{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:35:55Z","timestamp":1785429355953,"version":"3.56.0"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CTS-944 Research Group of the Regional Government of Andalusia"},{"name":"Conselleria d\u2019Innovaci\u00f3, Universitats, Ci\u00e8ncia y Societat Digital of the Generalitat Valenciana","award":["CIPROM\/2021\/030"],"award-info":[{"award-number":["CIPROM\/2021\/030"]}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["PID2024-162731NB-I00"],"award-info":[{"award-number":["PID2024-162731NB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"award":["PID2024-162731NB-I00"],"award-info":[{"award-number":["PID2024-162731NB-I00"]}],"id":[{"id":"https:\/\/ror.org\/05r0vyz12","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Background\/Objectives: Many parasitic diseases remain without an effective treatment and cause many deaths worldwide. Leishmaniasis is a complex disease that belongs to the category of Neglected Tropical Diseases, as its treatment relies on outdated drugs that also lead to resistance and negative side-effects. To address this problem, two new chemical families have been tested in vitro against three of the most common parasites from the genus Leishmania. Methods: One family is formed by the polyamine tris(2-aminoethyl)amine functionalised either in one or its three primary amines with different aryl group, and the other is a group of azamacrocyclic cyclophanes containing either one or two aromatic spacers. Results: From the first family, only one compound showed activity against Leishmania donovani, and from the second family, three compounds were selective, two of them for Leishmania braziliensis and a different one against L. donovani, another parasite of the studied genus. Conclusions: The anti-Leishmania activity seems to be related to the compounds\u2019 ability to inhibit the iron superoxide dismutase activity and to alter the parasite metabolism by inhibiting glucose intake in L. braziliensis or by accelerating it in L. donovani and by attacking the parasite defences against ROS, both effects triggering a mitochondrial membrane depolarization that enhances damage, leading to cell death.<\/jats:p>","DOI":"10.3390\/metabo16050322","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:33:37Z","timestamp":1778589217000},"page":"322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Leishmania Fe-SOD and Glucose Metabolism with Tripodal and Pyridinacyclophane Polyamines as a Chemotherapeutic Strategy"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-9014","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Mart\u00edn-Montes","sequence":"first","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain"},{"name":"Facultad de Salud y Deporte, Universidad Alfonso X el Sabio-Mare Nostrum, Camino de la T\u00e9rmica, 90, 29004 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7400-5715","authenticated-orcid":false,"given":"Estefan\u00eda","family":"Delgado-Pinar","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica, Instituto de Ciencia Molecular, Universidad de Valencia, C\/Catedr\u00e1tico Jos\u00e9 Beltr\u00e1n 2, 46980 Paterna (Valencia), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bonastre","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica, Instituto de Ciencia Molecular, Universidad de Valencia, C\/Catedr\u00e1tico Jos\u00e9 Beltr\u00e1n 2, 46980 Paterna (Valencia), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9154-8842","authenticated-orcid":false,"given":"M. Paz","family":"Clares","sequence":"additional","affiliation":[{"name":"Departament de Qu\u00edmica Org\u00e0nica, Universitat de Val\u00e8ncia, Av. Vicent Andr\u00e9s Estell\u00e9s, 22, 46100 Burjassot (Val\u00e8ncia), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-1835","authenticated-orcid":false,"given":"Bego\u00f1a","family":"Verdejo","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica, Instituto de Ciencia Molecular, Universidad de Valencia, C\/Catedr\u00e1tico Jos\u00e9 Beltr\u00e1n 2, 46980 Paterna (Valencia), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-6961","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Mart\u00ednez-Camarena","sequence":"additional","affiliation":[{"name":"Departament de Qu\u00edmica F\u00edsica, Universitat de Val\u00e8ncia, Av. Vicent Andr\u00e9s Estell\u00e9s, 19, 46100 Burjassot (Valencia), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Ballesteros-Garrido","sequence":"additional","affiliation":[{"name":"Departament de Qu\u00edmica Org\u00e0nica, Universitat de Val\u00e8ncia, Av. Vicent Andr\u00e9s Estell\u00e9s, 22, 46100 Burjassot (Val\u00e8ncia), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6262-9344","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Mart\u00edn-Escolano","sequence":"additional","affiliation":[{"name":"Unidad de Infecci\u00f3n Viral e Inmunidad, Centro Nacional de Microbiolog\u00eda (CNM), Instituto de Salud Carlos III (ISCIII), 28220 Majadahonda, Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00aa Jos\u00e9","family":"Rosales-Lombardo","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4601-6505","authenticated-orcid":false,"given":"Enrique","family":"Garc\u00eda-Espa\u00f1a","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica, Instituto de Ciencia Molecular, Universidad de Valencia, C\/Catedr\u00e1tico Jos\u00e9 Beltr\u00e1n 2, 46980 Paterna (Valencia), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4316-2742","authenticated-orcid":false,"given":"Clotilde","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"ref_1","unstructured":"(2026, January 01). 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