{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:53:18Z","timestamp":1790661198557,"version":"4.1.0"},"reference-count":79,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Osteosarcopenia combines low bone mass or skeletal fragility with sarcopenia, yet its metabolic biology is commonly assessed using single-time-point measurements. We conducted a structured narrative review of PubMed\/MEDLINE, Web of Science Core Collection, Embase and Scopus from inception through 28 June 2026, supplemented by ScienceDirect, Google Scholar and citation chaining. Evidence was classified as direct human osteosarcopenia evidence, indirect human evidence, preclinical evidence or conceptual inference. Here, chronometabolomics denotes time-anchored or repeated metabolomic profiling used to estimate variation in phase, amplitude and pathway coordination in relation to sleep, feeding, activity and endocrine timing. Direct human evidence remains scarce. Component-specific human studies and experimental models suggest, but do not establish, that aging, chronic disease and irregular schedules may alter glucose\u2013insulin, amino-acid, lipid, mitochondrial, redox-inflammatory, mineral-endocrine and microbial rhythms relevant to the bone\u2013muscle unit. Chronometabolomics is therefore an emerging research framework, not a validated diagnostic or therapeutic approach. Daytime light, sleep regularization, protein distribution, time-restricted eating, exercise timing and medication timing remain candidates for controlled trials rather than current clinical recommendations; safety evaluation must address frailty, low body mass index, malnutrition, kidney disease, diabetes, polypharmacy, falls and inadequate protein or calcium intake.<\/jats:p>","DOI":"10.3390\/metabo16080547","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:50:21Z","timestamp":1785757821000},"page":"547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rhythmic Metabolism in Osteosarcopenia: Emerging Evidence, a Chronometabolomic Framework for the Bone\u2013Muscle Unit, and Research Priorities"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5469-9800","authenticated-orcid":false,"given":"Yirui","family":"Chen","sequence":"first","affiliation":[{"name":"School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxin","family":"Gui","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7867-6807","authenticated-orcid":false,"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Sport Science, Beijing Sport University, Beijing 100084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0385-3243","authenticated-orcid":false,"given":"Yuqing","family":"Xue","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/jcsm.13392","article-title":"Global epidemiological features and impact of osteosarcopenia: A comprehensive meta-analysis and systematic review","volume":"15","author":"Chen","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment","volume":"21","author":"Chen","year":"2020","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e250234","DOI":"10.1530\/JOE-25-0234","article-title":"Muscle-bone biochemical crosstalk in osteosarcopenia: Focusing on mechanisms and potential therapeutic strategies","volume":"266","author":"Dong","year":"2025","journal-title":"J. Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3892\/etm.2023.11888","article-title":"Research advances in crosstalk between muscle and bone in osteosarcopenia (Review)","volume":"25","author":"Yu","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"ref_6","first-page":"36","article-title":"Muscle-bone crosstalk via endocrine signals and potential targets for osteosarcopenia-related fracture","volume":"43","author":"Sheng","year":"2023","journal-title":"J. Orthop. Transl."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e240093","DOI":"10.1530\/JOE-24-0093","article-title":"Bidirectional crosstalk between bone and muscle: The role of RANKL pathway in osteosarcopenia","volume":"262","author":"Jang","year":"2024","journal-title":"J. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00774-023-01472-5","article-title":"Crosstalk between muscle and bone","volume":"42","author":"Kaji","year":"2024","journal-title":"J. Bone Miner. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"155533","DOI":"10.1016\/j.metabol.2023.155533","article-title":"Epidemiology of sarcopenia: Prevalence, risk factors, and consequences","volume":"144","author":"Yuan","year":"2023","journal-title":"Metabolism"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"R113","DOI":"10.1530\/EJE-21-0553","article-title":"Mechanisms in Endocrinology: Local and systemic effects of glucocorticoids on metabolism: New lessons from animal models","volume":"185","author":"Swarbrick","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lambertucci, F., Castinetti, F., Martins, I., Lopez-Otin, C., and Kroemer, G. (2026). Pro-aging effects of chronic glucocorticoid signaling. Cell Metab.","DOI":"10.1016\/j.cmet.2026.05.002"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sagmeister, M.S., Harper, L., and Hardy, R.S. (2022). Cortisol excess in chronic kidney disease\u2014A review of changes and impact on mortality. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1075809"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00223-022-00965-1","article-title":"A Systematic Review of the Circadian Rhythm of Bone Markers in Blood","volume":"112","author":"Diemar","year":"2023","journal-title":"Calcif. Tissue Int."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Hancox, T.P.M., Skene, D.J., Dallmann, R., and Dunn, W.B. (2021). Tick-Tock Consider the Clock: The Influence of Circadian and External Cycles on Time of Day Variation in the Human Metabolome-A Review. Metabolites, 11.","DOI":"10.3390\/metabo11050328"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s41999-024-01129-0","article-title":"The role of the circadian timing system in sarcopenia in old age: A scoping review","volume":"16","author":"Palmese","year":"2025","journal-title":"Eur. Geriatr. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101700","DOI":"10.1016\/j.smrv.2022.101700","article-title":"Sleep, circadian biology and skeletal muscle interactions: Implications for metabolic health","volume":"66","author":"Morrison","year":"2022","journal-title":"Sleep Med. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e21611","DOI":"10.1096\/fj.202100143R","article-title":"Circadian misalignment disturbs the skeletal muscle lipidome in healthy young men","volume":"35","author":"Harmsen","year":"2021","journal-title":"FASEB J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111786","DOI":"10.1016\/j.celrep.2022.111786","article-title":"Divergent remodeling of the skeletal muscle metabolome over 24 h between young, healthy men and older, metabolically compromised men","volume":"41","author":"Harmsen","year":"2022","journal-title":"Cell Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s42003-023-05102-8","article-title":"Age-related changes in circadian regulation of the human plasma lipidome","volume":"6","author":"Rahman","year":"2023","journal-title":"Commun. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"zsaf320","DOI":"10.1093\/sleep\/zsaf320","article-title":"Metabolomic biomarkers of rest-activity rhythms in older women: Results from the Women\u2019s Health Initiative study","volume":"49","author":"Zhang","year":"2026","journal-title":"Sleep"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"zsaf319","DOI":"10.1093\/sleep\/zsaf319","article-title":"Metabolomic biomarkers of rest-activity rhythms in older men: Results from the Osteoporotic Fractures in Men (MrOS) study","volume":"49","author":"Zhang","year":"2026","journal-title":"Sleep"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"155268","DOI":"10.1016\/j.metabol.2022.155268","article-title":"Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients\u2014A randomized crossover trial","volume":"135","author":"Savikj","year":"2022","journal-title":"Metabolism"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100968","DOI":"10.1016\/j.jshs.2024.100968","article-title":"BMAL1\/PGC1\u03b14-FNDC5\/irisin axis impacts distinct outcomes of time-of-day resistance exercise","volume":"14","author":"Guo","year":"2025","journal-title":"J. Sport Health Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e70365","DOI":"10.1096\/fj.202402930R","article-title":"Diurnal variation in skeletal muscle mitochondrial function dictates time-of-day-dependent exercise capacity","volume":"39","author":"Khatri","year":"2025","journal-title":"FASEB J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e2504080122","DOI":"10.1073\/pnas.2504080122","article-title":"HIF1\u03b1 mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise","volume":"122","author":"Ehrlich","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e1017","DOI":"10.1210\/clinem\/dgae350","article-title":"Characterizing 24-Hour Skeletal Muscle Gene Expression Alongside Metabolic and Endocrine Responses Under Diurnal Conditions","volume":"110","author":"Smith","year":"2025","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1113\/JP285955","article-title":"BMAL1 and CLOCK proteins exhibit differential association with mitochondrial dynamics, protein synthesis pathways and muscle strength in human muscle","volume":"602","year":"2024","journal-title":"J. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6417","DOI":"10.1113\/JP285523","article-title":"Exercise training modifies skeletal muscle clock gene expression but not 24-hour rhythmicity in substrate metabolism of men with insulin resistance","volume":"602","author":"Harmsen","year":"2024","journal-title":"J. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e2422446122","DOI":"10.1073\/pnas.2422446122","article-title":"Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror\/Rev-erb balance and prevents premature sarcopenia","volume":"122","author":"Kelu","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1113\/JP285585","article-title":"More than the clock: Distinct regulation of muscle function and metabolism by PER2 and ROR\u03b1","volume":"602","author":"Mansingh","year":"2024","journal-title":"J. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"117521","DOI":"10.1016\/j.bone.2025.117521","article-title":"Rest-activity circadian rhythms and osteoporosis: A prospective cohort and Mendelian randomization study","volume":"198","author":"Zhao","year":"2025","journal-title":"Bone"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/s12967-021-03068-x","article-title":"Circadian rhythms affect bone reconstruction by regulating bone energy metabolism","volume":"19","author":"Luo","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Tian, Y., and Ming, J. (2022). The role of circadian rhythm in osteoporosis; a review. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.960456"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41418-021-00919-4","article-title":"Circadian rhythm modulates endochondral bone formation via MTR1\/AMPK\u03b21\/BMAL1 signaling axis","volume":"29","author":"Yu","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/s41418-023-01152-x","article-title":"Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Yin, Y., Tang, Q., Yang, J., Gui, S., Zhang, Y., Shen, Y., Zhou, X., Yu, S., Chen, G., and Sun, J. (2024). Endothelial BMAL1 decline during aging leads to bone loss by destabilizing extracellular fibrillin-1. J. Clin. Investig., 134.","DOI":"10.1172\/JCI176660"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e70582","DOI":"10.1111\/acel.70582","article-title":"Aging-Related Muscle Bmal1 Decline Contributes to Bone Loss in Mice via Enhancing IL-1\u03b1-Mediated Osteoclastogenesis","volume":"25","author":"Huang","year":"2026","journal-title":"Aging Cell"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Katoku-Kikyo, N., Vu, E.K., Mitchell, S., Karkache, I.Y., Bradley, E.W., and Kikyo, N. (2026). Circadian regulator PER1 inhibits osteoclastogenesis by activating inflammatory genes. J. Bone Miner. Res., zjag025.","DOI":"10.1093\/jbmr\/zjag025"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e70479","DOI":"10.1111\/acel.70479","article-title":"A Circadian Trough in Glucocorticoid Signaling Is Essential for Bone Health in Mice","volume":"25","author":"Smit","year":"2026","journal-title":"Aging Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"114019","DOI":"10.1016\/j.biopha.2022.114019","article-title":"Circadian clock genes as promising therapeutic targets for bone loss","volume":"157","author":"Qin","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1631\/jzus.B2100958","article-title":"Co-regulation of circadian clock genes and microRNAs in bone metabolism","volume":"23","author":"Li","year":"2022","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s41073-019-0064-8","article-title":"SANRA\u2014A scale for the quality assessment of narrative review articles","volume":"4","author":"Baethge","year":"2019","journal-title":"Res. Integr. Peer Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"108739","DOI":"10.1016\/j.maturitas.2025.108739","article-title":"Impact of diverse sleep characteristics on long-term skeletal muscle loss: A cohort study","volume":"202","author":"Hong","year":"2025","journal-title":"Maturitas"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e70145","DOI":"10.1111\/jpi.70145","article-title":"Sleep Regularity as a Potentially Modifiable Factor for Osteoporosis Prevention: Interaction with Genetic Susceptibility","volume":"78","author":"Zhao","year":"2026","journal-title":"J. Pineal. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/ggi.70110","article-title":"Are circadian rest-activity rhythms sex-specific markers of frailty risk in older adults? A narrative review","volume":"25","author":"Kim","year":"2025","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1113\/JP280756","article-title":"Nutrient timing and metabolic regulation","volume":"600","author":"Smith","year":"2022","journal-title":"J. Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1007\/s00125-022-05752-z","article-title":"Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: A randomised crossover trial","volume":"65","author":"Andriessen","year":"2022","journal-title":"Diabetologia"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Fernandez-Rodriguez, R., Garrido-Miguel, M., Bizzozero-Peroni, B., Diaz-Goni, V., Rodriguez-Gutierrez, E., Guzman-Pavon, M.J., Meseguer-Henarejos, A.B., and Torres-Costoso, A. (2024). Time-Restricted Eating and Bone Health: A Systematic Review with Meta-Analysis. Nutrients, 16.","DOI":"10.3390\/nu16060876"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s42255-024-01057-0","article-title":"Time of exercise differentially impacts bone growth in mice","volume":"6","author":"Yu","year":"2024","journal-title":"Nat. Metab."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Shao, G., Liu, X., and Li, Z. (2022). Assessment of the Therapeutic Potential of Melatonin for the Treatment of Osteoporosis Through a Narrative Review of Its Signaling and Preclinical and Clinical Studies. Front Pharmacol., 13.","DOI":"10.3389\/fphar.2022.866625"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e70079","DOI":"10.1111\/jpi.70079","article-title":"Relationship Between Urinary 6-Sulfatoxymelatonin Rhythms and the Bone Resorption Marker Amino-Terminal Cross-Linked Telopeptide of Collagen I in Blind Women","volume":"77","author":"Rahman","year":"2025","journal-title":"J. Pineal. Res."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Liu, M., Gong, J., Liu, Y., Yu, J., Hu, Z., and Liu, Z. (2025). Multi-omics reveals circadian regulation of bone homeostasis by gut microbiota metabolites: Mechanisms and chronotherapeutic implications. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1719445"},{"key":"ref_53","first-page":"100561","article-title":"Circadian rhythms regulate osteoclast recycling through gut microbiota-dependent Th17 cell expansion","volume":"10","author":"Ni","year":"2026","journal-title":"Curr. Res. Microb. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Sutton, E., and Pekovic-Vaughan, V. (2025). Time to Reset: The Interplay Between Circadian Rhythms and Redox Homeostasis in Skeletal Muscle Ageing and Systemic Health. Antioxidants, 14.","DOI":"10.3390\/antiox14091132"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e22133","DOI":"10.1096\/fj.202100707R","article-title":"Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle","volume":"36","author":"Wust","year":"2022","journal-title":"FASEB J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e71011","DOI":"10.1096\/fj.202501289R","article-title":"External Cues as Transducers of Peripheral Tissue-Specific Molecular Clocks to Regulate Systemic Circadian Rhythms and Metabolism","volume":"39","author":"Zhang","year":"2025","journal-title":"FASEB J."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Her, T.K., Li, J., Lin, H., Liu, D., Root, K.M., Regal, J.F., Alejandro, E.U., and Cao, R. (2024). Circadian Disruption across Lifespan Impairs Glucose Homeostasis and Insulin Sensitivity in Adult Mice. Metabolites, 14.","DOI":"10.3390\/metabo14020126"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"112588","DOI":"10.1016\/j.celrep.2023.112588","article-title":"Liver and muscle circadian clocks cooperate to support glucose tolerance in mice","volume":"42","author":"Smith","year":"2023","journal-title":"Cell Rep."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Mann, G., Mora, S., Madu, G., and Adegoke, O.A.J. (2021). Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.702826"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Carriel-Nesvara, A., Munoz-Medina, C., Deldicque, L., and Castro-Sepulveda, M. (2025). The role of the circadian clock in regulating mitochondrial dynamics and their impact on skeletal muscle function and metabolism. J. Physiol., JP289019.","DOI":"10.1113\/JP289019"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.tem.2025.11.001","article-title":"Uncovering the muscle clock-mitochondria axis through exercise","volume":"37","year":"2026","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e14382","DOI":"10.1111\/acel.14382","article-title":"Time-restricted feeding mediated modulation of microbiota leads to changes in muscle physiology in Drosophila obesity models","volume":"24","author":"Livelo","year":"2025","journal-title":"Aging Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1111\/jdi.13810","article-title":"Metabolic state switches between morning and evening in association with circadian clock in people without diabetes","volume":"13","author":"Fujimoto","year":"2022","journal-title":"J. Diabetes Investig."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1159\/000512685","article-title":"Cortisol Circadian Rhythm and Insulin Resistance in Muscle: Effect of Dosing and Timing of Hydrocortisone Exposure on Insulin Sensitivity in Synchronized Muscle Cells","volume":"111","author":"Negri","year":"2021","journal-title":"Neuroendocrinology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e12814","DOI":"10.1111\/jpi.12814","article-title":"The role of MEK1\/2 and MEK5 in melatonin-mediated actions on osteoblastogenesis, osteoclastogenesis, bone microarchitecture, biomechanics, and bone formation","volume":"73","author":"Munmun","year":"2022","journal-title":"J. Pineal. Res."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Chen, Y., Zhu, J., Gui, H., Liu, M., Zhang, Y., Wu, Z., Liu, C., and Wang, M. (2026). Linking Gut Microbiota, Mitochondrial Redox Dysfunction, and Ferroptosis in Cardiometabolic Diseases: A Narrative Review of Mechanistic Evidence and Redox-Targeted Interventions. Antioxidants, 15.","DOI":"10.3390\/antiox15070803"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.jamda.2023.04.032","article-title":"Sleep Duration and Sarcopenia: An Updated Systematic Review and Meta-Analysis","volume":"24","author":"Li","year":"2023","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s11325-025-03519-5","article-title":"Association between sleep disorders and sarcopenia in older outpatients in Vietnam","volume":"29","author":"Nguyen","year":"2025","journal-title":"Sleep Breath"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"112844","DOI":"10.1016\/j.exger.2025.112844","article-title":"Good sleep quality predicts a lower risk of osteoporosis in older adults: Evidence from the English longitudinal study of ageing","volume":"209","author":"Guo","year":"2025","journal-title":"Exp. Gerontol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Meisinger, C., and Freuer, D. (2026). Objectively measured sleep parameters and bone health: Results from the Human Phenotype Project (HPP) cohort. Osteoporos. Int.","DOI":"10.1007\/s00198-026-08041-2"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e13727","DOI":"10.1002\/jcsm.13727","article-title":"Cortisol Circadian Rhythm and Sarcopenia in Patients with Type 2 Diabetes: A Cross-Sectional Study","volume":"16","author":"Liu","year":"2025","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Chen, Y., Gui, H., Ma, K., Zhang, Z., Zhao, T., and Wang, M. (2026). Lifestyle-associated blood metabolic pathways and functional performance in cognitive aging. Sci. Rep.","DOI":"10.1038\/s41598-026-58782-7"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Qian, J., Huang, K., and Zhai, Q. (2025). Application of circadian rhythm in osteoporosis prevention and treatment: From light, diet, and exercise to chronotherapy. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1698016"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/gerona\/glad069","article-title":"Targeting Energy Intake and Circadian Biology to Engage Mechanisms of Aging in Older Adults with Obesity: Calorie Restriction and Time-Restricted Eating","volume":"78","author":"Panda","year":"2023","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/oby.23577","article-title":"The effects of time-restricted eating and weight loss on bone metabolism and health: A 6-month randomized controlled trial","volume":"31","author":"Papageorgiou","year":"2023","journal-title":"Obesity"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s13105-024-01066-3","article-title":"Aerobic exercise timing affects mitochondrial dynamics and insulin resistance by regulating the circadian clock protein expression and NAD+-SIRT1-PPAR\u03b1-MFN2 pathway in the skeletal muscle of high-fat-diet-induced diabetes mice","volume":"81","author":"Pourabdi","year":"2025","journal-title":"J. Physiol. Biochem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/10715762.2024.2348789","article-title":"The impact of aerobic exercise timing on BMAL1 protein expression and antioxidant responses in skeletal muscle of mice","volume":"58","author":"Xu","year":"2024","journal-title":"Free Radic. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1080\/07420528.2022.2050384","article-title":"The circadian clock regulates metabolic responses to physical exercise","volume":"39","author":"Cheng","year":"2022","journal-title":"Chronobiol. Int."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Silva, B.S.A., Uzeloto, J.S., Lira, F.S., Pereira, T., Coelho-E-Silva, M.J., and Caseiro, A. (2021). Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182412949"}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/16\/8\/547\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:08:13Z","timestamp":1785758893000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/16\/8\/547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,2]]},"references-count":79,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["metabo16080547"],"URL":"https:\/\/doi.org\/10.3390\/metabo16080547","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,2]]}}}