{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:24:26Z","timestamp":1760059466491,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Background: There are known associations between periodontitis and colorectal cancer, but knowledge on the connections existing between the two are not fully understood. The aim of our study was to assess prevalence and clinical severity of periodontitis in patients with localized colorectal cancer. Secondly, the dynamics of metabolic derangements, particularly glucose metabolism, insulin resistance, and diabetes mellitus were studied as well. Methods: Diagnostic procedures included endoscopies with patohistology, laboratory exams, the insulin resistance homeostatic model assessment method (HOMA index), anthropometrics, and radiology imaging. Periodontal status was evaluated by full-mouth periodontal examination. Results: A total of 79 patients with localized colorectal carcinoma, with slight male predominance of 55.7%, and an age of 65.7 \u00b1 12.4 years participated in this study. Three-quarters of patients (73.4%; 95% CI: 63.0\u201382.2%) were diagnosed with periodontitis. Patients with periodontitis and colorectal cancer had significantly increased glucose levels (fasting and after oral glucose challenge), (both p &lt; 0.05). Also, increased values of the HOMA index were found in patients with periodontitis vs. controls (without periodontitis) and colorectal cancer; 6.38 \u00b1 5.74 vs. 3.58 \u00b1 2.6 (p = 0.012); Spearman\u2019s Rho correlation coefficient = 0.271 (p = 0.039). There were significant differences in high-density cholesterol in patients with periodontitis vs. controls, 1.41 \u00b1 0.28 vs. 1.23 \u00b1 0.35 mmol\/L (p = 0.016), but correlations were insignificant; Rho c.c. = 0.045 (p = 0.738). Conclusions: The most consorted connections between periodontitis and colorectal cancer were found among parameters of metabolic domain, especially glucose concentrations and insulin resistance. Further studies, which would include novel and emerging antidiabetic treatments and their effects on the prevention or control of both diseases, would be warranted.<\/jats:p>","DOI":"10.3390\/metabo15060414","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:08:39Z","timestamp":1750309719000},"page":"414","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin Resistance"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5154-2809","authenticated-orcid":false,"given":"Mario","family":"Zivkovic","sequence":"first","affiliation":[{"name":"Internal Medicine Clinic, Department of Gastroenterology, University Hospital \u201c Sestre Milosrdnice\u201d, Vinogradska Cesta 29, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Boban","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Health Osijek, University JJ Strossmayer Osijek, Crkvena 21, 31000 Osijek, Croatia"},{"name":"Department of Cardiology, University Clinic \u201cBonto\u201d, Radnicka Cesta 1A, 10000  Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4766-048X","authenticated-orcid":false,"given":"Domagoj","family":"Vrazic","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Zagreb, Gunduliceva 5, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Vulic","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, General Hospital Pula, Santoriova Ulica 24a, 52100 Pula, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Budimir","sequence":"additional","affiliation":[{"name":"Internal Medicine Clinic, Department of Gastroenterology, University Hospital \u201c Sestre Milosrdnice\u201d, Vinogradska Cesta 29, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Blazevic","sequence":"additional","affiliation":[{"name":"Internal Medicine Clinic, Department of Gastroenterology, University Hospital \u201c Sestre Milosrdnice\u201d, Vinogradska Cesta 29, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Vcev","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Health Osijek, University JJ Strossmayer Osijek, Crkvena 21, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Nikolic","sequence":"additional","affiliation":[{"name":"Internal Medicine Clinic, Department of Gastroenterology, University Hospital \u201c Sestre Milosrdnice\u201d, Vinogradska Cesta 29, 10000 Zagreb, Croatia"},{"name":"School of Dental Medicine, University of Zagreb, Gunduliceva 5, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"998","DOI":"10.2174\/18735592MTEx9NTk2y","article-title":"Colorectal cancer epidemiology: Recent trends and impact on outcomes","volume":"22","author":"Baidoun","year":"2021","journal-title":"Curr. 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