{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:59:33Z","timestamp":1789070373472,"version":"build-2803163510"},"reference-count":113,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Vitamin D deficiency is widespread. It increases the risk of several diseases. Therefore, researchers have long studied the factors that influence vitamin D levels in the body. These include its metabolism, catabolism, transport and binding of vitamin D to the receptor VDR. Currently, an increasing number of studies are focusing on genetic factors. Variations in vitamin D levels, including vitamin D deficiency, are under substantial genetic control. There is a reciprocity between the vitamin D system and epigenetic mechanisms. Vitamin D metabolism, on the one hand, is regulated by epigenetic mechanisms and, on the other hand, is involved in regulating epigenetic events. To appraise recent advances in nutrigenomics with its application in public health, several databases, including PubMed, Scopus and Web of Science, were investigated in detail. Nutri-epigenetics deals with the interplay between dietary components and the possible resulting changes in the epigenome. There is, therefore, great potential for the development of nutri-epigenetics. The purpose of the narrative review is to highlight the genetic aspects of vitamin D, its receptor VDR and vitamin D-related gene polymorphisms with a particular focus on vitamin D gene regulation. Particular attention is paid to the vitamin D response index.<\/jats:p>","DOI":"10.3390\/metabo15070436","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T13:06:17Z","timestamp":1751288777000},"page":"436","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nutri-Epigenetic Regulation of Vitamin D\u2014Impact on Metabolism and Biological Functions: Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6484-5462","authenticated-orcid":false,"given":"Magdalena","family":"Kowal\u00f3wka","sequence":"first","affiliation":[{"name":"Department of Bromatology, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9652-0785","authenticated-orcid":false,"given":"Ilona","family":"G\u00f3rna","sequence":"additional","affiliation":[{"name":"Department of Bromatology, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4091-7035","authenticated-orcid":false,"given":"Marta","family":"Kara\u017aniewicz-\u0141ada","sequence":"additional","affiliation":[{"name":"Department of Physical Pharmacy and Pharmacokinetics, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Kusyk","sequence":"additional","affiliation":[{"name":"Department of Bromatology, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9205-2817","authenticated-orcid":false,"given":"Juliusz","family":"Przys\u0142awski","sequence":"additional","affiliation":[{"name":"Department of Bromatology, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8291-5439","authenticated-orcid":false,"given":"S\u0142awomira","family":"Drzyma\u0142a-Czy\u017c","sequence":"additional","affiliation":[{"name":"Department of Bromatology, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s41073-019-0064-8","article-title":"SANRA\u2014A scale for the quality assessment of narrative review articles","volume":"4","author":"Baethge","year":"2019","journal-title":"Res. Integr. Peer Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3897\/folmed.62.e50204.","article-title":"Vitamin D: A Review of its Effects on Epigenetics and Gene Regulation","volume":"62","author":"Snegarova","year":"2020","journal-title":"Folia Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1079\/PNS200071","article-title":"Nutrition-hormone receptor-gene interactions: Implications for development and disease","volume":"60","author":"Dauncey","year":"2001","journal-title":"Proc. Nutr. Soc."},{"key":"ref_4","first-page":"173","article-title":"Nutrigenomics: SNPs correlated to vitamins\u2019 deficiencies","volume":"174","author":"Micheletti","year":"2023","journal-title":"Clin. Ter."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/carcin\/bgi042","article-title":"Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability\u2014Results from a dietary intake and micronucleus index survey in South Australia","volume":"26","author":"Fenech","year":"2005","journal-title":"Carcinogenesis"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mierziak, J., Kostyn, K., Boba, A., Czemplik, M., Kulma, A., and Wojtasik, W. (2021). Influence of the Bioactive Diet Components on the Gene Expression Regulation. Nutrients, 13.","DOI":"10.3390\/nu13113673"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.jpeds.2012.10.059","article-title":"A genome-wide methylation study of severe vitamin D deficiency in African American adolescents","volume":"162","author":"Zhu","year":"2013","journal-title":"J. Pediatr."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Fetahu, I.S., H\u00f6baus, J., and K\u00e1llay, E. (2014). Vitamin D and the epigenome. Front. Physiol., 5.","DOI":"10.3389\/fphys.2014.00164"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/obr.12239","article-title":"Obesity and vitamin D deficiency: A systematic review and meta-analysis","volume":"16","author":"Costa","year":"2015","journal-title":"Obes. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sergeev, I.N. (2020). Vitamin D Status and Vitamin D-Dependent Apoptosis in Obesity. Nutrients, 12.","DOI":"10.3390\/nu12051392"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wimalawansa, S.J. (2019). Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging. Biology, 8.","DOI":"10.3390\/biology8020030"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s13148-011-0021-y","article-title":"Impact of vitamin D metabolism on clinical epigenetics","volume":"2","author":"Karlic","year":"2011","journal-title":"Clin. Epigenet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.14336\/AD.2016.1021","article-title":"Vitamin D and Chronic Diseases","volume":"8","author":"Wang","year":"2017","journal-title":"Aging Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/01.SMJ.0000397893.94525.0e","article-title":"Protean manifestations of vitamin D deficiency, part 2: Deficiency and its association with autoimmune disease, cancer, infection, asthma, dermopathies, insulin resistance, and type 2 diabetes","volume":"104","author":"Bell","year":"2011","journal-title":"South. Med. J."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Aiello, G., Lombardo, M., and Baldelli, S. (2024). Exploring Vitamin D Synthesis and Function in Cardiovascular Health: A Narrative Review. Appl. Sci., 14.","DOI":"10.3390\/app14114339"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bone.2018.10.006","article-title":"The genetics of vitamin D","volume":"126","author":"Jiang","year":"2019","journal-title":"Bone"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.nu.08.070188.002111","article-title":"The role of sunlight in the cutaneous production of vitamin D3","volume":"8","author":"Webb","year":"1988","journal-title":"Annu. Rev. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kift, R., Rhodes, L.E., Farrar, M.D., and Webb, A.R. (2018). Is Sunlight Exposure Enough to Avoid Wintertime Vitamin D Deficiency in United Kingdom Population Groups?. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15081624"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/bjd.13575","article-title":"Limited exposure to ambient ultraviolet radiation and 25-hydroxyvitamin D levels: A systematic review","volume":"172","author":"Rice","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Saponaro, F., Saba, A., and Zucchi, R. (2020). An Update on Vitamin D Metabolism. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186573"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.plipres.2016.09.003","article-title":"DHCR7: A vital enzyme switch between cholesterol and vitamin D production","volume":"64","author":"Prabhu","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Delrue, C., and Speeckaert, M.M. (2023). Vitamin D and Vitamin D-Binding Protein in Health and Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054642"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/jbmr.67","article-title":"Taking vitamin D with the largest meal improves absorption and results in higher serum levels of 25-hydroxyvitamin D","volume":"25","author":"Mulligan","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1194\/jlr.R031534","article-title":"Cytochrome P450-mediated metabolism of vitamin D","volume":"55","author":"Jones","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Portales-Castillo, I., and Simic, P. (2022). PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, epigenetics and beyond. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.992666"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1177\/15353702221091982","article-title":"Regulation of 1 and 24 hydroxylation of vitamin D metabolites in the proximal tubule","volume":"247","author":"Young","year":"2022","journal-title":"Exp. Biol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrendo.2011.218","article-title":"Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism","volume":"8","author":"Quarles","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"Shimada","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chembiol.2013.12.016","article-title":"Vitamin D metabolism, mechanism of action, and clinical applications","volume":"21","author":"Bikle","year":"2014","journal-title":"Chem. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.clinbiochem.2012.10.037","article-title":"Analytical measurement and clinical relevance of vitamin D(3) C3-epimer","volume":"46","author":"Bailey","year":"2013","journal-title":"Clin. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Abouzid, M., Kara\u017aniewicz-\u0141ada, M., Pawlak, K., Burchardt, P., Kruszyna, \u0141., and G\u0142\u00f3wka, F. (2020). Measurement of plasma 25-hydroxyvitamin D2, 25-hydroxyvitamin D3 and 3-epi-25-hydroxyvitamin D3 in population of patients with cardiovascular disease by UPLC-MS\/MS method. J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 1159.","DOI":"10.1016\/j.jchromb.2020.122350"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1080\/10408398.2020.1862753","article-title":"Functional effects of vitamin D: From nutrient to immunomodulator","volume":"62","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Carlberg, C. (2018). Vitamin D Genomics: From In Vitro to In Vivo. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00250"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1080\/13543776.2016.1216547","article-title":"Vitamin D receptor 2016: Novel ligands and structural insights","volume":"26","author":"Maestro","year":"2016","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Carlberg, C. (2022). Vitamin D and Its Target Genes. Nutrients, 14.","DOI":"10.3390\/nu14071354"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1172\/JCI88887","article-title":"The vitamin D receptor: Contemporary genomic approaches reveal new basic and translational insights","volume":"127","author":"Pike","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.beem.2011.05.010","article-title":"Vitamin D receptor (VDR)-mediated actions of 1\u03b1,25(OH)2vitamin D3: Genomic and non-genomic mechanisms","volume":"25","author":"Haussler","year":"2011","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jsbmb.2004.03.084","article-title":"Structural analysis of RXR-VDR interactions on DR3 DNA","volume":"89\u201390","author":"Shaffer","year":"2004","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2174\/1389557515666150519110830","article-title":"Vitamin-D in the Immune System: Genomic and Non-Genomic Actions","volume":"15","author":"Trochoutsou","year":"2015","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Seraphin, G., Rieger, S., Hewison, M., Capobianco, E., and Lisse, T.S. (2023). The impact of vitamin D on cancer: A mini review. J. Steroid Biochem. Mol. Biol., 231.","DOI":"10.1016\/j.jsbmb.2023.106308"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Tuoresm\u00e4ki, P., V\u00e4is\u00e4nen, S., Neme, A., Heikkinen, S., and Carlberg, C. (2014). Patterns of genome-wide VDR locations. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096105"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Hii, C.S., and Ferrante, A. (2016). The Non-Genomic Actions of Vitamin D. Nutrients, 8.","DOI":"10.3390\/nu8030135"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.2174\/092986707780362871","article-title":"The ERp57\/GRp58\/1,25D3-MARRS receptor: Multiple functional roles in diverse cell systems","volume":"14","author":"Khanal","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Mavar, M., Sori\u0107, T., Bagari\u0107, E., Sari\u0107, A., and Matek Sari\u0107, M. (2024). The Power of Vitamin D: Is the Future in Precision Nutrition through Personalized Supplementation Plans?. Nutrients, 16.","DOI":"10.3390\/nu16081176"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"18199","DOI":"10.1074\/jbc.M115.665794","article-title":"1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium-regulating Components","volume":"290","author":"Lee","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Carlberg, C., Raczyk, M., and Zawrotna, N. (2023). Vitamin D: A master example of nutrigenomics. Redox Biol., 62.","DOI":"10.1016\/j.redox.2023.102695"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1210\/clinem\/dgae290","article-title":"Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline","volume":"109","author":"Demay","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Grant, W.B., Wimalawansa, S.J., Pludowski, P., and Cheng, R.Z. (2025). Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines. Nutrients, 17.","DOI":"10.3390\/nu17020277"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"P\u0142udowski, P., Kos-Kud\u0142a, B., Walczak, M., Fal, A., Zozuli\u0144ska-Zi\u00f3\u0142kiewicz, D., Sieroszewski, P., Peregud-Pogorzelski, J., Lauterbach, R., Targowski, T., and Lewi\u0144ski, A. (2023). Guidelines for Preventing and Treating Vitamin D Deficiency: A 2023 Update in Poland. Nutrients, 15.","DOI":"10.3390\/nu15030695"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.it.2021.11.007","article-title":"The cholesterol pathway: Impact on immunity and cancer","volume":"43","author":"King","year":"2022","journal-title":"Trends Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41574-019-0312-5","article-title":"New aspects of vitamin D metabolism and action\u2014Addressing the skin as source and target","volume":"16","author":"Bikle","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1074\/jbc.M115.699546","article-title":"Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis","volume":"291","author":"Prabhu","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Kuan, V., Martineau, A.R., Griffiths, C.J., Hypp\u00f6nen, E., and Walton, R. (2013). DHCR7 mutations linked to higher vitamin D status allowed early human migration to Northern latitudes. BMC Evol. Biol., 13.","DOI":"10.1186\/1471-2148-13-144"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"94","DOI":"10.18433\/jpps31305","article-title":"The CYP2R1 Enzyme: Structure, Function, Enzymatic Properties and Genetic Polymorphism","volume":"4","author":"Dong","year":"2021","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Voltan, G., Cannito, M., Ferrarese, M., Ceccato, F., and Camozzi, V. (2023). Vitamin D: An Overview of Gene Regulation, Ranging from Metabolism to Genomic Effects. Genes, 14.","DOI":"10.3390\/genes14091691"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.bbagrm.2018.05.006","article-title":"The impact of the vitamin D-modulated epigenome on VDR target gene regulation","volume":"1861","author":"Nurminen","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bonr.2018.02.004","article-title":"Physiologic and pathophysiologic roles of extra renal CYP27b1: Case report and review","volume":"8","author":"Bikle","year":"2018","journal-title":"Bone Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.tibs.2004.10.005","article-title":"Enzymes involved in the activation and inactivation of vitamin D","volume":"29","author":"Prosser","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1056\/NEJMc1110226","article-title":"CYP24A1 mutations in idiopathic infantile hypercalcemia","volume":"365","author":"Streeten","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"582S","DOI":"10.1093\/ajcn\/88.2.582S","article-title":"Pharmacokinetics of vitamin D toxicity","volume":"88","author":"Jones","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S1043-2760(00)00317-9","article-title":"The multifunctional properties and characteristics of vitamin D-binding proteins","volume":"11","author":"White","year":"2000","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Carlberg, C. (2019). Nutrigenomics of Vitamin D. Nutrients, 11.","DOI":"10.3390\/nu11030676"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mce.2017.03.016","article-title":"Molecular endocrinology of vitamin D on the epigenome level","volume":"453","author":"Carlberg","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2013.09.011","article-title":"Mapping human epigenomes","volume":"155","author":"Riveram","year":"2013","journal-title":"Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrg3788","article-title":"Identifying and mitigating bias in next-generation sequencing methods for chromatin biology","volume":"15","author":"Meyer","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13690-023-01122-2","article-title":"Effect of epigenetics on vitamin D levels: A systematic review until December 2020","volume":"81","author":"Forouhari","year":"2023","journal-title":"Arch. Public Health"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jnim.2016.04.010","article-title":"Relationship between methylation status of vitamin D-related genes, vitamin D levels, and methyl-donor biochemistry","volume":"6","author":"Beckett","year":"2016","journal-title":"J. Nutr. Intermed. Metab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1101\/gad.2037511","article-title":"CpG islands and the regulation of transcription","volume":"25","author":"Deaton","year":"2011","journal-title":"Genes Dev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.steroids.2012.10.019","article-title":"Vitamin D receptor signaling mechanisms: Integrated actions of a well-defined transcription factor","volume":"78","author":"Carlberg","year":"2013","journal-title":"Steroids"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0092-8674(00)80054-9","article-title":"Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase","volume":"98","author":"Chen","year":"1999","journal-title":"Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1530\/JME-19-0246","article-title":"Genome-wide effects of chromatin on vitamin D signaling","volume":"64","author":"Hanel","year":"2020","journal-title":"J. Mol. Endocrinol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.bbagrm.2017.07.002","article-title":"Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor","volume":"1860","author":"Neme","year":"2017","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Apprato, G., Fiz, C., Fusano, I., Bergandi, L., and Silvagno, F. (2020). Natural Epigenetic Modulators of Vitamin D Receptor. Appl. Sci., 10.","DOI":"10.3390\/app10124096"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"DeLucas, M., S\u00e1nchez, J., Palou, A., and Serra, F. (2024). The Impact of Diet on miRNA Regulation and Its Implications for Health: A Systematic Review. Nutrients, 16.","DOI":"10.3390\/nu16060770"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00438-017-1301-9","article-title":"New insights into vitamin D anticancer properties: Focus on miRNA modulation","volume":"292","author":"Zeljic","year":"2017","journal-title":"Mol. Genet. Genom."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: Small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/ijc.24459","article-title":"MicroRNA regulates human vitamin D receptor","volume":"125","author":"Mohri","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jsbmb.2013.01.001","article-title":"The sum of many small changes: microRNAs are specifically and potentially globally altered by vitamin D3 metabolites","volume":"136","author":"Giangreco","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/jbmr.1882","article-title":"Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts","volume":"28","author":"Lisse","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1124\/dmd.109.027680","article-title":"MicroRNAs regulate CYP3A4 expression via direct and indirect targeting","volume":"37","author":"Pan","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3892\/ijmm.2015.2318","article-title":"1alpha,25-Dihydroxyvitamin D3 prevents the differentiation of human lung fibroblasts via microRNA-27b targeting the vitamin D receptor","volume":"36","author":"Li","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1124\/mol.109.056986","article-title":"Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b","volume":"76","author":"Komagata","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"41297","DOI":"10.1074\/jbc.M112.407189","article-title":"1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498","volume":"287","author":"Kasiappan","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1074\/jbc.M112.395947","article-title":"Identification of microRNA-98 as a therapeutic target inhibiting prostate cancer growth and a biomarker induced by vitamin D","volume":"288","author":"Ting","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_86","first-page":"264","article-title":"Vitamin D receptor genotype modulates the correlation between vitamin D and circulating levels of let-7a\/b and vitamin D intake in an elderly cohort","volume":"7","author":"Beckett","year":"2015","journal-title":"J. Nutrigenet Nutrigenom."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jsbmb.2010.03.073","article-title":"A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations","volume":"121","author":"McGrath","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1002\/jcp.26216","article-title":"Genetic and epigenetic factors influencing vitamin D status","volume":"233","author":"Bahrami","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Pineda-Lancheros, L.E., G\u00e1lvez-Navas, J.M., Rojo-Tolosa, S., Membrive-Jim\u00e9nez, C., Valverde-Merino, M.I., Mart\u00ednez-Mart\u00ednez, F., S\u00e1nchez-Mart\u00edn, A., Ram\u00edrez-Tortosa, M., P\u00e9rez-Ram\u00edrez, C., and Jim\u00e9nez-Morales, A. (2023). Polymorphisms in VDR, CYP27B1, CYP2R1, GC and CYP24A1 Genes as Biomarkers of Survival in Non-Small Cell Lung Cancer: A Systematic Review. Nutrients, 15.","DOI":"10.3390\/nu15061525"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1475-2891-12-96","article-title":"Relationship between Vitamin D Receptor gene polymorphisms and the components of metabolic syndrome","volume":"12","author":"Schuch","year":"2013","journal-title":"Nutr. J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00223-012-9660-z","article-title":"Genetic Regulation of Vitamin D Levels","volume":"92","author":"Dastani","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Usategui-Mart\u00edn, R., De Luis-Rom\u00e1n, D.A., Fern\u00e1ndez-G\u00f3mez, J.M., Ruiz-Mambrilla, M., and P\u00e9rez-Castrill\u00f3n, J.L. (2022). Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis. Nutrients, 14.","DOI":"10.3390\/nu14020360"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00251-018-1063-5","article-title":"Cdx-2 polymorphism in the vitamin D receptor gene (VDR) marks VDR expression in monocyte\/macrophages through VDR promoter methylation","volume":"70","author":"Meyer","year":"2018","journal-title":"Immunogenetics"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00439-011-1099-1","article-title":"Associations between common variants in GC and DHCR7\/NADSYN1 and vitamin D concentration in Chinese Hans","volume":"131","author":"Lu","year":"2012","journal-title":"Hum. Genet."},{"key":"ref_95","first-page":"w13636","article-title":"The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children","volume":"142","author":"Zhang","year":"2012","journal-title":"Swiss Med. Wkly."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.gene.2018.08.056","article-title":"Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic review and meta-analysis","volume":"678","author":"Duan","year":"2018","journal-title":"Gene"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/dmrr.719","article-title":"CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans","volume":"23","author":"Jansen","year":"2007","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"13977","DOI":"10.1002\/jcp.28083","article-title":"A variant in CYP2R1 predicts circulating vitamin D levels after supplementation with high-dose of vitamin D in healthy adolescent girls","volume":"234","author":"Khayyatzadeh","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Nissen, J., Rasmussen, L.B., Ravn-Haren, G., Andersen, E.W., Hansen, B., Andersen, R., Mejborn, H., Madsen, K.H., and Vogel, U. (2014). Common variants in CYP2R1 and GC genes predict vitamin D concentrations in healthy Danish children and adults. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0089907"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/hmg\/ddq155","article-title":"Genome-wide association study of circulating vitamin D levels","volume":"19","author":"Ahn","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Signorello, L.B., Shi, J., Cai, Q., Zheng, W., Williams, S.M., Long, J., Cohen, S.S., Li, G., Hollis, B.W., and Smith, J.R. (2011). Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028623"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"8289741","DOI":"10.1155\/2019\/8289741","article-title":"The Association between Polymorphisms of Vitamin D Metabolic-Related Genes and Vitamin D3 Supplementation in Type 2 Diabetic Patients","volume":"2019","author":"Hu","year":"2019","journal-title":"J. Diabetes Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"109607","DOI":"10.1016\/j.steroids.2025.109607","article-title":"Genetic insights into vitamin D deficiency: A case-control study of GC and CYP24A1 gene polymorphisms","volume":"218","author":"Usama","year":"2025","journal-title":"Steroids"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"E423","DOI":"10.1210\/jc.2011-1935","article-title":"Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: Effects of ketoconazole therapy","volume":"97","author":"Tebben","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/BF00194311","article-title":"Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): Allelic differences of the common genetic GC types","volume":"89","author":"Braun","year":"1992","journal-title":"Hum. Genet."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/clinchem\/47.4.753","article-title":"Mean serum concentration of vitamin D-binding protein (Gc globulin) is related to the Gc phenotype in women","volume":"47","author":"Lauridsen","year":"2001","journal-title":"Clin. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.clinbiochem.2009.03.008","article-title":"Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation","volume":"42","author":"Fu","year":"2009","journal-title":"Clin. Biochem."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Rozmus, D., P\u0142omi\u0144ski, J., Augustyn, K., and Cie\u015bli\u0144ska, A. (2022). rs7041 and rs4588 Polymorphisms in Vitamin D Binding Protein Gene (VDBP) and the Risk of Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020933"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Hypp\u00f6nen, E., Vimaleswaran, K.S., and Zhou, A. (2022). Genetic Determinants of 25-Hydroxyvitamin D Concentrations and Their Relevance to Public Health. Nutrients, 14.","DOI":"10.3390\/nu14204408"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jsbmb.2013.10.004","article-title":"DNA methylation levels of CYP2R1 and CYP24A1 predict vitamin D response variation","volume":"144","author":"Zhou","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jsbmb.2016.12.011","article-title":"The concept of the personal vitamin D response index","volume":"175","author":"Carlberg","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jsbmb.2014.11.012","article-title":"Dissecting high from low responders in a vitamin D3 intervention study","volume":"148","author":"Saksa","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Gospodarska, E., Ghosh Dastidar, R., and Carlberg, C. (2023). Intervention Approaches in Studying the Response to Vitamin D3 Supplementation. Nutrients, 29.","DOI":"10.3390\/nu15153382"}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/15\/7\/436\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:01:34Z","timestamp":1760032894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/15\/7\/436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":113,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["metabo15070436"],"URL":"https:\/\/doi.org\/10.3390\/metabo15070436","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}