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Hospital","award":["2024JDKPO1117"],"award-info":[{"award-number":["2024JDKPO1117"]}]},{"name":"Projects of Deyang People\u2019s Hospital","award":["FHS202503"],"award-info":[{"award-number":["FHS202503"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Background: The composition and metabolic activity of the gut microbiota play a crucial role in various health conditions, including the occurrence and development of chronic constipation. Recent metabolomic advances reveal that gut microbiota-derived metabolites\u2014such as SCFAs, bile acids, neurotransmitters, and microbial gases\u2014play critical roles in regulating intestinal function. Methods: We systematically analyzed the current literature on microbial metabolomics in chronic constipation. This review consolidates findings from high-throughput metabolomic techniques (GC-MS, LC-MS, NMR) comparing metabolic profiles of constipated patients with healthy individuals. It also examines diagnostic improvements and personalized treatments, including fecal microbiota transplantation and neuromodulation, guided by these metabolomic insights. Results: This review shows that reduced SCFA levels impair intestinal motility and promote inflammation. An altered bile acid metabolism\u2014with decreased secondary bile acids like deoxycholic acid\u2014disrupts receptor-mediated signaling, further affecting motility. Additionally, imbalances in amino acid metabolism and neurotransmitter production contribute to neuromuscular dysfunction, while variations in microbial gas production (e.g., methane vs. hydrogen) further modulate gut transit. Conclusions: Integrating metabolomics with gut microbiota research clarifies how specific microbial metabolites regulate gut function. These insights offer promising directions for precision diagnostics and targeted therapies to restore microbial balance and improve intestinal motility.<\/jats:p>","DOI":"10.3390\/metabo15040269","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T04:42:07Z","timestamp":1744605727000},"page":"269","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Metabolomics Insights into Gut Microbiota and Functional Constipation"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6775-1664","authenticated-orcid":false,"given":"Fan","family":"Zheng","sequence":"first","affiliation":[{"name":"Deyang People\u2019s Hospital of Chengdu University of Traditional Chinese Medicine, Deyang 617000, China"},{"name":"School of Medical Sciences, University Sains Malaysia, Kota Bharu 16150, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[{"name":"Deyang People\u2019s Hospital of Chengdu University of Traditional Chinese Medicine, Deyang 617000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-8687","authenticated-orcid":false,"given":"Guanting","family":"Lu","sequence":"additional","affiliation":[{"name":"Deyang People\u2019s Hospital of Chengdu University of Traditional Chinese Medicine, Deyang 617000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Shun","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Industrial Technology, University Sains Malaysia, Penang 11700, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Mageswary","sequence":"additional","affiliation":[{"name":"School of Industrial Technology, University Sains Malaysia, Penang 11700, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhan","sequence":"additional","affiliation":[{"name":"Anorectal Department, Chengdu Integrated TCM & Western Medicine Hospital, Chengdu 610000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5386-1985","authenticated-orcid":false,"given":"Mina Ehab","family":"Ayad","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University Sains Malaysia, Kota Bharu 16150, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-7717","authenticated-orcid":false,"given":"Yeong-Yeh","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University Sains Malaysia, Kota Bharu 16150, Malaysia"},{"name":"GI Function and Motility Unit, Hospital Pakar University Sains Malaysia, Kota Bharu 16150, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5375-2664","authenticated-orcid":false,"given":"Daoyuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Deyang People\u2019s Hospital of Chengdu University of Traditional Chinese Medicine, Deyang 617000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/j.gastro.2019.12.034","article-title":"Mechanisms, Evaluation, and Management of Chronic Constipation","volume":"158","author":"Bharucha","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/ajg.2014.187","article-title":"American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation","volume":"109","author":"Ford","year":"2014","journal-title":"Am. 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