{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:31:03Z","timestamp":1784914263613,"version":"3.55.0"},"reference-count":49,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONICET","award":["PIP 2015"],"award-info":[{"award-number":["PIP 2015"]}]},{"name":"CONICET","award":["PICT 2019-04111"],"award-info":[{"award-number":["PICT 2019-04111"]}]},{"name":"CONICET","award":["1200828"],"award-info":[{"award-number":["1200828"]}]},{"name":"SECyT-UNC","award":["PIP 2015"],"award-info":[{"award-number":["PIP 2015"]}]},{"name":"SECyT-UNC","award":["PICT 2019-04111"],"award-info":[{"award-number":["PICT 2019-04111"]}]},{"name":"SECyT-UNC","award":["1200828"],"award-info":[{"award-number":["1200828"]}]},{"DOI":"10.13039\/501100003074","name":"ANPCyT","doi-asserted-by":"publisher","award":["PIP 2015"],"award-info":[{"award-number":["PIP 2015"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"ANPCyT","doi-asserted-by":"publisher","award":["PICT 2019-04111"],"award-info":[{"award-number":["PICT 2019-04111"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"ANPCyT","doi-asserted-by":"publisher","award":["1200828"],"award-info":[{"award-number":["1200828"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ANID-FONDECYT","award":["PIP 2015"],"award-info":[{"award-number":["PIP 2015"]}]},{"name":"ANID-FONDECYT","award":["PICT 2019-04111"],"award-info":[{"award-number":["PICT 2019-04111"]}]},{"name":"ANID-FONDECYT","award":["1200828"],"award-info":[{"award-number":["1200828"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>We report the advantages of glassy carbon electrodes (GCE) modified with multi-walled carbon nanotubes (MWCNTs) non-covalently functionalized with polyarginine (PolyArg) for the adsorption and electrooxidation of different DNAs and the analytical applications of the resulting platform. The presence of the carbon nanostructures, and mainly the charge of the PolyArg that supports them, facilitates the adsorption of calf-thymus and salmon sperm double-stranded DNAs and produces an important decrease in the overvoltages for the oxidation of guanine and adenine residues and a significant enhancement in the associated currents. As a proof-of-concept of possible GCE\/MWCNTs-PolyArg biosensing applications, we develop an impedimetric genosensor for the quantification of microRNA-21 at femtomolar levels, using GCE\/MWCNTs-PolyArg as a platform for immobilizing the DNA probe, with a detection limit of 3fM, a sensitivity of 1.544 \u00d7 103 \u03a9 M\u22121, and a successful application in enriched biological fluids.<\/jats:p>","DOI":"10.3390\/mi13111978","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T02:31:27Z","timestamp":1668565887000},"page":"1978","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genosensing Applications of Glassy Carbon Electrodes Modified with Multi-Walled Carbon Nanotubes Non-Covalently Functionalized with Polyarginine"],"prefix":"10.3390","volume":"13","author":[{"given":"Pablo","family":"Gallay","sequence":"first","affiliation":[{"name":"INFIQC, Departamento de FIsicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Ciudad Universitaria, C\u00f3rdoba 5000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"L\u00f3pez Mujica","sequence":"additional","affiliation":[{"name":"INFIQC, Departamento de FIsicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Ciudad Universitaria, C\u00f3rdoba 5000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0868-4294","authenticated-orcid":false,"given":"Soledad","family":"Bollo","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n de Procesos Redox, CIPRex, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Sergio Livingstone 1007, Independencia, Santiago 8380000, Chile"},{"name":"Departamento de Qu\u00edmica Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Sergio Livingstone 1007, Independencia, Santiago 8380000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Rivas","sequence":"additional","affiliation":[{"name":"INFIQC, Departamento de FIsicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Ciudad Universitaria, C\u00f3rdoba 5000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"131944","DOI":"10.1016\/j.snb.2022.131944","article-title":"Comprehensive review on the electrochemical biosensors of different breast cancer biomarkers","volume":"365","author":"Mostafa","year":"2022","journal-title":"Sens. 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