{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:56:08Z","timestamp":1791233768011,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204142"],"award-info":[{"award-number":["82204142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82204142"],"award-info":[{"award-number":["82204142"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010882","name":"Tianjin Education Commission for Higher Education","doi-asserted-by":"publisher","award":["2021KJ118"],"award-info":[{"award-number":["2021KJ118"]}],"id":[{"id":"10.13039\/501100010882","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lindh\u00e9s Advokatbyr\u00e5 AB","award":["LA2025-0119"],"award-info":[{"award-number":["LA2025-0119"]}]},{"DOI":"10.13039\/100010771","name":"Loo och Hans Ostermans Foundation","doi-asserted-by":"publisher","award":["FS-2025:0009"],"award-info":[{"award-number":["FS-2025:0009"]}],"id":[{"id":"10.13039\/100010771","id-type":"DOI","asserted-by":"publisher"}]},{"award":["FS-2025:0009"],"award-info":[{"award-number":["FS-2025:0009"]}],"id":[{"id":"https:\/\/ror.org\/03ahe1y49","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010815","name":"Stiftelsen f\u00f6r \u00e5lderssjukdomar","doi-asserted-by":"publisher","award":["2025-02164"],"award-info":[{"award-number":["2025-02164"]}],"id":[{"id":"10.13039\/100010815","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009673","name":"Gun and Bertil Stohne Foundation","doi-asserted-by":"publisher","award":["2025-088"],"award-info":[{"award-number":["2025-088"]}],"id":[{"id":"10.13039\/100009673","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2025-088"],"award-info":[{"award-number":["2025-088"]}],"id":[{"id":"https:\/\/ror.org\/00cv16a87","id-type":"ROR","asserted-by":"publisher"}]},{"name":"National College Students\u2019 Innovation and Entrepreneurship Training Program","award":["202610063002"],"award-info":[{"award-number":["202610063002"]}]},{"DOI":"10.13039\/501100010882","name":"Tianjin Municipal Education Commission project","doi-asserted-by":"publisher","award":["2022KJ143"],"award-info":[{"award-number":["2022KJ143"]}],"id":[{"id":"10.13039\/501100010882","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2022KJ143"],"award-info":[{"award-number":["2022KJ143"]}],"id":[{"id":"https:\/\/ror.org\/01z7y3r39","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Background\/Objectives: Aflatoxin B1 (AFB1) contamination of maize and peanut is influenced by fungal responses to environmental and food-matrix cues, but the transcriptional coordination of redox adaptation, lipid metabolism, and aflatoxin biosynthesis remains unresolved. This study examined whether an expression-defined redox\u2013lipid state is associated with high relative aflatoxin biosynthetic activity in Aspergillus flavus. Methods: A cross-dataset secondary analysis integrated 18 analytical datasets (247 samples) derived from eight public source records spanning defined-medium, maize, and peanut systems. Harmonized expression profiles were used to derive an aflatoxin biosynthetic activity score (ABAS), oxidative-stress adaptation score (OSAS), and lipid metabolic reprogramming score (LMRS). ABAS is an expression-derived relative score, not a direct measure of biosynthetic flux or accumulated toxin. Dataset-aware mixed-effects models evaluated the OSAS\u2013ABAS association and the linear OSAS \u00d7 LMRS interaction. Results: ABAS correlated with matched AFB1 measurements in 54 samples (Pearson r=0.734, p=2.70\u00d710\u221210). The quadratic OSAS term was negative (\u03b2=\u22120.434, 95% CI \u22120.502 to \u22120.366; p&lt;0.001), with maximum predicted ABAS near 0.81 SD on the pooled within-dataset-standardized OSAS scale. Separately, the linear OSAS \u00d7 LMRS interaction was positive (\u03b2=0.284, 95% CI 0.198\u20130.370; p&lt;0.001), and the high-OSAS\/high-LMRS quadrant had the greatest adjusted mean ABAS (0.789, 95% CI 0.661\u20130.917). Candidate prioritization recovered established regulators and nominated redox- and lipid-associated nodes. Conclusions: The findings identify an associative transcriptional signature across heterogeneous food-relevant conditions and provide focused hypotheses for prospective validation using direct toxin, redox, lipid, flux, and functional measurements.<\/jats:p>","DOI":"10.3390\/metabo16090652","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:12:25Z","timestamp":1788783145000},"page":"652","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Redox\u2013Lipid Transcriptional State Is Associated with High Aflatoxin Biosynthetic Activity in Aspergillus flavus"],"prefix":"10.3390","volume":"16","author":[{"given":"Yirui","family":"Chen","sequence":"first","affiliation":[{"name":"School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Jinghai District, Tianjin 301617, China"},{"name":"Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"software","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Hongxin","family":"Gui","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Jinghai District, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"}]},{"given":"Kai","family":"Ma","sequence":"additional","affiliation":[{"name":"Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Jinghai District, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Ruochen","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Jinghai District, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Zhijian","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Jinghai District, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7812-7786","authenticated-orcid":false,"given":"Mengyang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Jinghai District, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Rongrong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Jinghai District, Tianjin 301617, China"},{"name":"Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Tomtebodav\u00e4gen 18A, Floor 10, SE-171 65 Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2412757","DOI":"10.1002\/advs.202412757","article-title":"Aspergillus Mycotoxins: The Major Food Contaminants","volume":"12","author":"Xue","year":"2025","journal-title":"Adv. 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