{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:59:28Z","timestamp":1784228368095,"version":"3.55.0"},"reference-count":41,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Background: Type 2 diabetes mellitus (T2DM) is a major contributor to cardiovascular disease worldwide, with insulin resistance (IR) being a central pathophysiological mechanism. The triglyceride\u2013glucose (TyG) index, derived from routine fasting measures, has emerged as a simple yet reliable proxy for IR and is increasingly recognised for its prognostic value in metabolic disorders. Despite growing interest, longitudinal evidence on TyG and incident T2DM, especially within European cohorts, remains limited and inconsistent. Therefore, we aimed to estimate the predictive role of TyG on the development of T2DM in an 8-year follow-up observation of a sample of adult men. Methods: We analysed data from 789 adult men without baseline T2DM, enrolled in the Olivetti Heart Study. Receiver operating characteristic curve analysis was used to determine the optimal TyG threshold for predicting new-onset T2DM. Results: Baseline TyG exhibited a strong, linear association with the subsequent development of T2DM. A TyG value above 4.88 was associated with an approximately twofold increase in risk, both before and after adjustment for confounding factors. Conclusions: The principal findings of this study indicate a significant predictive value of the TyG index in the development of new-onset T2DM. These observations suggest that the TyG index may serve as a low-cost, simple, and non-invasive tool for early cardio-metabolic risk assessment.<\/jats:p>","DOI":"10.3390\/metabo15080537","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T09:56:42Z","timestamp":1754647002000},"page":"537","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Triglyceride\u2013Glucose Index and New-Onset Type 2 Diabetes Mellitus in Middle-Aged Men"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1782-0211","authenticated-orcid":false,"given":"Lanfranco","family":"D\u2019Elia","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery, \u201cFederico II\u201d University of Naples Medical School, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0331-0392","authenticated-orcid":false,"given":"Domenico","family":"Rendina","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, \u201cFederico II\u201d University of Naples Medical School, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Iacone","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, \u201cFederico II\u201d University of Naples Medical School, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Strazzullo","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, \u201cFederico II\u201d University of Naples Medical School, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferruccio","family":"Galletti","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, \u201cFederico II\u201d University of Naples Medical School, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"ref_1","unstructured":"International Diabetes Federation (2019). IDF Diabetes Atlas, International Diabetes Federation. [9th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","article-title":"2023 ESH Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension","volume":"41","author":"Mancia","year":"2023","journal-title":"J. Hypertens."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s40292-017-0240-1","article-title":"Excess body weight, insulin resistance and isolated systolic hypertension: Potential pathophysiological links","volume":"25","author":"Strazzullo","year":"2018","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1573399810666140214093600","article-title":"Assessment of pancreatic \u03b2 cell function: Review of methods and clinical applications","volume":"10","author":"Cersosimo","year":"2014","journal-title":"Curr. Diabetes Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/met.2008.0034","article-title":"The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects","volume":"6","year":"2008","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1210\/jc.2010-0288","article-title":"The product of triglycerides and glucose, a simple measure of insulin sensitivity: Comparison with the euglycemic\u2013hyperinsulinemic clamp","volume":"95","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_7","first-page":"4678526","article-title":"Diagnostic accuracy of the triglyceride and glucose index for insulin resistance: A systematic review","volume":"2020","author":"Solis","year":"2020","journal-title":"Int. J. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"103834","DOI":"10.1016\/j.numecd.2024.103834","article-title":"Is the triglyceride\u2013glucose index ready for cardiovascular risk assessment?","volume":"35","year":"2025","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12933-022-01546-0","article-title":"Relationship between the triglyceride\u2013glucose index and risk of cardiovascular diseases and mortality in the general population: A systematic review and meta-analysis","volume":"21","author":"Liu","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Muhammad, I.F., Bao, X., Nilsson, P.M., and Zaigham, S. (2023). Triglyceride\u2013glucose (TyG) index is a predictor of arterial stiffness, incidence of diabetes, cardiovascular disease, and all-cause and cardiovascular mortality: A longitudinal two-cohort analysis. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.1035105"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/S2666-7568(22)00247-1","article-title":"Association of the triglyceride\u2013glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): A prospective cohort study","volume":"4","author":"Abat","year":"2023","journal-title":"Lancet Healthy Longev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e470","DOI":"10.1210\/clinem\/dgae170","article-title":"Triglyceride\u2013glucose index and mortality in a large regional based Italian database (Urrah Project)","volume":"110","author":"Masulli","year":"2025","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_13","first-page":"101135","article-title":"Association of the triglyceride\u2013glucose index with all-cause and cause specific mortality: A population-based cohort study of 3.5 million adults in China","volume":"49","author":"He","year":"2024","journal-title":"Lancet Reg. Health West. Pac."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2272581","DOI":"10.1080\/10641963.2023.2272581","article-title":"TyG index is a predictor of all-cause mortality during long-term follow-up in middle-aged and elderly individuals with hypertension","volume":"45","author":"Pang","year":"2023","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Li, X., Sun, M., Yang, Y., Yao, N., Yan, S., Wang, L., Hu, W., Guo, R., Wang, Y., and Li, B. (2022). Predictive effect of triglyceride\u2013glucose-related parameters, obesity indices, and lipid ratios for diabetes in a Chinese population: A prospective cohort study. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.862919"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12944-020-01403-7","article-title":"Association between triglyceride\u2013glucose index and risk of incident diabetes: A secondary analysis based on a Chinese cohort study","volume":"19","author":"Li","year":"2020","journal-title":"Lipids Health Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Shan, Y., Liu, Q., and Gao, T. (2025). Triglyceride\u2013glucose index in predicting the risk of new onset diabetes in the general population aged \u226545 years: A national prospective cohort study. BMC Endocr. Disord., 25.","DOI":"10.1186\/s12902-025-01848-w"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s12967-023-04159-7","article-title":"Assessing temporal differences in the predictive power of baseline TyG related parameters for future diabetes: An analysis using time dependent receiver operating characteristics","volume":"21","author":"Kuang","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lee, J.W., Lim, N.K., and Park, H.Y. (2018). The product of fasting plasma glucose and triglycerides improves risk prediction of type 2 diabetes in middle aged Koreans. BMC Endocr. Disord., 18.","DOI":"10.1186\/s12902-018-0259-x"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Chen, C.L., Liu, L., Lo, K., Huang, J.Y., Yu, Y.L., Huang, Y.Q., and Feng, Y.Q. (2020). Association between triglyceride\u2013glucose index and risk of new onset diabetes among Chinese adults: Findings from the China Health and Retirement Longitudinal Study. Front. Cardiovasc. Med., 7.","DOI":"10.3389\/fcvm.2020.610322"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.pcd.2020.09.001","article-title":"Triglyceride\u2013glucose index predicts type 2 diabetes mellitus risk: A systematic review and meta-analysis of cohort studies","volume":"14","author":"Caldas","year":"2020","journal-title":"Prim. Care Diabetes"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s12020-021-02780-4","article-title":"The association between triglyceride\u2013glucose index and the incidence of type 2 diabetes mellitus: A systematic review and dose response meta-analysis","volume":"74","author":"Pranata","year":"2021","journal-title":"Endocrine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s00125-019-4921-2","article-title":"Novel metabolic indices and incident type 2 diabetes among women and men: The Rotterdam Study","volume":"62","author":"Brahimaj","year":"2019","journal-title":"Diabetologia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ypmed.2016.01.022","article-title":"Triglyceride\u2013glucose index (TyG index) in comparison with fasting plasma glucose improves diabetes prediction in patients with normal fasting glucose: The Vascular Metabolic CUN cohort","volume":"86","author":"Martinez","year":"2016","journal-title":"Prev. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/eurpub\/ckt041","article-title":"Not smoking is associated with lower risk of hypertension: Results of the Olivetti Heart Study","volume":"24","author":"Rossi","year":"2014","journal-title":"Eur. J. Public. Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.numecd.2016.03.009","article-title":"The Olivetti Heart Study: Predictive value of a new adiposity index on risk of hypertension, blood pressure, and subclinical organ damage","volume":"26","author":"Manfredi","year":"2016","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_27","unstructured":"EQUATOR Network STROBE Guidelines. Available online: https:\/\/www.equator-network.org\/reporting-guidelines\/strobe\/."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee (2024). 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes\u20142024. Diabetes Care, 47, S20\u2013S42.","DOI":"10.2337\/dc24-S002"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1053\/j.ajkd.2013.12.006","article-title":"GFR estimation: From physiology to public health","volume":"63","author":"Levey","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"ref_30","unstructured":"World Health Organization Obesity and Overweight. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation, 106, 3143\u20133421.","DOI":"10.1161\/circ.106.25.3143"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Harrell, F.E. (2001). Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis, Springer.","DOI":"10.1007\/978-1-4757-3462-1"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.numecd.2024.07.005","article-title":"Predictive role of triglyceride\u2013glucose index and HOMA index on development of arterial stiffening in non diabetic men","volume":"34","author":"Masulli","year":"2024","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_34","first-page":"301","article-title":"Triglyceride\u2013glucose index, HOMA index and metabolic syndrome in a sample of adult men","volume":"115","author":"Masulli","year":"2024","journal-title":"Minerva Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.beem.2007.04.007","article-title":"Sexual dimorphism of body composition","volume":"21","author":"Wells","year":"2007","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1210\/er.2012-1055","article-title":"The role of estrogens in control of energy balance and glucose homeostasis","volume":"34","author":"Clegg","year":"2013","journal-title":"Endocr. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s12265-009-9101-1","article-title":"Sexual dimorphism in body fat distribution and risk for cardiovascular diseases","volume":"2","author":"Nedungadi","year":"2009","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"D\u2019Elia, L. (2024). Potassium intake and human health. Nutrients, 16.","DOI":"10.3390\/nu16060833"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1001\/archinternmed.2010.362","article-title":"Serum and dietary potassium and risk of incident type 2 diabetes mellitus: The Atherosclerosis Risk in Communities (ARIC) Study","volume":"170","author":"Chatterjee","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.jdiacomp.2016.03.017","article-title":"Effects of potassium citrate or potassium chloride in patients with combined glucose intolerance: A placebo controlled pilot study","volume":"30","author":"Conen","year":"2016","journal-title":"J. Diabetes Complicat."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.3945\/ajcn.117.161570","article-title":"Effects of potassium supplementation on glucose metabolism in African Americans with prediabetes: A pilot trial","volume":"106","author":"Chatterjee","year":"2017","journal-title":"Am. J. Clin. Nutr."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/15\/8\/537\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:26:05Z","timestamp":1760034365000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/15\/8\/537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":41,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["metabo15080537"],"URL":"https:\/\/doi.org\/10.3390\/metabo15080537","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]}}}