{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:22:12Z","timestamp":1787458932648,"version":"build-2736575974"},"reference-count":66,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Innovation Project of Guangxi Graduate Education","award":["YCBZ2026028"],"award-info":[{"award-number":["YCBZ2026028"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["32160457"],"award-info":[{"award-number":["32160457"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["32360470"],"award-info":[{"award-number":["32360470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Background: Wampee (Clausena lansium (Lour.) Skeels) is an understudied Rutaceae crop native to southern China, whose fruit features a complex aroma profile with simultaneous sour, sweet, bitter and astringent notes. Although bioactive compounds including flavonoids, alkaloids and volatile oils in wampee fruit have been partially characterized, the tissue-specific metabolic and transcriptional basis underlying its distinctive aroma formation remains largely unclear. Methods: We performed an integrated volatile metabolomic and transcriptomic analysis on the pericarp (peel) and flesh of wampee fruit across three cultivars (Shanyellowpi, Heijingang, Bingtangxin). Volatile metabolites were profiled via headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME-GC-MS), and transcriptome profiles were generated by RNA-Seq. Multi-omics integration was conducted using Procrustes analysis, gene\u2013metabolite correlation network construction and weighted gene co-expression network analysis (WGCNA). Results: A total of 288 volatile metabolites were identified, representing the most comprehensive volatile inventory for C. lansium reported to date. Principal component analysis and partial least squares discriminant analysis revealed distinct volatile profiles between pericarp and flesh; terpenoids were the dominant chemical class, accounting for 71.56\u201391.48% of total volatiles in pericarp and 61.88\u201367.22% in flesh. Notably, organoheterocyclic compounds were significantly enriched in Shanyellowpi flesh (40.45%), forming a cultivar-specific metabolic signature absent in the other two cultivars. Transcriptomic analysis showed that phenylpropanoid biosynthesis was the most significantly enriched pathway among differentially expressed genes, followed by monoterpene biosynthesis and sesquiterpenoid biosynthesis. Procrustes analysis demonstrated a strong global concordance between the two omics layers (M2 = 0.535, p &lt; 0.001). Gene\u2013metabolite correlation networks identified terpene synthase (TPS) genes (HP075360, HP217350) and oxidoreductase genes (SOD1, GST, 10HGO) as candidate co-regulators of terpenoid biosynthesis. WGCNA further prioritized TPS genes, cytochrome P450 genes and MYB transcription factor genes as key regulators driving volatile metabolic divergence between tissues. Conclusion: This study provides a comprehensive volatile and transcriptomic atlas of wampee fruit, and identifies tissue-specific and cultivar-specific metabolic signatures as well as their candidate regulatory genes. These findings advance our understanding of quality differentiation in Rutaceae fruits and lay a foundation for molecular breeding and flavor improvement of wampee.<\/jats:p>","DOI":"10.3390\/metabo16080598","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:20:36Z","timestamp":1787322036000},"page":"598","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Volatile Profiling and Transcriptomic Analysis of Peel and Flesh in Wampee (Clausena lansium (Lour.) Skeels)"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3427-7901","authenticated-orcid":false,"given":"Ruibing","family":"Xu","sequence":"first","affiliation":[{"name":"Key Laboratory Forest Tree Genetics & Breeding of Liaoning Province, College of Forestry, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshan","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Agro-Environment and Agro-Products Safety, National Demonstration Center for Experimental Plant Science Education, College of Agriculture, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5837-9994","authenticated-orcid":false,"given":"Gengrui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Agro-Environment and Agro-Products Safety, National Demonstration Center for Experimental Plant Science Education, College of Agriculture, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Agro-Environment and Agro-Products Safety, National Demonstration Center for Experimental Plant Science Education, College of Agriculture, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Shangrao Normal University, Shangrao 334001, China"},{"name":"Institute of Precision Medicine, Zhejiang Chinese Medical University, Hangzhou 311400, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jfca.2006.07.002","article-title":"Volatile components of the leaves, fruits and seeds of wampee [Clausena lansium (Lour.) Skeels]","volume":"20","author":"Chokeprasert","year":"2007","journal-title":"J. Food Compos. Anal."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Zhang, R., Zhou, J., Zhang, X., Hou, H., Liu, X., Yang, C., Shen, S., and Luo, J. (2024). Insights into tissue-specific specialized metabolism in wampee (Clausena lansium (Lour.) Skeels) varieties. Foods, 13.","DOI":"10.3390\/foods13193092"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1016\/j.jia.2024.07.043","article-title":"The Clausena lansium genome provides new insights into alkaloid diversity and the evolution of the methyltransferase family","volume":"23","author":"Wei","year":"2024","journal-title":"J. Integr. Agric."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102377","DOI":"10.1016\/j.fochx.2025.102377","article-title":"Changes in fruit quality parameters and volatile compounds in four wampee varieties at different ripening stages","volume":"27","author":"Mo","year":"2025","journal-title":"Food Chem. X"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"70744","DOI":"10.1111\/ppl.70744","article-title":"Transcriptome and Metabolome Analyses Reveal Anthocyanin, Sugar, and Organic Acid Changes in Red and Yellow Wampee Pericarps During Ripening","volume":"18","author":"Zhu","year":"2026","journal-title":"Physiol. Plant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1016\/j.ygeno.2021.09.007","article-title":"The Clausena lansium (wampee) genome reveal new insights into the carbazole alkaloids biosynthesis pathway","volume":"113","author":"Fan","year":"2021","journal-title":"Genomics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.foodchem.2017.03.040","article-title":"Comprehensive comparative analysis of volatile compounds in citrus fruits of different species","volume":"230","author":"Zhang","year":"2017","journal-title":"Food Chem."},{"key":"ref_8","first-page":"403","article-title":"Analysis of volatile compounds in baby banana peel and flesh (Musa acuminata AA Simmonds Cv. Bocadillo) in relation to the hyperpigmentation phenomenon","volume":"19","author":"Pino","year":"2019","journal-title":"Int. J. Fruit Sci."},{"key":"ref_9","first-page":"100053","article-title":"Temporal variation of volatile compounds from Sri Lankan mango (Mangifera indica L.) fruit during ripening","volume":"2","author":"Thiruchelvam","year":"2020","journal-title":"J. Agric. Food Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zidi, K., Kati, D.E., Bachir-bey, M., Genva, M., and Fauconnier, M.-L. (2021). Comparative study of fig volatile compounds using headspace solid-phase microextraction-gas chromatography\/mass spectrometry: Effects of cultivars and ripening stages. Front. Plant Sci., 12.","DOI":"10.3389\/fpls.2021.667809"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"109959","DOI":"10.1016\/j.plaphy.2025.109959","article-title":"Integrated analyses of the transcriptome and metabolome revealed the coloring mechanism of red-pericarp wampee","volume":"224","author":"Peng","year":"2025","journal-title":"Plant Physiol. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Adjei, M.O., Luo, R., Yu, H., Pang, Y., Wang, J., Zhang, Y., Ma, J., and Gao, A. (2025). Metabolome and transcriptome analysis reveal the pigments biosynthesis pathways in different color fruit peels of Clausena lansium L. Skeels. Front. Plant Sci., 15.","DOI":"10.3389\/fpls.2024.1496504"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.21273\/JASHS.141.4.339","article-title":"Volatile and nonvolatile flavor chemical evaluation of USDA orange-mandarin hybrids for comparison to sweet orange and mandarin fruit","volume":"141","author":"Bai","year":"2016","journal-title":"J. Am. Soc. Hortic. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Kaur, G., Abugu, M.O., and Tieman, D.M. (2023). The dissection of tomato flavor: Biochemistry, genetics, and omics. Front. Plant Sci., 14.","DOI":"10.3389\/fpls.2023.1144113"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"He, X., Ma, Y., Yi, G., Wen, Y., Zhang, Y., Zhang, H., and Zhang, L. (2019). Rapid and sensitive analysis of volatile components of different parts of Clausena lansium by ionic liquid-based headspace gas chromatography-mass spectrometry. Molecules, 24.","DOI":"10.3390\/molecules24010091"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Xu, Y., Zhu, C., Xu, C., Sun, J., Grierson, D., Zhang, B., and Chen, K. (2019). Integration of metabolite profiling and transcriptome analysis to provide a framework for understanding terpenoid biosynthesis in finger citron (Citrus medica var. sarcodactylis). Molecules, 24.","DOI":"10.3390\/molecules24142564"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/ffj.1703","article-title":"Contribution of volatile compounds to mango (Mangifera indica L.) aroma","volume":"21","author":"Pino","year":"2006","journal-title":"Flavour Fragr. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.foodchem.2019.03.064","article-title":"Characterization of the major aroma-active compounds in Keitt mango juice: Comparison among fresh, pasteurization and high hydrostatic pressure processing juices","volume":"289","author":"Zhang","year":"2019","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"112323","DOI":"10.1016\/j.foodres.2022.112323","article-title":"Morphology and mass spectrometry-based chemical profiling of peltate glandular trichomes on Mentha haplocalyx Briq leaves","volume":"164","author":"Liu","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"104922","DOI":"10.1016\/j.tifs.2025.104922","article-title":"Chemical compositions, health benefits, safety assessment, and industrial applications of wampee (Clausena lansium (Lour.) Skeels): A comprehensive review","volume":"157","author":"Ding","year":"2025","journal-title":"Trends Food Sci. Technol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Mas, M.C., Rambla, J.L., L\u00f3pez-Gresa, M.P., Bl\u00e1zquez, M.A., and Granell, A. (2019). Volatile Compounds in Citrus Essential Oils: A Comprehensive Review. Front. Plant Sci., 10.","DOI":"10.3389\/fpls.2019.00012"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1365-313X.2008.03446.x","article-title":"Biosynthesis of plant-derived flavor compounds","volume":"54","author":"Schwab","year":"2008","journal-title":"Plant J."},{"key":"ref_23","first-page":"322","article-title":"The chemistry of thermally generated aromas: Formation of pyrazines, furans, and thiazoles","volume":"705","author":"Mottram","year":"1998","journal-title":"ACS Symp. Ser."},{"key":"ref_24","unstructured":"Reineccius, G. (2018). The chemistry of flavor formation. Flavor Chemistry: Thirty Years of Progress, Springer."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1104\/pp.104.042580","article-title":"Functional characterization of enzymes forming volatile esters from strawberry and banana","volume":"135","author":"Beekwilder","year":"2004","journal-title":"Plant Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"798","DOI":"10.21273\/JASHS.120.5.798","article-title":"Characterizing NAD- and NADP-dependent alcohol dehydrogenase enzymes of strawberries","volume":"120","author":"Mitchell","year":"1995","journal-title":"J. Am. Soc. Hortic. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/tpj.12518","article-title":"The AAT1 locus is critical for the biosynthesis of esters contributing to \u2018ripe apple\u2019 flavour in \u2018Royal Gala\u2019 and \u2018Granny Smith\u2019 apples","volume":"78","author":"Souleyre","year":"2014","journal-title":"Plant J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"114399","DOI":"10.1016\/j.postharvbio.2026.114399","article-title":"The physiological dynamics and transcriptional regulation of postharvest aroma biosynthesis in apple fruit is mediated by a Dof transcription factor via the lipoxygenase pathway","volume":"239","author":"Li","year":"2026","journal-title":"Postharvest Biol. Technol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1126\/science.aal1556","article-title":"Aroma of Solanum pennellii enhances tomato flavor","volume":"355","author":"Tieman","year":"2017","journal-title":"Science"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pbi.2006.03.016","article-title":"Acyltransferases in plants: A good time to be BAHD","volume":"9","year":"2006","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev-arplant-062922-050122","article-title":"BAHD Company: The ever-expanding roles of the BAHD acyltransferase gene family in plants","volume":"74","author":"Moghe","year":"2023","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/mp\/ssp106","article-title":"Phenylpropanoid biosynthesis","volume":"3","author":"Vogt","year":"2010","journal-title":"Mol. Plant"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.phytochem.2007.06.005","article-title":"Tomato phenylacetaldehyde reductases catalyze the terminal step in the synthesis of the aroma volatile 2-phenylethanol","volume":"68","author":"Tieman","year":"2007","journal-title":"Phytochemistry"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Dardick, C., Callahan, A.M., Chiozzotto, R., Schaffer, R.J., Piagnani, M.C., and Scorza, R. (2010). Stone formation in peach fruit exhibits spatial coordination of the lignin and flavonoid pathways and similarity to Arabidopsis dehiscence. BMC Biol., 8.","DOI":"10.1186\/1741-7007-8-13"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"uhac085","DOI":"10.1093\/hr\/uhac085","article-title":"Peach fruit PpNAC1 activates PpFAD3-1 transcription to provide \u03c9-3 fatty acids for the synthesis of short-chain flavor volatiles","volume":"9","author":"Jin","year":"2022","journal-title":"Hort. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1365-313X.2011.04520.x","article-title":"The family of terpene synthases in plants: A mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom","volume":"66","author":"Chen","year":"2011","journal-title":"Plant J."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Karunanithi, P.S., and Zerbe, P. (2019). Terpene synthases as metabolic gatekeepers in plant chemical diversity. Front. Plant Sci., 10.","DOI":"10.3389\/fpls.2019.01166"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nchembio.158","article-title":"A unified mechanism of action for volatile isoprenoids in plant abiotic stress","volume":"5","author":"Vickers","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/jsfa.6689","article-title":"Features of citrus terpenoid production as revealed by carotenoid, limonoid and aroma profiles of two pummelos (Citrus maxima) with different flesh color","volume":"95","author":"Liu","year":"2015","journal-title":"J. Sci. Food Agric."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1104\/pp.106.3.1007","article-title":"Ozone, sulfur dioxide, and ultraviolet B have similar effects on mRNA accumulation of antioxidant genes in Nicotiana plumbaginifolia L.","volume":"106","author":"Willekens","year":"1994","journal-title":"Plant Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1365-313X.2008.03568.x","article-title":"Scopoletin is biosynthesized via ortho-hydroxylation of feruloyl CoA by a 2-oxoglutarate-dependent dioxygenase in Arabidopsis thaliana","volume":"55","author":"Kai","year":"2008","journal-title":"Plant J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0014-5793(01)03045-9","article-title":"Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis","volume":"508","author":"Collu","year":"2001","journal-title":"FEBS Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1590\/S1415-47572007000500011","article-title":"A genomic approach to characterization of the Citrus terpene synthase gene family","volume":"30","author":"Dornelas","year":"2007","journal-title":"Genet. Mol. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Yu, Q., Plotto, A., Baldwin, E.A., Bai, J., Huang, M., Yu, Y., Dhaliwal, H.S., and Gmitter, F.G. (2015). Proteomic and metabolomic analyses provide insight into production of volatile and non-volatile flavor components in mandarin hybrid fruit. BMC Plant Biol., 15.","DOI":"10.1186\/s12870-015-0466-9"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"117282","DOI":"10.1016\/j.foodres.2025.117282","article-title":"Integration of E-nose, volatilomic profiling, and transcriptomics reveals the mechanisms aroma formation during the ripening process of blueberries","volume":"221","author":"Jin","year":"2025","journal-title":"Food Res. Int."},{"key":"ref_46","unstructured":"Bach, T.J., and Rohmer, M. (2013). Involvement of compartmentalization in monoterpene and sesquiterpene biosynthesis in plants. Terpenes: Chemistry, Biological Role, and Clinical Applications, Springer."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Tian, Y., Liu, X., Chen, X., Wang, B., Dong, M., Chen, L., Yang, Z., Li, Y., and Sun, H. (2024). Integrated Untargeted Metabolome, Full-Length Sequencing and Transcriptome Analyses Reveal the Mechanism of Flavonoid Biosynthesis in Blueberry (Vaccinium spp.) Fruit. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084137"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Frey, M., Jochimsen, C.M., and Degenhardt, J. (2025). Cytochrome P450-Induced Backbone Rearrangements in Terpene Biosynthesis of Plants. Molecules, 30.","DOI":"10.3390\/molecules30173540"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1073\/pnas.95.8.4126","article-title":"Plant terpenoid synthases: Molecular biology and phylogenetic analysis","volume":"95","author":"Bohlmann","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"E017","DOI":"10.48130\/frures-0025-0008","article-title":"Effects of different dwarfing interstocks on the total phenols and compounds of polyphenols in the core of \u2018Huahong\u2019 apples","volume":"5","author":"Li","year":"2025","journal-title":"Fruit Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"111423","DOI":"10.1016\/j.plaphy.2026.111423","article-title":"Regulation of volatile biosynthesis in plants","volume":"236","author":"Schuurink","year":"2026","journal-title":"Plant Physiol. Biochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"8497259","DOI":"10.1155\/2020\/8497259","article-title":"Analysis of apple flavours: The use of volatile organic compounds to address cultivar differences and the correlation between consumer appreciation and aroma profiling","volume":"2020","author":"Roberts","year":"2020","journal-title":"J. Food Qual."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"100835","DOI":"10.1016\/j.fochx.2023.100835","article-title":"Comprehensive evaluation of aroma and taste properties of different parts from the wampee fruit","volume":"19","author":"Zhao","year":"2023","journal-title":"Food Chem. X"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.foodchem.2005.04.035","article-title":"Comparison of odour active compounds detected by gas-chromatography-olfactometry between hand-squeezed juices from different orange varieties","volume":"98","author":"Arena","year":"2006","journal-title":"Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1002\/fsn3.1841","article-title":"A comparative UPLC-Q-Orbitrap-MS untargeted metabolomics investigation of different parts of Clausena lansium (Lour.) Skeels","volume":"8","author":"Fan","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8200","DOI":"10.3390\/molecules18078200","article-title":"Advances in fruit aroma volatile research","volume":"18","author":"Zhang","year":"2013","journal-title":"Molecules"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.foodchem.2009.02.004","article-title":"Volatile characteristics of 50 peaches and nectarines evaluated by HP-SPME with GC-MS","volume":"116","author":"Wang","year":"2009","journal-title":"Food Chem."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Mas, M.C., Rambla, J.L., Alamar, M.C., Guti\u00e9rrez, A., and Granell, A. (2011). Comparative analysis of the volatile fraction of fruit juice from different Citrus species. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0022016"},{"key":"ref_59","first-page":"3165","article-title":"Monoterpene biosynthesis in lemon (Citrus limon). cDNA isolation and functional analysis of four monoterpene synthases","volume":"269","author":"Schwab","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Ma, J., Li, G., Chu, Y., Yue, H., Xu, Z., Wu, J., Li, X., and Jia, Y. (2025). Integrated Analysis of the Metabolome and Transcriptome During Apple Ripening to Highlight Aroma Determinants in Ningqiu Apples. Plants, 14.","DOI":"10.3390\/plants14081165"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Shan, Y., and Jin, S. (2025). Biosynthetic machinery to abiotic stress-driven emission: Decoding multilayer regulation of volatile terpenoids in plants. Antioxidants, 14.","DOI":"10.3390\/antiox14060673"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/tpj.13564","article-title":"Alcohol acyl transferase 1 links two distinct volatile pathways that produce esters and phenylpropenes in apple fruit","volume":"91","author":"Yauk","year":"2017","journal-title":"Plant J."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Kim, D.-S., Lee, S., Park, S.M., Yun, S.H., Gab, H.-S., Kim, S.S., and Kim, H.-J. (2021). Comparative metabolomics analysis of Citrus varieties. Foods, 10.","DOI":"10.3390\/foods10112826"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Eder, M., Sanchez, I., Brice, C., Camarasa, C., Legras, J.-L., and Dequin, S. (2018). QTL mapping of volatile compound production in Saccharomyces cerevisiae during alcoholic fermentation. BMC Genom., 19.","DOI":"10.1186\/s12864-018-4562-8"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Alqu\u00e9zar, B., Rodr\u00edguez, A., de la Pe\u00f1a, M., and Pe\u00f1a, L. (2017). Genomic Analysis of Terpene Synthase Family and Functional Characterization of Seven Sesquiterpene Synthases from Citrus sinensis. Front. Plant Sci., 8.","DOI":"10.3389\/fpls.2017.01481"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1104\/pp.105.4.1075","article-title":"Differential interactions of promoter elements in stress responses of the Arabidopsis Adh gene","volume":"105","author":"Dolferus","year":"1994","journal-title":"Plant Physiol."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/16\/8\/598\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:12:46Z","timestamp":1787458366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/16\/8\/598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":66,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["metabo16080598"],"URL":"https:\/\/doi.org\/10.3390\/metabo16080598","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]}}}