{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:47:52Z","timestamp":1790682472018,"version":"4.1.0"},"reference-count":87,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EC Horizon 2020 FETPROACT-2018-01 NEUHEART Project","award":["824071"],"award-info":[{"award-number":["824071"]}]},{"name":"Italian National Institute for Insurance against Accidents at Work (INAIL Centro Protesi, Budrio) BIOSUP Project","award":["824071"],"award-info":[{"award-number":["824071"]}]},{"name":"Bertarelli Foundation","award":["824071"],"award-info":[{"award-number":["824071"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Implantable flexible neural interfaces (IfNIs) are capable of directly modulating signals of the central and peripheral nervous system by stimulating or recording the action potential. Despite outstanding results in acute experiments on animals and humans, their long-term biocompatibility is hampered by the effects of foreign body reactions that worsen electrical performance and cause tissue damage. We report on the fabrication of a polysaccharide nanostructured thin film as a coating of polyimide (PI)-based IfNIs. The layer-by-layer technique was used to coat the PI surface due to its versatility and ease of manufacturing. Two different LbL deposition techniques were tested and compared: dip coating and spin coating. Morphological and physiochemical characterization showed the presence of a very smooth and nanostructured thin film coating on the PI surface that remarkably enhanced surface hydrophilicity with respect to the bare PI surface for both the deposition techniques. However, spin coating offered more control over the fabrication properties, with the possibility to tune the coating\u2019s physiochemical and morphological properties. Overall, the proposed coating strategies allowed the deposition of a biocompatible nanostructured film onto the PI surface and could represent a valid tool to enhance long-term IfNI biocompatibility by improving tissue\/electrode integration.<\/jats:p>","DOI":"10.3390\/mi13050692","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T22:20:06Z","timestamp":1651184406000},"page":"692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces"],"prefix":"10.3390","volume":"13","author":[{"given":"Eugenio","family":"Redolfi Riva","sequence":"first","affiliation":[{"name":"The BioRobotics Institute, Department of Excellence in Robotics and AI, Scuola Superiore Sant\u2019Anna, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"D\u2019Alessio","sequence":"additional","affiliation":[{"name":"The BioRobotics Institute, Department of Excellence in Robotics and AI, Scuola Superiore Sant\u2019Anna, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvestro","family":"Micera","sequence":"additional","affiliation":[{"name":"The BioRobotics Institute, Department of Excellence in Robotics and AI, Scuola Superiore Sant\u2019Anna, 56127 Pisa, Italy"},{"name":"Translational Neuroengineering, Centre for Neuroprosthetics and Institute of Bioengineering, School of Engineering, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1000 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.neuron.2020.01.039","article-title":"Advanced Neurotechnologies for the Restoration of Motor Function","volume":"105","author":"Micera","year":"2020","journal-title":"Neuron"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrneurol.2015.229","article-title":"Clinical Assessment of Social Cognitive Function in Neurological Disorders","volume":"12","author":"Henry","year":"2016","journal-title":"Nat. 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