{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:28:35Z","timestamp":1791570515554,"version":"4.3.4"},"reference-count":18,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Background: Vitamin D deficiency is highly prevalent in individuals with severe obesity and may worsen after malabsorptive bariatric procedures. Adolescence represents a critical period of skeletal and metabolic maturation and may influence mineral\u2013hormonal adaptation after Roux-en-Y gastric bypass (RYGB). Objective: To investigate whether developmental stage influences longitudinal mineral\u2013hormonal adaptation after RYGB in adolescents and adults with severe obesity. Methods: This prospective observational cohort study included 120 participants undergoing RYGB: 60 adolescents (15\u201319 years) and 60 adults (20\u201349 years) with a history of severe obesity. Assessments were performed preoperatively and at 6 and 12 months postoperatively. Serum 25-hydroxyvitamin D, ionized calcium, phosphorus, and parathyroid hormone (PTH) were measured. Group comparisons were performed using non-parametric tests within a translational life-course framework. Results: Vitamin D inadequacy (&lt;30 ng\/mL) was highly prevalent at baseline in both groups (78.3% vs. 85.0%). Despite substantial weight loss in both cohorts, adolescents exhibited higher frequencies of hypocalcaemia and hypophosphataemia (p &lt; 0.001), progressive elevation of PTH levels, and a higher prevalence of secondary hyperparathyroidism at 12 months. Adults showed a comparatively less pronounced endocrine\u2013mineral response but also experienced persistent increases in PTH throughout follow-up. Vitamin D inadequacy remained highly prevalent in both groups despite standardized supplementation. Conclusions: Postoperative mineral\u2013hormonal adaptation after RYGB differs according to developmental stage. Adolescents exhibited greater endocrine\u2013mineral vulnerability during a critical period of skeletal maturation, suggesting that biological stage may influence postoperative adaptation beyond anthropometric response alone. These findings support developmental stage-specific monitoring and individualized postoperative management after metabolic surgery.<\/jats:p>","DOI":"10.3390\/metabo16070491","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:53:58Z","timestamp":1783932838000},"page":"491","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Developmental Stage Modulates Mineral\u2013Hormonal Adaptation After Roux-en-Y Gastric Bypass: A Translational Life-Course Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Mariana","family":"Luna","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8854-0129","authenticated-orcid":false,"given":"Bruno","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/ajcn\/72.3.690","article-title":"Decreased bioavailability of vitamin D in obesity","volume":"72","author":"Wortsman","year":"2000","journal-title":"Am. 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Tissue Int."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/16\/7\/491\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:15:40Z","timestamp":1784088940000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/16\/7\/491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":18,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["metabo16070491"],"URL":"https:\/\/doi.org\/10.3390\/metabo16070491","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]}}}