/s00125-016-3983-7","article-title":"DNA hypermethylation of CD3(+) T cells from cord blood of infants exposed to intrauterine growth restriction","volume":"59","author":"Williams","year":"2016","journal-title":"Diabetologia"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1017\/S2040174420000422","article-title":"Circulating microRNAs overexpressed in macrosomia: An experimental and bioinformatic approach","volume":"11","year":"2020","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"e22389","DOI":"10.1097\/MD.0000000000022389","article-title":"Differences of DNA methylation patterns in the placenta of large for gestational age infant","volume":"99","author":"Shen","year":"2020","journal-title":"Medicine"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1080\/15592294.2022.2111751","article-title":"Gestational diabetes mellitus placentas exhibit epimutations at placental development genes","volume":"17","author":"Meyrueix","year":"2022","journal-title":"Epigenetics"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/2211536611666220413100636","article-title":"MicroRNA-7 Regulates Insulin Signaling Pathway by Targeting IRS1, IRS2, and RAF1 Genes in Gestational Diabetes Mellitus","volume":"11","author":"Bhushan","year":"2022","journal-title":"Microrna"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Zhang, L., Yu, X., Wu, Y., Fu, H., Xu, P., Zheng, Y., Wen, L., Yang, X., Zhang, F., and Hu, M. (2021). Gestational Diabetes Mellitus-Associated Hyperglycemia Impairs Glucose Transporter 3 Trafficking in Trophoblasts Through the Downregulation of AMP-Activated Protein Kinase. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.722024"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1542\/neo.23-6-e363","article-title":"Fetal Growth and Intrauterine Epigenetic Programming of Obesity and Cardiometabolic Disease","volume":"23","author":"Harary","year":"2022","journal-title":"Neoreviews"}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/15\/4\/252\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:11:08Z","timestamp":1760029868000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/15\/4\/252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,6]]},"references-count":150,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["metabo15040252"],"URL":"https:\/\/doi.org\/10.3390\/metabo15040252","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,6]]}}}