{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:20:18Z","timestamp":1773476418071,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R004803\/1"],"award-info":[{"award-number":["MR\/R004803\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Eating disorders are severe illnesses characterized by both psychiatric and metabolic factors. We explored the prospective role of metabolic risk in eating disorders in a UK cohort (n = 2929 participants), measuring 158 metabolic traits in non-fasting EDTA-plasma by nuclear magnetic resonance. We associated metabolic markers at 7 years (exposure) with risk for anorexia nervosa and binge-eating disorder (outcomes) at 14, 16, and 18 years using logistic regression adjusted for maternal education, child\u2019s sex, age, body mass index, and calorie intake at 7 years. Elevated very low-density lipoproteins, triglycerides, apolipoprotein-B\/A, and monounsaturated fatty acids ratio were associated with lower odds of anorexia nervosa at age 18, while elevated high-density lipoproteins, docosahexaenoic acid and polyunsaturated fatty acids ratio, and fatty acid unsaturation were associated with higher risk for anorexia nervosa at 18 years. Elevated linoleic acid and n-6 fatty acid ratios were associated with lower odds of binge-eating disorder at 16 years, while elevated saturated fatty acid ratio was associated with higher odds of binge-eating disorder. Most associations had large confidence intervals and showed, for anorexia nervosa, different directions across time points. Overall, our results show some evidence for a role of metabolic factors in eating disorders development in adolescence.<\/jats:p>","DOI":"10.3390\/metabo9090191","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T10:55:21Z","timestamp":1568890521000},"page":"191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8923-0117","authenticated-orcid":false,"given":"Diana","family":"Santos Ferreira","sequence":"first","affiliation":[{"name":"Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, UK"},{"name":"Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-8287","authenticated-orcid":false,"given":"Christopher","family":"H\u00fcbel","sequence":"additional","affiliation":[{"name":"Social, Genetic &amp; Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &amp; Neuroscience, King\u2019s College London, London SE5 8AF, UK"},{"name":"UK National Institute for Health Research (NIHR) Biomedical Research Centre, South London and Maudsley Hospital, London SE5 8AF, UK"},{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Herle","sequence":"additional","affiliation":[{"name":"University College London, Great Ormond Street Institute of Child Health, London WC1N 1EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdulkadir","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, University of Geneva, CH\u20131205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Loos","sequence":"additional","affiliation":[{"name":"Icahn Mount Sinai School of Medicine, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Bryant-Waugh","sequence":"additional","affiliation":[{"name":"University College London, Great Ormond Street Institute of Child Health, London WC1N 1EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Bulik","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77 Stockholm, Sweden"},{"name":"Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"},{"name":"Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"De Stavola","sequence":"additional","affiliation":[{"name":"University College London, Great Ormond Street Institute of Child Health, London WC1N 1EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Lawlor","sequence":"additional","affiliation":[{"name":"Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, UK"},{"name":"Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK"},{"name":"Bristol National Institute of Health Research Biomedical Research Centre, Bristol BS1 3NU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5571-2273","authenticated-orcid":false,"given":"Nadia","family":"Micali","sequence":"additional","affiliation":[{"name":"University College London, Great Ormond Street Institute of Child Health, London WC1N 1EH, UK"},{"name":"Department of Psychiatry, Faculty of Medicine, University of Geneva, CH\u20131205 Geneva, Switzerland"},{"name":"Child and Adolescent Psychiatry Division, Department of Child and Adolescent Health, Geneva University Hospital, CH\u20131205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/eat.20369","article-title":"Outcomes of eating disorders: A systematic review of the literature","volume":"40","author":"Berkman","year":"2007","journal-title":"Int. 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