{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:38:13Z","timestamp":1760060293602,"version":"build-2065373602"},"reference-count":56,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DFG"},{"name":"the University of Brasilia"},{"name":"FAP DF, Brazil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Objectives: Multiple myeloma and acute myeloid leukemia are severe forms of blood cancer, which lack effective therapies for treatment. In our search for new chemical lead structures from nature, we were investigating the Brazilian medicinal plant arnica-do-cerrado (Lychnophora ericoides). Methods: Repeated chromatography led to the isolation of four flavonoids and three sesquiterpenoids, which were evaluated for their cytostatic and cytotoxic properties against HL-60, MOLM-13, AMO-1, and KMS-12 PE cancer cells as well as the non-malignant HS-5 cell line. Results: Whereas the isolated flavonoids displayed only moderate activity, the three sesquiterpene lactones goyazensolide, centratherin, and lychnopholide exhibited pronounced effects against all four tested cell lines. Goyazensolide was the most effective compound, inhibiting proliferation and metabolic activity with IC50 values between 1.0 and 1.6 \u00b5M, as well as 1.0 to 2.0 \u00b5M, respectively. Centratherin and lychnopholide were somewhat less active but showed higher selectivity towards malignant cell lines, which was most pronounced for MOLM-13 cells. Conclusion: The results of this study revealed interesting natural products that will be further evaluated for their potential as new lead compounds for the treatment of acute myeloid leukemia and multiple myeloma.<\/jats:p>","DOI":"10.3390\/metabo15080542","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T09:59:13Z","timestamp":1754906353000},"page":"542","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Flavonoids and Sesquiterpene Lactones from Lychnophora ericoides (Arnica-Do-Cerrado) and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1256-4124","authenticated-orcid":false,"given":"Calisto","family":"Moreno Cardenas","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biology, Kiel University, Gutenbergstra\u00dfe 76, 24118 Kiel, Germany"},{"name":"Department of Biotechnology, Hamburg University of Applied Sciences, Ulmenliet 20, 21033 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren Ove","family":"Kratzert","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology, Kiel University, Gutenbergstra\u00dfe 76, 24118 Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie","family":"Hanifle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V (Hematology and Oncology), Medical University of Innsbruck, Anichstra\u00dfe 35, 6020 Innsbruck, Austria"},{"name":"Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elida Cleyse","family":"Gomes da Mata Kanzaki","sequence":"additional","affiliation":[{"name":"Laboratory of Bioprospection, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1143-4025","authenticated-orcid":false,"given":"Isamu","family":"Kanzaki","sequence":"additional","affiliation":[{"name":"Laboratory of Bioprospection, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1624-2664","authenticated-orcid":false,"given":"Brigitte","family":"Kircher","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V (Hematology and Oncology), Medical University of Innsbruck, Anichstra\u00dfe 35, 6020 Innsbruck, Austria"},{"name":"Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3038-8523","authenticated-orcid":false,"given":"Serhat Sezai","family":"\u00c7i\u00e7ek","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology, Kiel University, Gutenbergstra\u00dfe 76, 24118 Kiel, Germany"},{"name":"Department of Biotechnology, Hamburg University of Applied Sciences, Ulmenliet 20, 21033 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1200\/JCO.2015.61.2267","article-title":"Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group","volume":"33","author":"Palumbo","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41408-020-00348-5","article-title":"Cytogenetic abnormalities in multiple myeloma: Association with disease characteristics and treatment response","volume":"10","author":"Abdallah","year":"2020","journal-title":"Blood Cancer J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1182\/blood-2016-08-733196","article-title":"Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel","volume":"129","author":"Estey","year":"2017","journal-title":"Blood"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural Products as Sources of New Drugs over the Nearly Four Decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Willer, J., J\u00f6hrer, K., Greil, R., Zidorn, C., and \u00c7i\u00e7ek, S.S. (2019). Cytotoxic Properties of Damiana (Turnera diffusa) Extracts and Constituents and A Validated Quantitative UHPLC-DAD Assay. Molecules, 24.","DOI":"10.3390\/molecules24050855"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"10489","DOI":"10.1039\/D0RA10973H","article-title":"Cytotoxic constituents and a new hydroxycinnamic acid derivative from Leontodon saxatilis (Asteraceae, Cichorieae)","volume":"11","author":"Willer","year":"2021","journal-title":"RSC Adv."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"J\u00f6hrer, K., Galarza P\u00e9rez, M., Kircher, B., and \u00c7i\u00e7ek, S.S. (2022). Flavones, Flavonols, Lignans, and Caffeic Acid Derivatives from Dracocephalum moldavica and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232214219"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"J\u00f6hrer, K., Stuppner, H., Greil, R., and \u00c7i\u00e7ek, S.S. (2020). Structure-Guided Identification of Black Cohosh (Actaea racemosa) Triterpenoids with In Vitro Activity against Multiple Myeloma. Molecules, 25.","DOI":"10.3390\/molecules25040766"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ayvazyan, A., Deutsch, L., Zidorn, C., Kircher, B., and \u00c7i\u00e7ek, S.S. (2023). Cytotoxic diterpenoids from Salvia glutinosa and comparison with the tanshinone profile of danshen (Salvia miltiorrhiza). Front. Plant Sci., 14.","DOI":"10.3389\/fpls.2023.1269710"},{"key":"ref_10","unstructured":"Compositae Working Group (CWG) (2025, March 25). Global Compositae Database. Lychnophora ericoides Mart. Available online: https:\/\/www.compositae.org\/gcd\/aphia.php?p=taxdetails&id=1089066."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/00087114.2002.10797889","article-title":"Chromosome numbers in the genus Lychnophora Mart. (Lychnophorinae, Vernonieae, Asteraceae)","volume":"55","author":"Mansanares","year":"2002","journal-title":"Caryologia"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1248\/cpb.52.1433","article-title":"Production of an antiproliferative furanoheliangolide by Lychnophora ericoides cell culture","volume":"52","author":"Amarante","year":"2004","journal-title":"Chem. Pharm. Bull."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bjp.2014.09.005","article-title":"Assessment of acute toxicity of the ethanolic extract of Lychnophora pinaster (Brazilian arnica)","volume":"24","author":"Ferreira","year":"2014","journal-title":"Rev. Bras. Farm."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0031-9422(00)82422-X","article-title":"Germacranolides from Lychnophora species","volume":"21","author":"Bohlmann","year":"1982","journal-title":"Phytochemistry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF02919190","article-title":"Sesquiterpene lactones as taxonomic characters in the asteraceae","volume":"48","author":"Seaman","year":"1982","journal-title":"Bot. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jep.2004.09.043","article-title":"Analgesic activity of di-caffeoylquinic acids from roots of Lychnophora ericoides (Arnica da serra)","volume":"96","author":"Albarella","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0031-9422(00)00388-5","article-title":"Analgesic activity of the lignans from Lychnophora ericoides","volume":"55","author":"Borsato","year":"2000","journal-title":"Phytochemistry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"113738","DOI":"10.1016\/j.jep.2020.113738","article-title":"Sesquiterpene lactones from Lychnophora species: Antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout","volume":"269","author":"Bernardes","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/(SICI)1099-1573(199611)10:7<636::AID-PTR921>3.0.CO;2-6","article-title":"In vitro Screening of Asteraceae Plant Species Against Trypanosoma cruzi","volume":"10","author":"Chiari","year":"1996","journal-title":"Phytother. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1078\/094471103322331430","article-title":"Trypanocidal activity of Lychnophora staavioides Mart. (Vernonieae, Asteraceae)","volume":"10","author":"Takeara","year":"2003","journal-title":"Phytomedicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1590\/S0102-695X2005000400006","article-title":"Biological activity of the aqueous extract of Lychnophora pinaster Mart","volume":"15","author":"Silveira","year":"2005","journal-title":"Rev. Bras. Farm."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"J\u00f6hrer, K., and \u04aai\u04abek, S.S. (2021). Multiple Myeloma Inhibitory Activity of Plant Natural Products. Cancers, 13.","DOI":"10.3390\/cancers13112678"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4176","DOI":"10.1021\/jf060234n","article-title":"Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel","volume":"54","author":"Li","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1248\/cpb.50.788","article-title":"Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity","volume":"50","author":"Matsuda","year":"2002","journal-title":"Chem. Pharm. Bull."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.1039\/D2CC01538B","article-title":"Visible light-induced deoxygenation\/cyclization of salicylic acid derivatives and aryl acetylene for the synthesis of flavonoids","volume":"58","author":"Fan","year":"2022","journal-title":"Chem. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.1080\/14786419.2021.2016747","article-title":"Myobontioids A-D and antifungal metabolites from the leaves of Myoporum bontioides A. Gray","volume":"36","author":"Minh","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/mrc.819","article-title":"Reassignment of NMR spectra and conformational study of the sesquiterpene lactone goyazensolide","volume":"39","author":"Perry","year":"2001","journal-title":"Magn. Reson. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Machado, F.P., Wermelinger, G.F., Canuto, A.d.S.C.L., Da Fonseca, A.C.C., Folly, D., Arruda, A.T.S., Rocha, L., and Robbs, B.K. (2024). Antitumoral effect thought ROS production of the sesquiterpene lactone centratherin isolated from Eremanthus crotonoides, an endemic plant from Brazil. Nat. Prod. Res., 1\u20138.","DOI":"10.1080\/14786419.2024.2427812"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1016\/j.tet.2012.01.061","article-title":"Cytotoxic and NF-\u03baB inhibitory sesquiterpene lactones from Piptocoma rufescens","volume":"68","author":"Ren","year":"2012","journal-title":"Tetrahedron"},{"key":"ref_30","first-page":"8273789","article-title":"Antibacterial and Antioxidant Activities of Triterpenoids Isolated from Endemic Euphorbia arbuscula Stem Latex","volume":"2024","author":"Masaoud","year":"2024","journal-title":"Adv. Pharmacol. Pharm. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s00277-019-03797-6","article-title":"Pixantrone demonstrates significant in vitro activity against multiple myeloma and plasma cell leukemia","volume":"98","author":"Willenbacher","year":"2019","journal-title":"Ann. Hematol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/156800910791054239","article-title":"Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function","volume":"10","author":"Gandhi","year":"2010","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12935-025-03741-x","article-title":"Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: A double-edged sword","volume":"25","author":"Kamrani","year":"2025","journal-title":"Cancer Cell Int."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ciciarello, M., Corradi, G., Forte, D., Cavo, M., and Curti, A. (2021). Emerging Bone Marrow Microenvironment-Driven Mechanisms of Drug Resistance in Acute Myeloid Leukemia: Tangle or Chance?. Cancers, 13.","DOI":"10.3390\/cancers13215319"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e415","DOI":"10.3324\/haematol.2018.207704","article-title":"A metabolic switch in proteasome inhibitor-resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis","volume":"104","author":"Besse","year":"2019","journal-title":"Haematologica"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Caillot, M., Zylbersztejn, F., Maitre, E., Bourgeais, J., H\u00e9rault, O., and Sola, B. (2020). ROS Overproduction Sensitises Myeloma Cells to Bortezomib-Induced Apoptosis and Alleviates Tumour Microenvironment-Mediated Cell Resistance. Cells, 9.","DOI":"10.3390\/cells9112357"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Abramson, H.N. (2023). Immunotherapy of Multiple Myeloma: Current Status as Prologue to the Future. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202309.1180.v1"},{"key":"ref_38","first-page":"347","article-title":"Evaluation of chemosensitivity of human bone marrow stromal cells--differences between common chemotherapeutic drugs","volume":"26","author":"Schmidmaier","year":"2006","journal-title":"Anticancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Descher, H., Strich, S.L., Hermann, M., Enoh, P., Kircher, B., and Gust, R. (2023). Investigations on the Influence of the Axial Ligand in Salophene iron(III) Complexes on Biological Activity and Redox Behavior. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032173"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10555-010-9235-2","article-title":"Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals","volume":"29","author":"Gupta","year":"2010","journal-title":"Cancer Metastasis Rev."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Steiner, N., J\u00f6hrer, K., Plewan, S., Brunner-V\u00e9ber, A., G\u00f6bel, G., Nachbaur, D., Wolf, D., Gunsilius, E., and Untergasser, G. (2020). The FMS like Tyrosine Kinase 3 (FLT3) Is Overexpressed in a Subgroup of Multiple Myeloma Patients with Inferior Prognosis. Cancers, 12.","DOI":"10.3390\/cancers12092341"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Guo, L., Li, Y., Mao, X., Tao, R., Tao, B., and Zhou, Z. (2022). Antifungal Activity of Polymethoxylated Flavonoids (PMFs)-Loaded Citral Nanoemulsion against Penicillium italicum by Causing Cell Membrane Damage. J. Fungi, 8.","DOI":"10.3390\/jof8040388"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"836","DOI":"10.2174\/187152012802650075","article-title":"Flavonoids in cancer prevention","volume":"12","author":"Park","year":"2012","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Bao, Y., and Fenwick, R. (2004). Polymethylated Flavonoids: Cancer Preventive and Therapeutic Potentials Derived from Anti-Inflammatory and Drug Metabolism-Modifying Properties. Phytochemicals in Health and Disease, CRC Press. [1st ed.].","DOI":"10.1201\/9780203021408-17"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1080\/07352689.2016.1145956","article-title":"Sesquiterpene Lactones: More Than Protective Plant Compounds with High Toxicity","volume":"35","year":"2016","journal-title":"Crit. Rev. Plant Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.drudis.2010.06.002","article-title":"What made sesquiterpene lactones reach cancer clinical trials?","volume":"15","author":"Ghantous","year":"2010","journal-title":"Drug Discov. Today"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.biopha.2018.06.131","article-title":"Application of sesquiterpene lactone: A new promising way for cancer therapy based on anticancer activity","volume":"106","author":"Babaei","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Moujir, L., Callies, O., Sousa, P.M.C., Sharopov, F., and Seca, A.M.L. (2020). Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases. Appl. Sci., 10.","DOI":"10.3390\/app10093001"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1021\/acs.jnatprod.9b00018","article-title":"Potential Anticancer Agents Characterized from Selected Tropical Plants","volume":"82","author":"Ren","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1080\/17460441.2023.2147920","article-title":"Lessons learned from the discovery and development of the sesquiterpene lactones in cancer therapy and prevention","volume":"17","author":"Cheikh","year":"2022","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.2174\/0929867323666160510123255","article-title":"Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones","volume":"23","author":"Ren","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3923\/ijcr.2013.36.53","article-title":"Goyazensolide Induces Apoptosis in Cancer Cells in vitro and in vivo","volume":"9","author":"Shen","year":"2013","journal-title":"Int. J. Cancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1021\/acs.jnatprod.7b01079","article-title":"Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens","volume":"81","author":"Ren","year":"2018","journal-title":"J. Nat. Prod."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ejmech.2013.02.018","article-title":"Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: Structure-activity relationships","volume":"63","author":"Schomburg","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1055\/s-2006-951711","article-title":"Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea","volume":"72","author":"Vongvanich","year":"2006","journal-title":"Planta Medica"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1590\/S0102-695X2012005000131","article-title":"Antiproliferative activity of Eremanthus crotonoides extracts and centratherin demonstrated in brain tumor cell lines","volume":"22","author":"Lobo","year":"2012","journal-title":"Rev. Bras. Farm."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/15\/8\/542\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:27:26Z","timestamp":1760034446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/15\/8\/542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,9]]},"references-count":56,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["metabo15080542"],"URL":"https:\/\/doi.org\/10.3390\/metabo15080542","relation":{},"ISSN":["2218-1989"],"issn-type":[{"type":"electronic","value":"2218-1989"}],"subject":[],"published":{"date-parts":[[2025,8,9]]}}}