{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:11:45Z","timestamp":1790640705548,"version":"4.1.0"},"reference-count":114,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Federal Government of Mexico","award":["482874"],"award-info":[{"award-number":["482874"]}]},{"name":"Federal Government of Mexico","award":["IN220820"],"award-info":[{"award-number":["IN220820"]}]},{"name":"Federal Government of Mexico","award":["HIM-2021-049"],"award-info":[{"award-number":["HIM-2021-049"]}]},{"DOI":"10.13039\/501100005739","name":"UNAM","doi-asserted-by":"publisher","award":["482874"],"award-info":[{"award-number":["482874"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005739","name":"UNAM","doi-asserted-by":"publisher","award":["IN220820"],"award-info":[{"award-number":["IN220820"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005739","name":"UNAM","doi-asserted-by":"publisher","award":["HIM-2021-049"],"award-info":[{"award-number":["HIM-2021-049"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009609","name":"federal funds","doi-asserted-by":"publisher","award":["482874"],"award-info":[{"award-number":["482874"]}],"id":[{"id":"10.13039\/501100009609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009609","name":"federal funds","doi-asserted-by":"publisher","award":["IN220820"],"award-info":[{"award-number":["IN220820"]}],"id":[{"id":"10.13039\/501100009609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009609","name":"federal funds","doi-asserted-by":"publisher","award":["HIM-2021-049"],"award-info":[{"award-number":["HIM-2021-049"]}],"id":[{"id":"10.13039\/501100009609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>MicroRNAs (miRs) are epigenetic regulators of several metabolic diseases, including gestational diabetes mellitus (GDM). Objectives: Following a systematic review, we propose a pattern of key circulating miRs associated with placental changes and their potential role in the fetus. Methods: A systematic investigation of studies published between January 2011 and July 2024 was conducted in the PubMed, ScienceDirect, Trip Database, and Wiley databases. A total of 90 articles were analyzed. Results: Two hundred twenty-six circulating microRNAs were identified in women with GDM, and fifty miRs were validated by PCR, with miRs-16-5p, -29a-5p, and -195-5p being the most frequently reported. Interestingly, miR-16-5p was also expressed in the placenta but not in umbilical cord blood or amniotic fluid. Conversely, miR-126-3p was expressed in circulation, the placenta, umbilical cord blood, and amniotic fluid. Several reports describe high expression levels of miR-518d in maternal circulation, umbilical cord blood, and placenta. Controversial results regarding the expression of miR-29a-3p, -137, and -148a-3p were identified when comparing umbilical cord blood and the placenta. Conclusions: In silico analyses suggest that the miR-29 family, as well as miRs-16-5p, -126-3p, -195-5p, and -518b, may be involved in alterations in the heart, brain, and kidneys in the embryo when exposed to a hyperglycemic environment.<\/jats:p>","DOI":"10.3390\/metabo15060367","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T03:57:18Z","timestamp":1748923038000},"page":"367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Circulating MicroRNAs Associated with Changes in the Placenta and Their Possible Role in the Fetus During Gestational Diabetes Mellitus: A Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9745-7220","authenticated-orcid":false,"given":"Ninna Leslie","family":"Trejo-Gonzalez","sequence":"first","affiliation":[{"name":"Postgraduate in Biological Sciences, National Autonomous University of Mexico, Mexico City C.P. 04510, Mexico"},{"name":"Molecular Biology Research Laboratory, Children\u2019s Hospital of Mexico Federico Gomez (HIMFG), Mexico City C.P. 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Palomar-Morales","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Mexico City C.P. 54090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3669-4185","authenticated-orcid":false,"given":"Luis Arturo","family":"Baiza-Gutman","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Biology, Morphology and Function Unit, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Mexico City C.P. 54090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5370-5771","authenticated-orcid":false,"given":"Guadalupe","family":"Diaz-Rosas","sequence":"additional","affiliation":[{"name":"Molecular Biology Research Laboratory, Children\u2019s Hospital of Mexico Federico Gomez (HIMFG), Mexico City C.P. 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8709-6727","authenticated-orcid":false,"given":"Clara","family":"Ortega-Camarillo","sequence":"additional","affiliation":[{"name":"Medical Research Unit in Biochemistry, Specialties Hospital, National Medical Center SXXI, Instituto Mexicano del Seguro Social, Mexico City C.P. 06720,  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-9927","authenticated-orcid":false,"given":"Alejandra","family":"Contreras-Ramos","sequence":"additional","affiliation":[{"name":"Molecular Biology Research Laboratory, Children\u2019s Hospital of Mexico Federico Gomez (HIMFG), Mexico City C.P. 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"ref_1","unstructured":"(2025, February 02). 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