{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:12:31Z","timestamp":1790817151216,"version":"4.1.0"},"reference-count":158,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"LazioInnova","award":["85-2017-15004"],"award-info":[{"award-number":["85-2017-15004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Failure of tissues and organs resulting from degenerative diseases or trauma has caused huge economic and health concerns around the world. Tissue engineering represents the only possibility to revert this scenario owing to its potential to regenerate or replace damaged tissues and organs. In a regeneration strategy, biomaterials play a key role promoting new tissue formation by providing adequate space for cell accommodation and appropriate biochemical and biophysical cues to support cell proliferation and differentiation. Among other physical cues, the architectural features of the biomaterial as a kind of instructive stimuli can influence cellular behaviors and guide cells towards a specific tissue organization. Thus, the optimization of biomaterial micro\/nano architecture, through different manufacturing techniques, is a crucial strategy for a successful regenerative therapy. Over the last decades, many micro\/nanostructured biomaterials have been developed to mimic the defined structure of ECM of various soft and hard tissues. This review intends to provide an overview of the relevant studies on micro\/nanostructured scaffolds created for soft and hard tissue regeneration and highlights their biological effects, with a particular focus on striated muscle, cartilage, and bone tissue engineering applications.<\/jats:p>","DOI":"10.3390\/mi13050780","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T21:36:06Z","timestamp":1652736966000},"page":"780","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["From Soft to Hard Biomimetic Materials: Tuning Micro\/Nano-Architecture of Scaffolds for Tissue Regeneration"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0142-6690","authenticated-orcid":false,"given":"Felicia","family":"Carotenuto","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Cliniche e Medicina Traslazionale, Universit\u00e0 Degli Studi di Roma \u201cTor Vergata\u201d, Via Montpellier 1, 00133 Rome, Italy"},{"name":"Department of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, CR Frascati, 00044 Rome, Italy"},{"name":"Centro di Ricerca Interdipartimentale di Medicina Rigenerativa (CIMER), Universit\u00e0 Degli Studi di Roma \u201cTor Vergata\u201d, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Politi","sequence":"additional","affiliation":[{"name":"Department of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, CR Frascati, 00044 Rome, Italy"},{"name":"Dipartimento di Scienze e Tecnologie Chimiche, Universit\u00e0 Degli Studi di Roma \u201cTor Vergata\u201d, Via della Ricerca Scientifica, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8013-1462","authenticated-orcid":false,"given":"Arsalan","family":"Ul Haq","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche e Medicina Traslazionale, Universit\u00e0 Degli Studi di Roma \u201cTor Vergata\u201d, Via Montpellier 1, 00133 Rome, Italy"},{"name":"Centro di Ricerca Interdipartimentale di Medicina Rigenerativa (CIMER), Universit\u00e0 Degli Studi di Roma \u201cTor Vergata\u201d, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-9754","authenticated-orcid":false,"given":"Fabio","family":"De Matteis","sequence":"additional","affiliation":[{"name":"Centro di Ricerca Interdipartimentale di Medicina Rigenerativa (CIMER), Universit\u00e0 Degli Studi di Roma \u201cTor Vergata\u201d, Via Montpellier 1, 00133 Rome, Italy"},{"name":"Dipartimento Ingegneria Industriale, Universit\u00e0 Degli Studi di Roma \u201cTor Vergata\u201d, Via del Politecnico, 00133 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Tamburri","sequence":"additional","affiliation":[{"name":"Centro di Ricerca Interdipartimentale di Medicina Rigenerativa (CIMER), Universit\u00e0 Degli Studi di Roma \u201cTor Vergata\u201d, Via Montpellier 1, 00133 Rome, Italy"},{"name":"Dipartimento di Scienze e Tecnologie Chimiche, Universit\u00e0 Degli Studi di Roma \u201cTor Vergata\u201d, Via della Ricerca Scientifica, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Terranova","sequence":"additional","affiliation":[{"name":"Centro di Ricerca Interdipartimentale di Medicina Rigenerativa (CIMER), Universit\u00e0 Degli Studi di Roma \u201cTor Vergata\u201d, Via Montpellier 1, 00133 Rome, Italy"},{"name":"Dipartimento di Scienze e Tecnologie Chimiche, Universit\u00e0 Degli Studi 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