{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:07:33Z","timestamp":1773677253836,"version":"3.50.1"},"reference-count":55,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["19-53-80047 BRICS_t"],"award-info":[{"award-number":["19-53-80047 BRICS_t"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51961145108"],"award-info":[{"award-number":["51961145108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61975035"],"award-info":[{"award-number":["61975035"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51850410502"],"award-info":[{"award-number":["51850410502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["ECR\/2017\/002649"],"award-info":[{"award-number":["ECR\/2017\/002649"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DST\/ICD\/BRICS\/Pilot Call 3\/BioTheraBubble\/2019"],"award-info":[{"award-number":["DST\/ICD\/BRICS\/Pilot Call 3\/BioTheraBubble\/2019"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Microbubbles are intravascular contrast agents clinically used in diagnostic sonography, echocardiography, and radiology imaging applications. However, up to date, the idea of creating microbubbles with multiple functionalities (e.g., multimodal imaging, photodynamic therapy) remained a challenge. One possible solution is the modification of bubble shells by introducing specific compounds responsible for such functions. In the present work, air-core microbubbles with the shell consisting of bovine serum albumin, albumin-coated gold nanocages, and zinc phthalocyanine were prepared using the sonication method. Various physicochemical parameters such as stability over time, size, and concentration were investigated to prove the potential use of these microbubbles as contrast agents. This work shows that hybrid microbubbles have all the necessary properties for multimodal imaging (ultrasound, raster-scanning microscopy, and fluorescence tomography), which demonstrate superior characteristics for potential theranostic and related biomedical applications.<\/jats:p>","DOI":"10.3390\/mi12101161","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T21:40:30Z","timestamp":1632778830000},"page":"1161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging"],"prefix":"10.3390","volume":"12","author":[{"given":"Elizaveta A.","family":"Maksimova","sequence":"first","affiliation":[{"name":"Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman A.","family":"Barmin","sequence":"additional","affiliation":[{"name":"Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polina G.","family":"Rudakovskaya","sequence":"additional","affiliation":[{"name":"Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5288-4157","authenticated-orcid":false,"given":"Olga A.","family":"Sindeeva","sequence":"additional","affiliation":[{"name":"Center for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-168X","authenticated-orcid":false,"given":"Ekaterina S.","family":"Prikhozhdenko","sequence":"additional","affiliation":[{"name":"Science Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8302-5646","authenticated-orcid":false,"given":"Alexey M.","family":"Yashchenok","sequence":"additional","affiliation":[{"name":"Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3996-5750","authenticated-orcid":false,"given":"Boris N.","family":"Khlebtsov","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Physiology of Plants and Microorganisms, 410049 Saratov, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander A.","family":"Solovev","sequence":"additional","affiliation":[{"name":"Department of Materials Science, Fudan University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0525-7177","authenticated-orcid":false,"given":"Gaoshan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Materials Science, Fudan University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfeng","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Materials Science, Fudan University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Kanti Dey","sequence":"additional","affiliation":[{"name":"Discipline of Physics, Indian Institute of Technology Gandhinagar Gandhinagar, Gujarat 382355, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry A.","family":"Gorin","sequence":"additional","affiliation":[{"name":"Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1088\/0031-9155\/51\/13\/R06","article-title":"Ultrasound imaging","volume":"51","author":"Wells","year":"2006","journal-title":"Phys. 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