{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:21:10Z","timestamp":1791573670044,"version":"4.3.4"},"reference-count":71,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Cells efficiently adjust their metabolism according to the abundance of nutrients and energy. The ability to switch cellular metabolism between anabolic and catabolic processes is critical for cell growth. Glucose-6 phosphate is the first intermediate of glucose metabolism and plays a central role in the energy metabolism of the liver. It acts as a hub to metabolically connect glycolysis, the pentose phosphate pathway, glycogen synthesis, de novo lipogenesis, and the hexosamine pathway. In this review, we describe the metabolic fate of glucose-6 phosphate in a healthy liver and the metabolic reprogramming occurring in two pathologies characterized by a deregulation of glucose homeostasis, namely type 2 diabetes, which is characterized by fasting hyperglycemia; and glycogen storage disease type I, where patients develop severe hypoglycemia during short fasting periods. In these two conditions, dysfunction of glucose metabolism results in non-alcoholic fatty liver disease, which may possibly lead to the development of hepatic tumors. Moreover, we also emphasize the role of the transcription factor carbohydrate response element-binding protein (ChREBP), known to link glucose and lipid metabolisms. In this regard, comparing these two metabolic diseases is a fruitful approach to better understand the key role of glucose-6 phosphate in liver metabolism in health and disease.<\/jats:p>","DOI":"10.3390\/metabo9120282","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T11:06:03Z","timestamp":1574247963000},"page":"282","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":159,"title":["Glucose-6 Phosphate, a Central Hub for Liver Carbohydrate Metabolism"],"prefix":"10.3390","volume":"9","author":[{"given":"Fabienne","family":"Rajas","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1213, F-69008 Lyon, France"},{"name":"Universit\u00e9 de Lyon, F-69008 Lyon, France"},{"name":"Universit\u00e9 Lyon 1, F-69622 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Gautier-Stein","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1213, F-69008 Lyon, France"},{"name":"Universit\u00e9 de Lyon, F-69008 Lyon, France"},{"name":"Universit\u00e9 Lyon 1, F-69622 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Mithieux","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1213, F-69008 Lyon, France"},{"name":"Universit\u00e9 de Lyon, F-69008 Lyon, France"},{"name":"Universit\u00e9 Lyon 1, F-69622 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1096\/fasebj.8.6.8168691","article-title":"Short-term control of glucokinase activity: Role of a regulatory protein","volume":"8","author":"Detheux","year":"1994","journal-title":"FASEB J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev-nutr-071715-051145","article-title":"Hormonal and Metabolite Regulation of Hepatic Glucokinase","volume":"36","author":"Agius","year":"2016","journal-title":"Annu. 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