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The need for innovative and accessible treatment options is critical. Owing to their medicinal properties, natural products, such as geopropolis, hold promise. However, the wound healing potential of the geopropolis of Melipona fasciculata, particularly in accelerating the healing of diabetic ulcers, remains unexplored. In this study, we evaluated the ability of the geopropolis of M. fasciculata to promote wound healing in diabetic mice. Methods: Geopropolis was collected, prepared as a hydroalcoholic extract, and formulated into a topical cream. Non-obese diabetic (NOD) mice with induced chronic wounds were treated with this cream daily, and wound healing was assessed through macroscopic measurements, histological analysis, cytokine quantification, and in silico molecular docking studies. Results: The results demonstrated that, compared with the control treatment, the geopropolis cream accelerated wound closure at all the analyzed time points (days 3, 7, and 14), reduced inflammatory infiltrates, and enhanced fibroblast proliferation and collagen deposition. These alterations were particularly pronounced in the final phase of healing, indicating an improvement in wound repair processes. These effects occurred without altering systemic cytokine levels, suggesting a localized treatment action. These results may be partially associated with the theoretical ability of beta-amyrin and cycloartenol to interact with human myeloperoxidase (MPO), as suggested by in silico docking analysis. Conclusions: Overall, the findings indicate that geopropolis cream could represent a viable alternative for managing diabetic ulcers, providing an effective means to enhance wound healing while remaining accessible to low-income populations.<\/jats:p>","DOI":"10.3390\/metabo15060413","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:08:39Z","timestamp":1750309719000},"page":"413","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Geopropolis from Melipona fasciculata Smith Accelerates Wound Healing in Diabetic Mice"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4999-6382","authenticated-orcid":false,"given":"Aramys Silva","family":"Reis","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade e Tecnologia, de Ci\u00eancias de Imperatriz, Universidade Federal do Maranh\u00e3o, Imperatriz 65915-240, Maranh\u00e3o, Brazil"},{"name":"Laborat\u00f3rio de Fisiopatologia e Investiga\u00e7\u00e3o Terap\u00eautica, Curso de Medicina, Centro de Ci\u00eancias de Imperatriz, Universidade Federal do Maranh\u00e3o, Imperatriz 65915-240, Maranh\u00e3o, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Carvalho","family":"de Souza","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia e Investiga\u00e7\u00e3o Terap\u00eautica, Curso de Medicina, Centro de Ci\u00eancias de Imperatriz, Universidade Federal do Maranh\u00e3o, Imperatriz 65915-240, Maranh\u00e3o, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5430-0728","authenticated-orcid":false,"given":"Guilherme Martins Gomes","family":"Fontoura","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade e Tecnologia, de Ci\u00eancias de Imperatriz, Universidade Federal do Maranh\u00e3o, Imperatriz 65915-240, Maranh\u00e3o, Brazil"},{"name":"Laborat\u00f3rio de Fisiopatologia e Investiga\u00e7\u00e3o Terap\u00eautica, Curso de Medicina, Centro de Ci\u00eancias de Imperatriz, Universidade Federal do Maranh\u00e3o, Imperatriz 65915-240, Maranh\u00e3o, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luecya Alves de Carvalho","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia e Investiga\u00e7\u00e3o Terap\u00eautica, Curso de Medicina, Centro de Ci\u00eancias de Imperatriz, Universidade Federal do Maranh\u00e3o, Imperatriz 65915-240, Maranh\u00e3o, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-9500","authenticated-orcid":false,"given":"Alberto Jorge Oliveira","family":"Lopes","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Qu\u00edmica, Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia do Maranh\u00e3o, S\u00e3o Lu\u00eds 65030-005, Maranh\u00e3o, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-9736","authenticated-orcid":false,"given":"Richard Pereira","family":"Dutra","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade e Tecnologia, de Ci\u00eancias de Imperatriz, Universidade Federal do Maranh\u00e3o, Imperatriz 65915-240, Maranh\u00e3o, Brazil"},{"name":"Laborat\u00f3rio de Qu\u00edmica de Produtos Naturais, Curso de Licenciatura em Ci\u00eancias Naturais, Centro de Ci\u00eancias de Imperatriz, Universidade Federal do Maranh\u00e3o, Imperatriz 65915-240, Maranh\u00e3o, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucilene Amorim","family":"Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal do Maranh\u00e3o, S\u00e3o Lu\u00eds 65085-580, Maranh\u00e3o, Brazil"},{"name":"Laborat\u00f3rio de Patologia e Imunoparasitologia, Universidade Federal do Maranh\u00e3o, S\u00e3o Lu\u00eds 65085-580, Maranh\u00e3o, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9865-9262","authenticated-orcid":false,"given":"Rosane Nassar Meireles","family":"Guerra","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal do Maranh\u00e3o, S\u00e3o Lu\u00eds 65085-580, Maranh\u00e3o, Brazil"},{"name":"Laborat\u00f3rio de Imunofisiologia, Universidade Federal do Maranh\u00e3o, S\u00e3o Lu\u00eds 65085-580, Maranh\u00e3o, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Nilce 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