{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:20:35Z","timestamp":1790216435603,"version":"4.1.0"},"reference-count":27,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61661014, 61627807, 81873913, 21661010, 61301038"],"award-info":[{"award-number":["61661014, 61627807, 81873913, 21661010, 61301038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Quercetin (Qu) is one of the most abundant flavonoids in the human diet. High concentrations of Qu can easily cause adverse effects and induce inflammation, joint pain and stiffness. In this study, Heme was used as a sensitive element and deposited and formed nanorods on a glassy carbon electrode (GCE) for the detection of Qu. The Heme\/GCE sensor was characterized using scanning electron microscopy (SEM), cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) techniques. Under optimized conditions, the developed sensor presented a linear concentration ranging from 0.1 to 700 \u03bcmol\u00b7L\u22121 according to the CV and DPV methods. The detection limit for the sensor was 0.134 \u03bcmol\u00b7L\u22121 and its sensitivity was 0.12 \u03bcA\u00b7\u03bcM\u22121\u00b7cm\u22122, which were obtained from CV analysis. Through DPV analysis we obtained a detection limit of 0.063 \u03bcmol\u00b7L\u22121 and a sensitivity of 0.09 \u03bcA\u00b7\u03bcM\u22121\u00b7cm\u22122. Finally, this sensor was used to detect the Qu concentration in loquat leaf powder extract, with recovery between 98.55\u2013102.89% and total R.S.D. lower than 3.70%. The constructed electrochemical sensor showed good anti-interference, repeatability and stability, indicating that it is also usable for the rapid detection of Qu in actual samples.<\/jats:p>","DOI":"10.3390\/mi12121519","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T11:00:23Z","timestamp":1638874823000},"page":"1519","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Convenient Heme Nanorod Modified Electrode for Quercetin Sensing by Two Common Electrochemical Methods"],"prefix":"10.3390","volume":"12","author":[{"given":"Jin-Guang","family":"Liu","sequence":"first","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Zheng","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Min","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5943-8547","authenticated-orcid":false,"given":"Guo-Cheng","family":"Han","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Zhen","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhencheng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.lfs.2019.03.055","article-title":"Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer\u2019s disease","volume":"224","author":"Zaplatic","year":"2019","journal-title":"Life Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.ejmech.2018.06.053","article-title":"Therapeutic potential of quercetin as a cardiovascular agent","volume":"155","author":"Patel","year":"2018","journal-title":"Eur. 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