{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:35:00Z","timestamp":1792805700171,"version":"4.5.0"},"reference-count":53,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Princes Nourah bint Abdulrahman University, Riyadh, Saudi Arabia","award":["PNURSP2022R33"],"award-info":[{"award-number":["PNURSP2022R33"]}],"id":[{"id":"https:\/\/ror.org\/05b0cyh02","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Nanotechnology is a new field that has gained considerable importance due to its potential uses in the field of biosciences, medicine, engineering, etc. In the present study, bio-inspired metallic iron nanoparticles (FeNPs) were prepared using biomass of Enterobacter train G52. The prepared particles were characterized by UV-spectroscopy, TGA, XRD, SEM, EDX, and FTIR techniques. The crystalline nature of the prepared FeNPs was confirmed by XRD. The SEM techniques revealed the particles size to be 23 nm, whereas in FTIR spectra the peaks in the functional group region indicated the involvement of bioactive compounds of selected bacterial strains in the capping of FeNPs. The EDX confirmed the presence of iron in the engineered FeNPs. The FeNPs were then evaluated for its antibacterial, antifungal, antioxidant, anti-inflammatory, anti-Alzheimer\u2019s, anti-larvicidal, protein kinase inhibition, anti-diabetic, and biocompatibility potentials using standard protocols. Substantial activities were observed in almost all biological assays used. The antioxidant, anti-cholinesterase, and anti-diabetic potential of the prepared nanoparticles were high in comparison to other areas of biological potential, indicating that the FeNPs are capable of targeting meditators of oxidative stress leading to diabetes and Alzheimer\u2019s disease. However, the claim made needs some further experimentation to confirm the observed potential in in vivo animal models.<\/jats:p>","DOI":"10.3390\/mi13081259","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T22:33:11Z","timestamp":1659997991000},"page":"1259","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Development of Iron Nanoparticles (FeNPs) Using Biomass of Enterobacter: Its Characterization, Antimicrobial, Anti-Alzheimer\u2019s, and Enzyme Inhibition Potential"],"prefix":"10.3390","volume":"13","author":[{"given":"Sania","family":"Zafar","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan 60000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-2622","authenticated-orcid":false,"given":"Shah","family":"Faisal","sequence":"additional","affiliation":[{"name":"Department of Life Science, National Tsing Hua University, Hsinchu City 30071, Taiwan"},{"name":"Department of Health and Biological Sciences, Abasyn University, Peshawar 25000, Pakistan"},{"name":"Institute of Biotechnology and Microbiology, Bacha Khan University, Charsadda 24460, KPK, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7225-2595","authenticated-orcid":false,"given":"Hasnain","family":"Jan","sequence":"additional","affiliation":[{"name":"Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-467X","authenticated-orcid":false,"given":"Riaz","family":"Ullah","sequence":"additional","affiliation":[{"name":"Medicinal Aromatic and Poisonous Plants Research Center, Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 12211, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Rizwan","sequence":"additional","affiliation":[{"name":"Center for Biotechnology and Microbiology, University of Swat, Odigram, Mingora 19130, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3549-5045","authenticated-orcid":false,"family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Abdul Wali Khan University, Mardan 23200, KPK, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9819-447X","authenticated-orcid":false,"given":"Amal","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Department of Basic Science, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Bibi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Shaheed Benazir University, Peshawar 25000, KPK, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin Ur","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Applied Physical and Material Sceinces, University of Swat, Odigram, Mingora 19130, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishma","family":"Khattak","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Shaheed Benazir University, Peshawar 00384, KPK, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2174\/1573394717666210715165127","article-title":"Oxidative Stress and Cellular Senescence: The Key Tumor-promoting Factors in Colon Cancer and Beneficial Effects of Polyphenols in Colon Cancer Prevention","volume":"17","author":"Bhatiya","year":"2021","journal-title":"Curr. 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