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Methods: We analyzed data from 625 women participating in the PROGRESS study, a longitudinal pregnancy cohort. Women answered validated psychometric tests (i.e., EPDS, PSS and NLE) during the second or third trimester of pregnancy and provided serum samples at one-month postpartum for metabolomic assessment. Untargeted metabolomics were analyzed using chromatography high-resolution mass spectrometry (LC-HRMS). We used a metabolome-wide association study, using both traditional robust regressions and variance tests, to evaluate associations between pregnancy psychosocial stress and one-month postpartum serum metabolomics. Results: We found a few nominally significant associations between prenatal psychosocial stress scores and the maternal metabolome. However, these findings did not remain after adjusting for multiple testing, with the only exception of epiandrosterone glucuronide, a steroid hormone metabolite, and lithocholyltaurine, a lipid-like molecule. Conclusions: We did not find significant associations between prenatal psychosocial stress and postpartum serum metabolomic profiles, except for two metabolites showing suggestive associations warranting further investigation.<\/jats:p>","DOI":"10.3390\/metabo16050312","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:54:07Z","timestamp":1777654447000},"page":"312","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pregnancy Stress Exposures and Postpartum Serum Metabolomic Profiles in Mothers"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4330-9193","authenticated-orcid":false,"given":"Katherine","family":"Svensson","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3754-6691","authenticated-orcid":false,"given":"Sandra","family":"India-Aldana","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hachem","family":"Saddiki","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Petrick","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8096-443X","authenticated-orcid":false,"given":"Haibin","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6712-4847","authenticated-orcid":false,"given":"Carmen","family":"Hern\u00e1ndez-Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Department of Developmental Neurobiology, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3322-3334","authenticated-orcid":false,"given":"Martha M.","family":"T\u00e9llez-Rojo","sequence":"additional","affiliation":[{"name":"Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca 62100, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1180-6459","authenticated-orcid":false,"given":"Robert O.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4262-2807","authenticated-orcid":false,"given":"Rosalind J.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Colicino","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"},{"name":"Department of Biosciences, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12978-021-01209-5","article-title":"The relationship between social support and mental health problems during pregnancy: A systematic review and meta-analysis","volume":"18","author":"Bedaso","year":"2021","journal-title":"Reprod. 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