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However, the low-cost development of miniaturized gas sensors without compromising selectivity, sensitivity, and response time remains challenging. Microfluidics is a promising technology that has been exploited for decades to overcome such limitations, making it an excellent candidate for POU\/POC. However, microfluidic-based gas sensors remain a nascent field. In this review, the evolution of microfluidic gas sensors from basic electronic techniques to more advanced optical techniques such as surface-enhanced Raman spectroscopy to detect analytes is documented in detail. This paper focuses on the various detection methodologies used in microfluidic-based devices for detecting gases and airborne pathogens. Non-continuous microfluidic devices such as bubble\/droplet-based microfluidics technology that have been employed to detect gases and airborne pathogens are also discussed. The selectivity, sensitivity, advantages\/disadvantages vis-a-vis response time, and fabrication costs for all the microfluidic sensors are tabulated. The microfluidic sensors are grouped based on the target moiety, such as air pollutants such as carbon monoxide and nitrogen oxides, and airborne pathogens such as E. coli and SARS-CoV-2. The possible application scenarios for the various microfluidic devices are critically examined.<\/jats:p>","DOI":"10.3390\/mi13101716","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T02:10:27Z","timestamp":1665540627000},"page":"1716","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Microfluidic Gas Sensors: Detection Principle and Applications"],"prefix":"10.3390","volume":"13","author":[{"given":"Sreerag","family":"Kaaliveetil","sequence":"first","affiliation":[{"name":"Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saud","family":"Alssaidy","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenglong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan Haridas","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charmi","family":"Chande","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9767-9096","authenticated-orcid":false,"given":"Sagnik","family":"Basuray","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA"},{"name":"Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ali, S., Gupta, A., Shafiei, M., and Langford, S.J. (2021). Recent Advances in Perylene Diimide-Based Active Materials in Electrical Mode Gas Sensing. Chemosensors, 9.","DOI":"10.3390\/chemosensors9020030"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/apt.12657","article-title":"Review article: Next generation diagnostic modalities in gastroenterology\u2013gas phase volatile compound biomarker detection","volume":"39","author":"Arasaradnam","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1900688","DOI":"10.1002\/smtd.201900688","article-title":"Application of Microfluidics in Wearable Devices","volume":"3","author":"Chen","year":"2019","journal-title":"Small Methods"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.snb.2011.01.011","article-title":"Microfluidic gas sensor with integrated pumping system","volume":"170","author":"Martini","year":"2012","journal-title":"Sens. Actuators B Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"30011","DOI":"10.3390\/s151229783","article-title":"Microfluidics Integrated Biosensors: A Leading Technology towards Lab-on-a-Chip and Sensing Applications","volume":"15","author":"Luka","year":"2015","journal-title":"Sensors"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0924-4247(99)00060-6","article-title":"Microfluidic system for the integration and cyclic operation of gas sensors","volume":"76","author":"Meckes","year":"1999","journal-title":"Sens. Actuators A Phys."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Paknahad, M., Ghafarinia, V., and Hossein-Babaei, F. (2012, January 7\u20139). A microfluidic gas analyzer for selective detection of biomarker gases. Proceedings of the 2012 IEEE Sensors Applications Symposium Proceedings, Brescia, Italy.","DOI":"10.1109\/SAS.2012.6166309"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bios.2015.04.033","article-title":"Bioelectronic nose combined with a microfluidic system for the detection of gaseous trimethylamine","volume":"71","author":"Lee","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1021\/es1043547","article-title":"Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols","volume":"45","author":"Shen","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.snb.2016.10.048","article-title":"Characterization of channel coating and dimensions of microfluidic-based gas detectors","volume":"241","author":"Paknahad","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"42299","DOI":"10.1038\/srep42299","article-title":"The selective flow of volatile organic compounds in conductive polymer-coated microchannels","volume":"7","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/s41598-018-36615-6","article-title":"Selective detection of volatile organic compounds in microfluidic gas detectors based on \u201clike dissolves like\u201d","volume":"9","author":"Paknahad","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1039\/C5LC00328H","article-title":"Flow-through microfluidic photoionization detectors for rapid and highly sensitive vapor detection","volume":"15","author":"Zhu","year":"2015","journal-title":"Lab. Chip."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1021\/ac400590c","article-title":"Microfluidic Device for Efficient Airborne Bacteria Capture and Enrichment","volume":"85","author":"Jing","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1021\/acsami.9b19358","article-title":"Array-Assisted SERS Microfluidic Chips for Highly Sensitive and Multiplex Gas Sensing","volume":"12","author":"Yang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"127566","DOI":"10.1016\/j.jhazmat.2021.127566","article-title":"Selective detection of VOCs using microfluidic gas sensor with embedded cylindrical microfeatures coated with graphene oxide","volume":"424","author":"Ghazi","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1002\/elps.200700552","article-title":"Fabrication, modification, and application of poly(methyl methacrylate) microfluidic chips","volume":"29","author":"Chen","year":"2008","journal-title":"Electrophoresis"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1109\/JSEN.2011.2174218","article-title":"A Microfluidic-Colorimetric Sensor for Continuous Monitoring of Reactive Environmental Chemicals","volume":"12","author":"Wang","year":"2012","journal-title":"IEEE Sens. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.aca.2018.07.053","article-title":"Multiplex quantification of metals in airborne particulate matter via smartphone and paper-based microfluidics","volume":"1044","author":"Sun","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"013003","DOI":"10.1063\/10.0003447","article-title":"A combined virtual impactor and field-effect transistor microsystem for particulate matter separation and detection","volume":"4","author":"Li","year":"2021","journal-title":"Nanotechnol. Precis. Eng."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bios.2019.01.013","article-title":"Integration of a field effect transistor-based aptasensor under a hydrophobic membrane for bioelectronic nose applications","volume":"129","author":"Kuznetsov","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1021\/ac100085w","article-title":"Patterned Electrode-Based Amperometric Gas Sensor for Direct Nitric Oxide Detection within Microfluidic Devices","volume":"82","author":"Cha","year":"2010","journal-title":"Anal. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.aca.2019.04.042","article-title":"Fast responding hydrogen gas sensors using platinum nanoparticle modified microchannels and ionic liquids","volume":"1072","author":"Hussain","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Guo, X.-L., Chen, Y., Jiang, H.-L., Qiu, X.-B., and Yu, D.-L. (2018). Smartphone-Based Microfluidic Colorimetric Sensor for Gaseous Formaldehyde Determination with High Sensitivity and Selectivity. Sensors, 18.","DOI":"10.3390\/s18093141"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"15983","DOI":"10.1038\/srep15983","article-title":"Integrated micro-optofluidic platform for real-time detection of airborne microorganisms","volume":"5","author":"Choi","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"113912","DOI":"10.1016\/j.bios.2021.113912","article-title":"Direct capture and smartphone quantification of airborne SARS-CoV-2 on a paper microfluidic chip","volume":"200","author":"Kim","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1021\/acs.analchem.0c05154","article-title":"Efficient Microfluidic-Based Air Sampling\/Monitoring Platform for Detection of Aerosol SARS-CoV-2 On-site","volume":"93","author":"Xiong","year":"2021","journal-title":"Anal. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1021\/acssensors.6b00282","article-title":"High-Throughput Microfluidic Device for LAMP Analysis of Airborne Bacteria","volume":"1","author":"Jiang","year":"2016","journal-title":"ACS Sens."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"18898","DOI":"10.1073\/pnas.0708596104","article-title":"Free-surface microfluidic control of surface-enhanced Raman spectroscopy for the optimized detection of airborne molecules","volume":"104","author":"Piorek","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9700","DOI":"10.1021\/ac302497y","article-title":"Free-Surface Microfluidics\/Surface-Enhanced Raman Spectroscopy for Real-Time Trace Vapor Detection of Explosives","volume":"84","author":"Piorek","year":"2012","journal-title":"Anal. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"39584","DOI":"10.1021\/acsami.7b11649","article-title":"Direct Metal Writing and Precise Positioning of Gold Nanoparticles within Microfluidic Channels for SERS Sensing of Gaseous Analytes","volume":"9","author":"Lee","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Lafuente, M., Almaz\u00e1n, F., Bernad, E., Urbiztondo, M.A., Santamar\u00eda, J., Mallada, R., and Pina, M.P. (2019, January 23\u201327). SERS Detection of Neurotoxic Agents in Gas Phase Using Microfluidic Chips Containing Gold-Mesoporous Silica as Plasmonic-Sorbent. Proceedings of the 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (Transducers & Eurosensors XXXIII), Berlin, Germany.","DOI":"10.1109\/TRANSDUCERS.2019.8808289"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"12996","DOI":"10.1021\/acsnano.1c01890","article-title":"Ti3C2Tx MXene-Loaded 3D Substrate toward On-Chip Multi-Gas Sensing with Surface-Enhanced Raman Spectroscopy (SERS) Barcode Readout","volume":"15","author":"Yang","year":"2021","journal-title":"ACS Nano"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"B3078","DOI":"10.1149\/2.0121808jes","article-title":"Polymer Composite Optically Integrated Lab on Chip for the Detection of Ammonia","volume":"165","author":"Ozhikandathil","year":"2018","journal-title":"J. Electrochem. Soc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1039\/C4LC00892H","article-title":"A bubble-based microfluidic gas sensor for gas chromatographs","volume":"15","author":"Bulbul","year":"2015","journal-title":"Lab A Chip"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1080\/02786826.2016.1275515","article-title":"Droplet-based microfluidics detector for bioaerosol detection","volume":"51","author":"Damit","year":"2017","journal-title":"Aerosol Sci. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.snb.2018.03.057","article-title":"An integrated gas-liquid droplet microfluidic platform for digital sampling and detection of airborne targets","volume":"267","author":"Tirandazi","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Huang, S., Connolly, J., Khlystov, A., and Fair, R.B. (2020). Digital Microfluidics for the Detection of Selected Inorganic Ions in Aerosols. Sensors, 20.","DOI":"10.3390\/s20051281"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.1538-7305.1953.tb01420.x","article-title":"Surface properties of germanium","volume":"32","author":"Brattain","year":"1953","journal-title":"Bell Syst. Tech. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.snb.2018.08.129","article-title":"An overview: Facet-dependent metal oxide semiconductor gas sensors","volume":"277","author":"Gao","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Rebord\u00e3o, G., Palma, S.I.C.J., and Roque, A.C.A. (2022, July 15). Sensors|Free Full-Text|Microfluidics in Gas Sensing and Artificial Olfaction|HTML. Available online: https:\/\/www.mdpi.com\/1424-8220\/20\/20\/5742\/htm.","DOI":"10.3390\/s20205742"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"10173","DOI":"10.1021\/acsami.7b18140","article-title":"Finely Tuned SnO 2 Nanoparticles for Efficient Detection of Reducing and Oxidizing Gases: The Influence of Alkali Metal Cation on Gas-Sensing Properties","volume":"10","author":"Lee","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1039\/D1TC00544H","article-title":"Designing chemically selective liquid crystalline materials that respond to oxidizing gases","volume":"9","author":"Bao","year":"2021","journal-title":"J. Mater. Chem. C"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"338575","DOI":"10.1016\/j.aca.2021.338575","article-title":"Highly sensitive gas sensing platforms based on field effect Transistor-A review","volume":"1172","author":"Zhang","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7111","DOI":"10.3390\/s90907111","article-title":"Ion-Sensitive Field-Effect Transistor for Biological Sensing","volume":"9","author":"Lee","year":"2009","journal-title":"Sensors"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/10408398.2018.1518897","article-title":"Loop-mediated isothermal amplification-based microfluidic chip for pathogen detection","volume":"60","author":"Shang","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"112940","DOI":"10.1016\/j.bios.2020.112940","article-title":"Electrochemical impedimetric biosensors, featuring the use of Room Temperature Ionic Liquids (RTILs): Special focus on non-faradaic sensing","volume":"177","author":"Upasham","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"58371","DOI":"10.1039\/C5RA06754E","article-title":"Methods and approach of utilizing ionic liquids as gas sensing materials","volume":"5","author":"Rehman","year":"2015","journal-title":"RSC Adv."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"113163","DOI":"10.1016\/j.bios.2021.113163","article-title":"ESSENCE\u2013A rapid, shear-enhanced, flow-through, capacitive electrochemical platform for rapid detection of biomolecules | Elsevier Enhanced Reader","volume":"182","author":"Cheng","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"10503","DOI":"10.1021\/acsami.9b22445","article-title":"Metal\u2013Organic Framework-Based Microfluidic Impedance Sensor Platform for Ultrasensitive Detection of Perfluorooctanesulfonate","volume":"12","author":"Cheng","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.anchem.1.031207.112814","article-title":"Surface-Enhanced Raman Spectroscopy","volume":"1","author":"Stiles","year":"2008","journal-title":"Annu. Rev. Anal. Chem. Palo Alto Calif."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1103\/PhysRevLett.78.1667","article-title":"Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)","volume":"78","author":"Kneipp","year":"1997","journal-title":"Phys. Rev. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1126\/science.275.5303.1102","article-title":"Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering","volume":"275","author":"Nie","year":"1997","journal-title":"Science"},{"key":"ref_54","first-page":"85","article-title":"Chapter Eight\u2013Reverse Transcription-Loop-Mediated Isothermal Amplification System for the Detection of Rabies Virus","volume":"Volume 1","author":"Rupprecht","year":"2014","journal-title":"Current Laboratory Techniques in Rabies Diagnosis, Research and Prevention"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1017\/S1466252315000018","article-title":"Loop-mediated isothermal amplification for diagnosis of 18 World Organization for Animal Health (OIE) notifiable viral diseases of ruminants, swine and poultry","volume":"16","author":"Mansour","year":"2015","journal-title":"Anim. Health Res. Rev."},{"key":"ref_56","first-page":"496","article-title":"SYTO probes in the cytometry of tumor cell death\u2013Wlodkowic\u20132008\u2013Cytometry Part A\u2013Wiley Online Library","volume":"73A","author":"Wlodkowic","year":"2008","journal-title":"J. Quant. Cell Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1021\/acssensors.7b00873","article-title":"Target Confinement in Small Reaction Volumes Using Microfluidic Technologies: A Smart Approach for Single-Entity Detection and Analysis","volume":"3","author":"Ven","year":"2018","journal-title":"ACS Sens."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"120688","DOI":"10.1016\/j.apcatb.2021.120688","article-title":"Selective photocatalytic oxidation of gaseous ammonia at ppb level over Pt and F modified TiO2","volume":"300","author":"Shu","year":"2022","journal-title":"Appl. Catal. B Environ."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.envint.2014.10.005","article-title":"A review on the human health impact of airborne particulate matter","volume":"74","author":"Kim","year":"2015","journal-title":"Environ. Int."},{"key":"ref_60","unstructured":"(2022, August 21). WHO Coronavirus (COVID-19) Dashboard. Available online: https:\/\/covid19.who.int."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1023\/A:1014215728074","article-title":"An Evaporation-Based Disposable Micropump Concept for Continuous Monitoring Applications","volume":"4","author":"Effenhauser","year":"2002","journal-title":"Biomed. Microdevices"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"213514","DOI":"10.1016\/j.ccr.2020.213514","article-title":"State of the art recent progress in two dimensional MXenes based gas sensors and biosensors: A comprehensive review","volume":"424","author":"Deshmukh","year":"2020","journal-title":"Coord. Chem. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"130972","DOI":"10.1016\/j.snb.2021.130972","article-title":"Nanoporous naphthalene diimide surface enhances humidity and ammonia sensing at room temperature","volume":"351","author":"Ali","year":"2022","journal-title":"Sens. Actuators B Chem."}],"container-title":["Micromachines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-666X\/13\/10\/1716\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:50:00Z","timestamp":1760143800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-666X\/13\/10\/1716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,11]]},"references-count":63,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["mi13101716"],"URL":"https:\/\/doi.org\/10.3390\/mi13101716","relation":{},"ISSN":["2072-666X"],"issn-type":[{"value":"2072-666X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,11]]}}}