{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:44:38Z","timestamp":1787636678268,"version":"build-2736575974"},"reference-count":71,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Background: This study investigated the hypolipidemic and hepatoprotective effects of refined soybean oil supplemented with an Ocimum basilicum L. extract, characterized by HPLC and found to be rich in caftaric, caffeic, chicoric, and rosmarinic acids. Methods: After a 12-week model of diet-induced hyperlipidemia, we examined the plasma levels of TC, TG, Glucose, HDL-C, and LDL-C and the LDL-C\/HDL-C ratio using enzymatic kits. The Plasma Hepatic and Biliary Marker Analysis was analysed following standardized hospital protocols with quality-controlled instrumentation. Results: The supplementation with Basil-Enriched Oil (BEO) resulted in a notable redistribution of lipids, significantly reducing the plasma total cholesterol (\u221275%), triglycerides (\u221296%), and glucose (\u221222%), while enhancing their hepatic sequestration. This was accompanied by a marked improvement in the LDL-C\/HDL-C ratio and a reduction in hepatic oxidative stress (measured by MDA). Importantly, BEO preserved liver structure and prevented steatosis, despite inducing an increase in adaptive hepatomegaly. Conclusions: The results reveal a dual mechanism whereby the antioxidant properties of BEO collaborate with reprogrammed lipid metabolism, promoting safe hepatic storage rather than harmful circulating levels. These findings strongly advocate for the extract\u2019s potential as a nutraceutical for addressing hyperlipidemia and related metabolic disorders by targeting both oxidative stress and lipid imbalance. Further research is required to confirm these effects in clinical settings and to confirm its long-term efficacy.<\/jats:p>","DOI":"10.3390\/metabo16020115","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T15:24:19Z","timestamp":1770305059000},"page":"115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lipid-Lowering and Hepatoprotective Effects of Basil-Enriched Soybean Oil (BEO) in High-Fat-Diet-Fed Mice"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1134-5561","authenticated-orcid":false,"given":"Amani","family":"Tayebi","sequence":"first","affiliation":[{"name":"Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Faculty of Sciences, University Mohamed I, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5055-3692","authenticated-orcid":false,"given":"Mohammadine","family":"Moumou","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Faculty of Sciences, University Mohamed I, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhay","family":"Addous","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Faculty of Sciences, University Mohamed I, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9407-7576","authenticated-orcid":false,"given":"Oussama","family":"Khibech","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Chemistry and Environment (LCAE), Faculty of Sciences, University Mohamed I, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niama","family":"Hammani","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Faculty of Sciences, University Mohamed I, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssra","family":"Salhi","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Faculty of Sciences, University Mohamed I, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-0912","authenticated-orcid":false,"given":"Dragan","family":"Milenkovic","sequence":"additional","affiliation":[{"name":"Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC 28081, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8707-6854","authenticated-orcid":false,"given":"Ahmed","family":"Karim","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Faculty of Sciences, University Mohamed I, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Choukri","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory, Central Laboratory Service, University Hospital Center, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souliman","family":"Amrani","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Faculty of Sciences, University Mohamed I, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7492-0692","authenticated-orcid":false,"given":"Hicham","family":"Harnafi","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Faculty of Sciences, University Mohamed I, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2025, November 16). Cardiovascular Diseases (CVDs). WHO Fact Sheets. Available online: https:\/\/www.who.int\/westernpacific\/health-topics\/cardiovascular-diseases."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1016\/j.jacc.2023.11.007","article-title":"Global Burden of Cardiovascular Diseases and Risks Collaborators Global Burden of Cardiovascular Diseases and Risks, 1990\u20132022","volume":"82","author":"Mensah","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/eurjpc\/zwaf104","article-title":"Remnant Cholesterol, Plasma Triglycerides, and Risk of Cardiovascular Disease Events in Young Adults: A Prospective Cohort Study","volume":"32","author":"Aaseth","year":"2025","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Xu, D., Xie, L., Cheng, C., Xue, F., and Sun, C. (2024). Triglyceride-Rich Lipoproteins and Cardiovascular Diseases. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1409653"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/CIRCRESAHA.115.306249","article-title":"Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease","volume":"118","author":"Nordestgaard","year":"2016","journal-title":"Circ. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1161\/ATVBAHA.116.308305","article-title":"Remnant Cholesterol and Triglyceride-Rich Lipoproteins in Atherosclerosis Progression and Cardiovascular Disease","volume":"36","author":"Varbo","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1161\/CIR.0b013e3182160726","article-title":"Triglycerides and Cardiovascular Disease: A Scientific Statement from the American Heart Association","volume":"123","author":"Miller","year":"2011","journal-title":"Circulation"},{"key":"ref_8","first-page":"1","article-title":"Triglyceride Metabolism in the Liver","volume":"8","author":"Cohen","year":"2018","journal-title":"Compr. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Allameh, A., Niayesh-Mehr, R., Aliarab, A., Sebastiani, G., and Pantopoulos, K. (2023). Oxidative Stress in Liver Pathophysiology and Disease. Antioxidants, 12.","DOI":"10.3390\/antiox12091653"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11883-021-00918-3","article-title":"Lipid Lowering Drugs: Present Status and Future Developments","volume":"23","author":"Ruscica","year":"2021","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_11","first-page":"68","article-title":"Hepatoprotective Effect of Ocimum basilicum Aqueous Extract against Doxorubicin-Induced Hepatic Damage in Albino Rats","volume":"21","author":"Islam","year":"2024","journal-title":"Asian J. Trop. Biotechnol."},{"key":"ref_12","first-page":"226","article-title":"Therapeutic Role of Methanolic Extract of Ocimum basilicum L. Seeds and its Isolated Compound as Potent Antidiabetic and Antihyperlipidemic Agents","volume":"10","author":"Parikh","year":"2020","journal-title":"Nat. Prod. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/jfbc.12121","article-title":"Rosmarinic Acid Levels, Phenolic Contents, Antioxidant and Antimicrobial Activities of the Extracts from Salvia verbenaca L. Obtained with Different Solvents and Procedures","volume":"39","year":"2015","journal-title":"J. Food Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.2174\/09298673113209990141","article-title":"Antioxidant Properties of Hydroxycinnamic Acids: A Review of Structure-Activity Relationships","volume":"20","author":"Garrido","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.bionut.2013.03.005","article-title":"Phenolic Acid-Rich Extract of Sweet Basil Restores Cholesterol and Triglycerides Metabolism in High Fat Diet-Fed Mice: A Comparison with Fenofibrate","volume":"3","author":"Harnafi","year":"2013","journal-title":"Biomed. Prev. Nutr."},{"key":"ref_16","first-page":"123","article-title":"Anti-Hyperglycaemic and Hypolipidemic Effects of Ocimum basilicum Aqueous Extract in Diabetic Rats","volume":"2","author":"Zeggwagh","year":"2007","journal-title":"AJPT"},{"key":"ref_17","first-page":"3501","article-title":"The Hypolipidemic and Antioxidant Actions of Aqueous Extracts of Ocimum basilicum and Ocimum suave in High Fat Fed Rats","volume":"6","author":"Umar","year":"2012","journal-title":"J. Med. Plants Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Tayebi, A., Rbah, Y., Moumou, M., Hadini, A., Aljutaily, T., Alfheeaid, H.A., Alayouni, R., Radhi, K.S., Barakat, H., and Milenkovic, D. (2025). Utilizing Sweet Basil Hydrodistillation By-Products to Boost Soybean Oil Stability and Combat Induced-Hyperlipidemia. Front. Sustain. Food Syst., 9.","DOI":"10.3389\/fsufs.2025.1668207"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/jn\/117.6.1011","article-title":"Lipoprotein Lipases, Lipoproteins and Tissue Lipids in Rats Fed Fish Oil or Coconut Oil","volume":"117","author":"Haug","year":"1987","journal-title":"J. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.18006\/2022.10(1).73.82","article-title":"Protective Effect of Crocus Sativus Stamens Extract on Gentamicin-Induced Nephrotoxicity and Oxidative Damage in Rat Kidney","volume":"10","author":"Mamri","year":"2022","journal-title":"J. Exp. Biol. Agric. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.17509\/ajse.v6i1.89789","article-title":"Valorization of Imidazolium-Based Salts as Next-Generation Antimicrobials: Integrated Biological Evaluation, ADMET, Molecular Docking, and Dynamics Studies","volume":"6","author":"Merimi","year":"2026","journal-title":"ASEAN J. Sci. Eng."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization, and Multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"W257","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: A Webserver for the Prediction of Toxicity of Chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"W513","DOI":"10.1093\/nar\/gkae303","article-title":"ProTox 3.0: A Webserver for the Prediction of Toxicity of Chemicals","volume":"52","author":"Banerjee","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Swanson, K., Walther, P., Leitz, J., Mukherjee, S., Wu, J.C., Shivnaraine, R.V., and Zou, J. (2024). ADMET-AI: A Machine Learning ADMET Platform for Evaluation of Large-Scale Chemical Libraries. Bioinformatics, 40.","DOI":"10.1093\/bioinformatics\/btae416"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Elbouzidi, A., Ouassou, H., Aherkou, M., Kharchoufa, L., Meskali, N., Baraich, A., Mechchate, H., Bouhrim, M., Idir, A., and Hano, C. (2022). LC\u2013MS\/MS Phytochemical Profiling, Antioxidant Activity, and Cytotoxicity of the Ethanolic Extract of Atriplex halimus L. against Breast Cancer Cell Lines: Computational Studies and Experimental Validation. Pharmaceuticals, 15.","DOI":"10.3390\/ph15091156"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1021\/jf990146l","article-title":"Antioxidant Activity of Plant Extracts Containing Phenolic Compounds","volume":"47","author":"Hopia","year":"1999","journal-title":"J. Agric. Food Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tox.2005.09.011","article-title":"Antioxidant Activity of Caffeic Acid (3,4-Dihydroxycinnamic Acid)","volume":"217","year":"2006","journal-title":"Toxicology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1021\/jf00049a007","article-title":"Antioxidant Activity of Various Tea Extracts in Relation to Their Antimutagenicity","volume":"43","author":"Yen","year":"1995","journal-title":"J. Agric. Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.20289\/zfdergi.431192","article-title":"Comparison of Phenolic Compounds and Antioxidant Activities of the Extracts of Grape Seed, Rosemary, Green Tea and Olive Leaf","volume":"56","year":"2019","journal-title":"Ege \u00dcniv. Ziraat Fak\u00fcltesi Derg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/ijfs.13331","article-title":"Polyphenolic Composition and In Vitro Antioxidant Activities of Native- and Tannase-treated Green Tea Extracts","volume":"52","author":"Ong","year":"2017","journal-title":"Int. J. Food Sci. Tech."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Bejenaru, L.E., Bi\u0163\u0103, A., Mogo\u015fanu, G.D., Segneanu, A.-E., Radu, A., Cioc\u00eelteu, M.V., and Bejenaru, C. (2024). Polyphenols Investigation and Antioxidant and Anticholinesterase Activities of Rosmarinus officinalis L. Species from Southwest Romania Flora. Molecules, 29.","DOI":"10.20944\/preprints202408.0135.v1"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Nie, J.-Y., Li, R., Wang, Y., Tan, J., Tang, S.-H., and Jiang, Z.-T. (2019). Antioxidant Activity Evaluation of Rosemary Ethanol Extract and Their Cellular Antioxidant Activity toward HeLa Cells. J. Food Biochem., 43.","DOI":"10.1111\/jfbc.12851"},{"key":"ref_34","first-page":"105","article-title":"Effects of Ocimum basilicum (Basil Seed) Extract on Blood Lipid Profile and Body Weight in Hyperlipidemic Mice","volume":"2","author":"Munir","year":"2025","journal-title":"GSAR J. Agric. Vet. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/ptr.1961","article-title":"Hypolipidaemic Activity of Aqueous Ocimum basilicum Extract in Acute Hyperlipidaemia Induced by Triton WR-1339 in Rats and Its Antioxidant Property","volume":"20","author":"Amrani","year":"2006","journal-title":"Phytother. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e181","DOI":"10.1016\/j.eclnm.2009.05.011","article-title":"Sweet Basil (Ocimum basilicum L.) Improves Lipid Metabolism in Hypercholesterolemic Rats","volume":"4","author":"Harnafi","year":"2009","journal-title":"e-SPEN Eur. e-J. Clin. Nutr. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Moumou, M., Tayebi, A., Hadini, A., Noman, O., Alhalmi, A., Ahmoda, H., Amrani, S., and Harnafi, H. (2025). Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of Ceratonia siliqua and Ocimum basilicum Rich Phenolic Formula on Lipid Metabolism and Plasma Lipoprotein Oxidation in Mice Fed a High-Fat Diet: A Follow-Up Study. Metabolites, 15.","DOI":"10.3390\/metabo15010036"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tem.2017.02.001","article-title":"SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis","volume":"28","author":"Linton","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1194\/jlr.M005371","article-title":"Apolipoprotein B-Containing Lipoprotein Assembly in Microsomal Triglyceride Transfer Protein-Deficient McA-RH7777 Cells","volume":"51","author":"Liu","year":"2010","journal-title":"J. Lipid Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Li, T., Guo, W., and Zhou, Z. (2022). Adipose Triglyceride Lipase in Hepatic Physiology and Pathophysiology. Biomolecules, 12.","DOI":"10.3390\/biom12010057"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ame2.12139","article-title":"Clinical Hematological and Biochemical Parameters in Swiss, BALB\/c, C57BL\/6 and B6D2F1 Mus musculus","volume":"3","author":"Bax","year":"2020","journal-title":"Anim. Model. Exp. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00580-025-03683-w","article-title":"Clinical Chemistry Reference Intervals for Swiss Albino Strain Mice Commonly Used in Scientific Studies","volume":"34","author":"Turkyilmaz","year":"2025","journal-title":"Comp. Clin. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1177\/0192623312447550","article-title":"Metabolic Adaptive ALT Isoenzyme Response in Livers of C57\/BL6 Mice Treated with Dexamethasone","volume":"40","author":"Reagan","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1478-3231.2008.01862.x","article-title":"Increased Hepatic Expression Is a Major Determinant of Serum Alanine Aminotransferase Elevation in Mice with Nonalcoholic Steatohepatitis","volume":"29","author":"Liu","year":"2009","journal-title":"Liver Int."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.redox.2012.10.001","article-title":"The Keap1-Nrf2 Pathway: Mechanisms of Activation and Dysregulation in Cancer","volume":"1","author":"Kansanen","year":"2013","journal-title":"Redox Biol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ichimura, Y., and Komatsu, M. (2018). Activation of P62\/SQSTM1\u2013Keap1\u2013Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer. Front. Oncol., 8.","DOI":"10.3389\/fonc.2018.00210"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.3390\/antiox12111980","article-title":"Demethylcalabaxanthone from Garcinia Mangostana Exerts Antioxidant Effects through the Activation of the Nrf2 Pathway as Assessed via Molecular Docking and Biological Evaluation","volume":"12","author":"Masullo","year":"2023","journal-title":"Antioxidants"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"101727","DOI":"10.1016\/j.isci.2020.101727","article-title":"PPAR\u03b1 Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates","volume":"23","author":"Kamata","year":"2020","journal-title":"iScience"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"19312","DOI":"10.1038\/srep19312","article-title":"Ligand-Based Virtual Screening and Inductive Learning for Identification of SIRT1 Inhibitors in Natural Products","volume":"6","author":"Sun","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1186\/s12967-023-04367-1","article-title":"Mitochondrial Metabolic Dysfunction and Non-Alcoholic Fatty Liver Disease: New Insights from Pathogenic Mechanisms to Clinically Targeted Therapy","volume":"21","author":"Zheng","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1038\/sj.emboj.7601633","article-title":"Metabolic Control of Muscle Mitochondrial Function and Fatty Acid Oxidation through SIRT1\/PGC-1\u03b1","volume":"26","author":"Rodgers","year":"2007","journal-title":"EMBO J."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Todisco, S., Santarsiero, A., Convertini, P., De Stefano, G., Gilio, M., Iacobazzi, V., and Infantino, V. (2022). PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH). Biology, 11.","DOI":"10.3390\/biology11050792"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Yu, L., Hong, W., Lu, S., Li, Y., Guan, Y., Weng, X., and Feng, Z. (2022). The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.780496"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Sun, T., Chen, M., Shen, H., Yin, P., Fan, L., Chen, X., Wu, J., Xu, Z., and Zhang, J. (2022). Predictive Value of LDL\/HDL Ratio in Coronary Atherosclerotic Heart Disease. BMC Cardiovasc. Disord., 22.","DOI":"10.1186\/s12872-022-02706-6"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2131\/jts.45.515","article-title":"Specificity of Transaminase Activities in the Prediction of Drug-Induced Hepatotoxicity","volume":"45","author":"Kobayashi","year":"2020","journal-title":"J. Toxicol. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3529149","DOI":"10.1155\/2016\/3529149","article-title":"Is Liver Enzyme Release Really Associated with Cell Necrosis Induced by Oxidant Stress?","volume":"2016","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbacli.2017.07.002","article-title":"Antioxidative Activity of High-Density Lipoprotein (HDL): Mechanistic Insights into Potential Clinical Benefit","volume":"8","author":"Brites","year":"2017","journal-title":"BBA Clin."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Denimal, D. (2024). Antioxidant and Anti-Inflammatory Functions of High-Density Lipoprotein in Type 1 and Type 2 Diabetes. Antioxidants, 13.","DOI":"10.3390\/antiox13010057"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"9905","DOI":"10.1111\/jcmm.16943","article-title":"Regulation of Autophagy Protects against Liver Injury in Liver Surgery-induced Ischaemia\/Reperfusion","volume":"25","author":"Hu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"24301","DOI":"10.1039\/D2RA02831J","article-title":"Compound Green Tea (CGT) Regulates Lipid Metabolism in High-Fat Diet Induced Mice","volume":"12","author":"Zhou","year":"2022","journal-title":"RSC Adv."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Downing, L.E., Heidker, R.M., Caiozzi, G.C., Wong, B.S., Rodriguez, K., Del Rey, F., and Ricketts, M.-L. (2015). A Grape Seed Procyanidin Extract Ameliorates Fructose-Induced Hypertriglyceridemia in Rats via Enhanced Fecal Bile Acid and Cholesterol Excretion and Inhibition of Hepatic Lipogenesis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0140267"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Madsen, S., Bak, S.Y., Yde, C.C., Jensen, H.M., Knudsen, T.A., B\u00e6ch-Laursen, C., Holst, J.J., Laustsen, C., and Hedemann, M.S. (2023). Unravelling Effects of Rosemary (Rosmarinus officinalis L.) Extract on Hepatic Fat Accumulation and Plasma Lipid Profile in Rats Fed a High-Fat Western-Style Diet. Metabolites, 13.","DOI":"10.3390\/metabo13090974"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1315202","DOI":"10.1155\/2020\/1315202","article-title":"Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats","volume":"2020","author":"Fki","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1139\/apnm-2023-0157","article-title":"Ameliorative Effects of Aqueous Extract from Rosemary on Oxidative Stress and Inflammation Pathways Caused by a High-Fat Diet in C57BL\/6 Mice","volume":"49","author":"Pereira","year":"2024","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"20","DOI":"10.31080\/ASPS.2020.04.0563","article-title":"Virtual Screening, Molecular Docking, and ADME\/T Analysis of Natural Product Library against Cell Invasion Protein SipB from Salmonella Enterica Serotype Typhi: In Silico Analysis","volume":"4","author":"Kumar","year":"2020","journal-title":"Act. Scie Pharma"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"113571","DOI":"10.1016\/j.fluid.2022.113571","article-title":"Prediction Surface Tension of Ionic Liquid\u2013Water Mixtures Using a Hybrid Group Contribution and Artificial Neural Network Method","volume":"563","author":"Fu","year":"2023","journal-title":"Fluid Phase Equilibria"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Gallagher, A., Kar, S., and Sep\u00falveda, M.S. (2023). Computational Modeling of Human Serum Albumin Binding of Per- and Polyfluoroalkyl Substances Employing QSAR, Read-Across, and Docking. Molecules, 28.","DOI":"10.3390\/molecules28145375"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural Products in Drug Discovery: Advances and Opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.1021\/acsomega.0c05846","article-title":"In Silico Prediction of Fraction Unbound in Human Plasma from Chemical Fingerprint Using Automated Machine Learning","volume":"6","author":"Mulpuru","year":"2021","journal-title":"ACS Omega"},{"key":"ref_70","first-page":"02","article-title":"Drug like Potential of Daidzein Using SwissADME Prediction: In Silico Approaches","volume":"2","author":"Sardar","year":"2023","journal-title":"Phytonutrients"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Khibech, O., Ouachekradi, M., Merzouki, M., Benabbou, A., Abadi, S., Karzazi, Y., Bouammalli, B., and Challioui, A. (2025). CNS-Safe Flavone Analogues as Dual SARS-CoV-2 Inhibitors: An Integrated in-silico Design Study. 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