{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:37:32Z","timestamp":1785418652423,"version":"3.56.0"},"reference-count":47,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2024\/07452-9"],"award-info":[{"award-number":["2024\/07452-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2019\/26070-1"],"award-info":[{"award-number":["2019\/26070-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2023\/16822-1"],"award-info":[{"award-number":["2023\/16822-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"award":["2024\/07452-9"],"award-info":[{"award-number":["2024\/07452-9"]}],"id":[{"id":"https:\/\/ror.org\/02ddkpn78","id-type":"ROR","asserted-by":"publisher"}]},{"award":["2019\/26070-1"],"award-info":[{"award-number":["2019\/26070-1"]}],"id":[{"id":"https:\/\/ror.org\/02ddkpn78","id-type":"ROR","asserted-by":"publisher"}]},{"award":["2023\/16822-1"],"award-info":[{"award-number":["2023\/16822-1"]}],"id":[{"id":"https:\/\/ror.org\/02ddkpn78","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01DE027648"],"award-info":[{"award-number":["R01DE027648"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["K02DE029531"],"award-info":[{"award-number":["K02DE029531"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Background\/Objectives: Fluoride (F) is widely used in public water fluoridation to prevent dental caries, and an optimal level of F has been linked to improved glucose metabolism in animal models. Per- and polyfluoroalkyl substances (PFAS), including fluorotelomer alcohols (FTOHs), are persistent environmental contaminants with potential effects on pancreatic function. Methods: This in vitro and in vivo study investigated the effects of 8:2 FTOH and F (NaF) on pancreatic \u03b2-cells, focusing on Ca2+ homeostasis, insulin secretion, and the GPR40 pathway. Results: Results showed that 8:2 FTOH alters Ca2+ influx in a dose-dependent, biphasic manner, enhancing it at low doses and inhibiting it at high doses, while F increased Ca2+ signaling at high doses. High-dose 8:2 FTOH also downregulated GPR40 protein in \u03b2TC-6 pancreatic cells and modulated pathways related to lipid metabolism, endoplasmic reticulum stress, and insulin regulation in the mouse pancreas by proteomic analyses (in vivo). Conclusions: These findings exploratory indicate that both PFAS and F can impact \u03b2-cell function through complex mechanisms, potentially affecting Ca2+ homeostasis. This work highlights the hormesis effect of F and provides novel insights into the pancreatic effects of environmentally relevant PFAS exposures, emphasizing the need for further mechanistic studies at low, human-relevant doses.<\/jats:p>","DOI":"10.3390\/metabo16070470","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:01:37Z","timestamp":1783339297000},"page":"470","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Fluoride and 8:2 FTOH on \u03b2-Cell Calcium Signaling and Insulin Homeostasis: An Exploratory Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7452-661X","authenticated-orcid":false,"given":"Juliana Sanches","family":"Trevizol","sequence":"first","affiliation":[{"name":"Department of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, 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33314, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanako","family":"Kuriki","sequence":"additional","affiliation":[{"name":"Department of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA"},{"name":"Department of Restorative Dentistry and Endodontology, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Brueckner","sequence":"additional","affiliation":[{"name":"Department of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Shindo","sequence":"additional","affiliation":[{"name":"Department of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, 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fluorinated alcohols present in various fluorinated materials","volume":"40","author":"Mabury","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/es0512475","article-title":"Sources, fate and transport of perfluorocarboxylates","volume":"40","author":"Prevedouros","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.scitotenv.2017.08.075","article-title":"Effects of microbial activity on perfluorinated carboxylic acids (PFCAs) generation during aerobic biotransformation of fluorotelomer alcohols in activated sludge","volume":"610\u2013611","author":"Yu","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integr. Environ. Assess. Manag."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1289\/ehp.10598","article-title":"Polyfluoroalkyl chemicals in the U.S. population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003\u20132004 and comparisons with NHANES 1999\u20132000","volume":"115","author":"Calafat","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1021\/es802827u","article-title":"Time trends and the influence of age and gender on serum concentrations of perfluorinated compounds in archived human samples","volume":"43","author":"Haug","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.chemosphere.2018.05.191","article-title":"Polybrominated diphenyl ethers and perfluorinated alkyl substances in blood serum of New Zealand adults, 2011\u20132013","volume":"208","author":"Coakley","year":"2018","journal-title":"Chemosphere"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Dixon, A., Rowan, E.G., Yackley, A.N., and Hines, E.P. (2024). PFAS Modulate Osmotic Signaling Independent of Gravimetric Changes in the Rat Uterus. Toxics, 12.","DOI":"10.3390\/toxics12030170"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1007\/s00204-016-1917-2","article-title":"Comparative hepatotoxicity of 6:2 fluorotelomer carboxylic acid and 6:2 fluorotelomer sulfonic acid, two fluorinated alternatives to long-chain perfluoroalkyl acids, on adult male mice","volume":"91","author":"Sheng","year":"2017","journal-title":"Arch. Toxicol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.tiv.2006.05.002","article-title":"Flow cytometric cell cycle analysis allows for rapid screening of estrogenicity in MCF-7 breast cancer cells","volume":"20","author":"Vanparys","year":"2006","journal-title":"Toxicol. Vitr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"115089","DOI":"10.1016\/j.ecoenv.2023.115089","article-title":"Perfluorooctanoic acid-induced cell death via the dual roles of ROS-MAPK\/ERK signaling in ameloblast-lineage cells","volume":"260","author":"Fujiwara","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3390\/jox11030008","article-title":"Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review","volume":"11","author":"Margolis","year":"2021","journal-title":"J. Xenobiot."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"138498","DOI":"10.1016\/j.scitotenv.2020.138498","article-title":"Perfluorooctane sulfonate acute exposure stimulates insulin secretion via GPR40 pathway","volume":"726","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10142-023-01055-7","article-title":"RefFinder: A web-based tool for comprehensively analyzing and identifying reference genes","volume":"23","author":"Xie","year":"2023","journal-title":"Funct. Integr. Genom."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"E383","DOI":"10.1152\/ajpendo.00358.2021","article-title":"Persistent organic pollutants and beta-cell toxicity: A comprehensive review","volume":"322","author":"Hoyeck","year":"2022","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"11029","DOI":"10.1038\/srep11029","article-title":"Perfluorooctanoic acid exposure for 28 days affects glucose homeostasis and induces insulin hypersensitivity in mice","volume":"5","author":"Yan","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.taap.2017.09.019","article-title":"Perfluorooctanoic acid exposure disturbs glucose metabolism in mouse liver","volume":"335","author":"Zheng","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1021\/acschemneuro.4c00652","article-title":"Investigating the Mechanism of Neurotoxic Effects of PFAS in Differentiated Neuronal Cells through Transcriptomics and Lipidomics Analysis","volume":"15","author":"Running","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41415-021-3775-4","article-title":"Understanding dental caries as a non-communicable disease","volume":"231","author":"Pitts","year":"2021","journal-title":"Brit Dent. J."},{"key":"ref_20","first-page":"CD010856","article-title":"Water fluoridation for the prevention of dental caries","volume":"10","author":"Walsh","year":"2024","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e20230036","DOI":"10.1590\/1678-7757-2023-0036","article-title":"Metabolic effect of low fluoride levels in the islets of NOD mice: Integrative morphological, immunohistochemical, and proteomic analyses","volume":"31","author":"Trevizol","year":"2023","journal-title":"J. Appl. Oral. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"126602","DOI":"10.1016\/j.chemosphere.2020.126602","article-title":"Effects of low-level fluoride exposure on glucose homeostasis in female NOD mice","volume":"254","author":"Trevizol","year":"2020","journal-title":"Chemosphere"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1177\/00220345950740011201","article-title":"Effect of Aging on Animal Response to Chronic Fluoride Exposure","volume":"74","author":"Dunipace","year":"1995","journal-title":"J. Dent. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ecoenv.2018.10.055","article-title":"Low-level fluoride exposure reduces glycemia in NOD mice","volume":"168","author":"Malvezzi","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1177\/0022034515581186","article-title":"Low-Level Fluoride Exposure Increases Insulin Sensitivity in Experimental Diabetes","volume":"94","author":"Lobo","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.1463-1326.2010.01299.x","article-title":"The role of peroxisome proliferator-activated receptor gamma in pancreatic beta cell function and survival: Therapeutic implications for the treatment of type 2 diabetes mellitus","volume":"12","author":"Gupta","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/01480540701873103","article-title":"90-day oral gavage toxicity study of 8-2 fluorotelomer alcohol in rats","volume":"31","author":"Ladics","year":"2008","journal-title":"Drug Chem. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Okamoto, M., Yamashita, S., Kuriki, N., Brueckner, S., Achong-Bowe, R., Mendonca, M., Trevizol, J.S., Fujiwara, N., Nakamura, S., and Shindo, S. (2026). Exposure to Per- and Polyfluoroalkyl Substances (PFAS) Causes Dental Developmental Anomalies: Underrecognized Risk of Fluoride Bioaccumulation. Environ. Sci. Technol. Artic. ASAP.","DOI":"10.1021\/acs.est.5c18166"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1074\/mcp.M500230-MCP200","article-title":"Absolute quantification of proteins by LCMSE: A virtue of parallel MS acquisition","volume":"5","author":"Silva","year":"2006","journal-title":"Mol. Cell Proteom."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Leite, A.L., Lobo, J.G.V.M., Pereira, H.A.B.D., Fernandes, M.S., Martini, T., Zucki, F., Sumida, D.H., Rigalli, A., and Buzalaf, M.A.R. (2014). Proteomic Analysis of Gastrocnemius Muscle in Rats with Streptozotocin-Induced Diabetes and Chronically Exposed to Fluoride. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0106646"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: Improving support for quantification data","volume":"47","author":"Csordas","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s12011-017-0984-4","article-title":"A Rat Experimental Study of the Relationship Between Fluoride Exposure and Sensitive Biomarkers","volume":"180","author":"Zhou","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Shindo, S., Nakamura, S., Rawas-Qalaji, M., Heidari, A., Pastore, M.R., Okamoto, M., Suzuki, M., Salinas, M., Minond, D., and Bontempo, A. (2024). Mechanosensing by Piezo1 regulates osteoclast differentiation via PP2A-Akt axis in periodontitis. bioRxiv.","DOI":"10.1101\/2024.09.04.611049"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"116495","DOI":"10.1016\/j.envpol.2021.116495","article-title":"Curcumin suppresses cell growth and attenuates fluoride-mediated Caspase-3 activation in ameloblast-like LS8 cells","volume":"273","author":"Fujiwara","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Yamashita, S., Okamoto, M., Mendonca, M., Fujiwara, N., Kitamura, E., Chang, C.S., Brueckner, S., Shindo, S., Kuriki, N., and Cooley, M.A. (2024). Fluoride Alters Gene Expression via Histone H3K27 Acetylation in Ameloblast-like LS8 Cells. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25179600"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1021\/acs.est.9b07295","article-title":"Perfluoroalkyl Substances Stimulate Insulin Secretion by Islet beta Cells via G Protein-Coupled Receptor 40","volume":"54","author":"Qin","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.6026\/973206300200065","article-title":"Serum albumin adjusted calcium and fluoride among type 2 diabetes mellitus patients","volume":"20","author":"Dubey","year":"2024","journal-title":"Bioinformation"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1021\/acs.estlett.6b00260","article-title":"Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants","volume":"3","author":"Hu","year":"2016","journal-title":"Environ. Sci. Technol. Lett."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1017\/S0954422410000168","article-title":"High-fat diet-induced obesity in animal models","volume":"23","author":"Hariri","year":"2010","journal-title":"Nutr. Res. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ha, S.E., Singh, R., Jin, B., Baek, G., Jorgensen, B.G., Zogg, H., Debnath, S., Park, H.S., Cho, H., and Watkins, C.M. (2024). miR-10a\/b-5p-NCOR2 Regulates Insulin-Resistant Diabetes in Female Mice. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202408.1944.v1"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000325107","article-title":"Fluoride metabolism","volume":"22","author":"Buzalaf","year":"2011","journal-title":"Monogr. Oral. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41580-020-00317-7","article-title":"Mechanisms controlling pancreatic islet cell function in insulin secretion","volume":"22","author":"Campbell","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"157255","DOI":"10.1016\/j.scitotenv.2022.157255","article-title":"A review of omics-based PFAS exposure studies reveals common biochemical response pathways","volume":"845","author":"Beale","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"105590","DOI":"10.1016\/j.aquatox.2020.105590","article-title":"Proteomics and lipidomics analyses reveal modulation of lipid metabolism by perfluoroalkyl substances in liver of Atlantic cod (Gadus morhua)","volume":"227","author":"Dale","year":"2020","journal-title":"Aquat. Toxicol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/toxsci\/kfaa148","article-title":"Perfluorooctanesulfonic Acid and Perfluorohexanesulfonic Acid Alter the Blood Lipidome and the Hepatic Proteome in a Murine Model of Diet-Induced Obesity","volume":"178","author":"Pfohl","year":"2020","journal-title":"Toxicol. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Pereira, H.A., Leite Ade, L., Charone, S., Lobo, J.G., Cestari, T.M., Peres-Buzalaf, C., and Buzalaf, M.A. (2013). Proteomic analysis of liver in rats chronically exposed to fluoride. PLoS ONE, 8.","DOI":"10.1371\/annotation\/54b8fb45-bb22-469e-96b3-77e99ba62b77"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.taap.2018.09.010","article-title":"Proposed mechanism for understanding the dose- and time-dependency of the effects of fluoride in the liver","volume":"358","author":"Pereira","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/16\/7\/470\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:49:35Z","timestamp":1783399775000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/16\/7\/470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["metabo16070470"],"URL":"https:\/\/doi.org\/10.3390\/metabo16070470","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]}}}