{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:54:05Z","timestamp":1760244845676,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Two structures (Ag\/ZnO\/ITI\/glass: #1 sample and Ag\/ZnO\/SiO2\/Si: #2 sample) are investigated, on the one hand, from the point of view of the formation of evanescent waves in the gratings of metal strips on the structures when the incident TEz wave in the radio frequency range is used. The simulation of the formation of evanescent waves at the edge of the Ag strips, with thicknesses in the range of micrometers, was carried out before the test in the subwavelength regime, with the help of a new improved transducer with metamaterial (MM) lenses. By simulation, a field snapshot was obtained in each sequence of geometry. The evanescent waves are emphasized in the plane XY, due to the scattering of the field on the edge of the strips. On the other hand, ZnO nanoparticles are investigated as a convenient high-efficiency biodetection material, where these structures were used as a biosensitive element to various enzymes (glucose, cholesterol, uric acid, and ascorbic acid). The obtained results demonstrate that the investigated structures based on ZnO nanostructures deposited on different supports are fast and sensitive for enzyme detection and can be successfully incorporated into a device as a biosensing element.<\/jats:p>","DOI":"10.3390\/mi13111997","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T03:35:23Z","timestamp":1668742523000},"page":"1997","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metallic Structures Based on Zinc Oxide Film for Enzyme Biorecognition"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9614-0101","authenticated-orcid":false,"given":"Nicoleta","family":"Iftimie","sequence":"first","affiliation":[{"name":"NDT Department, National Institute of Research and Development for Technical Physics, 700050 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1618-7650","authenticated-orcid":false,"given":"Rozina","family":"Steigmann","sequence":"additional","affiliation":[{"name":"NDT Department, National Institute of Research and Development for Technical Physics, 700050 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Faktorova","sequence":"additional","affiliation":[{"name":"Department of Design and Special Technology, Faculty of Special Technology, Tren\u010d\u00edn University of Alexander Dub\u010dek in Tren\u010d\u00edn, 911 01 Tren\u010d\u00edn, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9863-3110","authenticated-orcid":false,"given":"Adriana","family":"Savin","sequence":"additional","affiliation":[{"name":"NDT Department, National Institute of Research and Development for Technical Physics, 700050 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1039\/c3cs35528d","article-title":"Biosensors: Sense and sensibility","volume":"42","author":"Turner","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.rbmret.2007.11.007","article-title":"Amperometric enzyme biosensors: Past, present and future","volume":"29","author":"Dzyadevych","year":"2008","journal-title":"IRBM"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3390\/s100201216","article-title":"ZnO-based amperometric enzyme biosensors","volume":"10","author":"Zhao","year":"2010","journal-title":"Sensors"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1039\/c2cs35475f","article-title":"Enzyme nanoarchitectonics: Organization and device application","volume":"42","author":"Ariga","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1007\/s10439-011-0457-4","article-title":"Nanomaterial-based biosensor as an emerging tool for biomedical applications","volume":"40","author":"Lee","year":"2012","journal-title":"Ann. Biomed. Eng."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.bios.2013.06.038","article-title":"rhEPO\/EPO discrimination with ultrasensitive electrochemical biosensor based on sandwich-typenano-Au\/ZnOsol\u2013gel\/nano-Au signal amplification","volume":"50","author":"Zhang","year":"2013","journal-title":"Biosensensors Bioelectron."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1007\/s10853-012-6648-z","article-title":"Effect of in incorporation on the structural, electrical, and gas sensing properties of ZnO films","volume":"47","author":"Rambu","year":"2012","journal-title":"J. Mater. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.mseb.2011.10.015","article-title":"Influence of the substrate nature on the properties of ZnO thin films","volume":"177","author":"Rambu","year":"2012","journal-title":"Mater. Sci. Eng. B"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.tsf.2011.04.158","article-title":"Polycrystalline ZnO\u2013In2O3 thin films as gas sensors","volume":"520","author":"Rambu","year":"2011","journal-title":"Thin Solid Film."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4028\/www.scientific.net\/AMM.772.62","article-title":"Characterization of the Thin Films Structures in Subwavelength Regime as Biosensing Materials","volume":"772","author":"Steigmann","year":"2015","journal-title":"Appl. Mech. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.biotechadv.2011.09.003","article-title":"Immobilization strategies to develop Enzymatic biosensors","volume":"30","author":"Sassolas","year":"2012","journal-title":"Biotechnol. Adv."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.snb.2008.10.072","article-title":"ZnO nanoparticles or ZnO films: A comparison of the gas sensing capabilities","volume":"137","author":"Eriksson","year":"2009","journal-title":"Sens. Actuators B"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"233106","DOI":"10.1063\/1.2210078","article-title":"Zinc oxide nanocomb biosensor for glucose detection","volume":"88","author":"Wang","year":"2006","journal-title":"Appl. Phys. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1103\/PhysRevLett.76.4773","article-title":"Extremely Low Frequency Plasmons in Metallic Mesostructures","volume":"76","author":"Pendry","year":"1996","journal-title":"Phys. Rev. Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.mseb.2013.03.022","article-title":"Electromagnetic metamaterials","volume":"178","author":"Grimberg","year":"2013","journal-title":"Mater. Sci. Eng. B"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1784\/insi.2011.53.3.132","article-title":"Electromagnetic non-destructive evaluation using metamaterials","volume":"53","author":"Grimberg","year":"2011","journal-title":"Insight"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1109\/22.798002","article-title":"Magnetism from conductors and enhanced nonlinear phenomena","volume":"47","author":"Pendry","year":"1999","journal-title":"IEEE Trans. Microw. Theory Tech."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1103\/PhysRevLett.85.3966","article-title":"Negative refraction makes a perfect lens","volume":"85","author":"Pendry","year":"2000","journal-title":"Phys. Rev. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1109\/22.798001","article-title":"High-impedance electromagnetic surfaces with a forbidden frequency band","volume":"47","author":"Sievenpiper","year":"1999","journal-title":"IEEE Trans. Microw. Theory Tech."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1126\/science.1125907","article-title":"Controlling electromagnetic fields","volume":"312","author":"Pendry","year":"2006","journal-title":"Science"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"11786","DOI":"10.3390\/s140711786","article-title":"Metallic Strip Gratings in the Sub-Subwavelength Regime","volume":"14","author":"Savin","year":"2014","journal-title":"Sensors"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nmat2546","article-title":"Plasmonic nanorod metamaterials for biosensing","volume":"8","author":"Kabashin","year":"2009","journal-title":"Nat. Mater."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.tsf.2010.08.005","article-title":"Thickness dependency of sol-gel derived ZnO thin films on gas sensing behaviors","volume":"519","author":"Kakati","year":"2010","journal-title":"Thin Solid Film."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.apsusc.2007.07.082","article-title":"Ultraviolet emission properties of ZnO film with zinc deficiency by SS CVD","volume":"254","author":"Dai","year":"2008","journal-title":"J. Appl. Surf. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1016\/j.apsusc.2007.10.105","article-title":"Structural and optical properties of sputtered ZnO thin films","volume":"254","author":"Flickyngerova","year":"2007","journal-title":"Appl. Surf. Sci."},{"key":"ref_26","first-page":"3486","article-title":"The evanescent waves in metallic strip gratings and complex structures in subwavelength regime","volume":"2","author":"Iftimie","year":"2015","journal-title":"Mater. Today Proc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3762\/bjnano.6.100","article-title":"Characterization of nanostructured ZnO thin films deposited through vacuum evaporation","volume":"6","author":"Alvarado","year":"2015","journal-title":"Beilstein J. Nanotechnol."},{"key":"ref_28","first-page":"100","article-title":"Experimental Characterization of ZnO Thins Films and Identification of Frequency Peaks in ZnO\/SiO2\/Si SAW Devices","volume":"3","author":"Bensmaine","year":"2013","journal-title":"Am. J. Mater. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.phpro.2014.07.021","article-title":"Effect of the temperature on ZnO thin films deposited by r.f. magnetron","volume":"55","author":"Bensmaine","year":"2014","journal-title":"Phys. Procedia"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"339851","DOI":"10.1016\/j.aca.2022.339851","article-title":"Lactate biosensing based on covalent immobilization of lactate oxidase onto chevron-like5etamate nanoribbons via diazotization-coupling reaction","volume":"1208","author":"Sainz","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"087006","DOI":"10.1117\/1.JBO.21.8.087006","article-title":"Table top surface plasmon resonance measurement system for efficient urea biosensing using ZnO thin film matrix","volume":"21","author":"Paliwal","year":"2016","journal-title":"J. Biomed. Opt."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"114701","DOI":"10.1063\/1.4768450","article-title":"Al:ZnO thin film: An efficient matrix for cholesterol detection","volume":"112","author":"Tomar","year":"2012","journal-title":"J. Appl. Phys."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Malhotra, B.D., and Ali, M.A. (2018). Nanomaterials in Biosensors: Fundamentals and Applications. Nanomater. Biosens., 1\u201374.","DOI":"10.1016\/B978-0-323-44923-6.00001-7"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.3390\/s100504855","article-title":"A Comprehensive Review of Glucose Biosensors Based on Nanostructured Metal Oxides-Review","volume":"10","author":"Rahman","year":"2010","journal-title":"Sensors"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/j.bios.2008.09.026","article-title":"Recent advances in material science for developing enzyme electrodes-Review","volume":"24","author":"Sarma","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"15903","DOI":"10.3390\/s150715903","article-title":"An electromagnetic sensors with a metamaterial lens for nondestructive evaluation of composite materials","volume":"15","author":"Savin","year":"2015","journal-title":"Sensors"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1098\/rspa.2011.0666","article-title":"High Frequency Electromagnetic Non-destructive Evaluation for High Spatial Resolution using Metamaterial","volume":"468","author":"Grimberg","year":"2012","journal-title":"Proc. R. Soc. A"},{"key":"ref_38","unstructured":"Savin, A., and Steigmann, R. (2014). Electromagnetic Transducer for Assessing Integrity of Braids of Single-Layer Printed Wiring on Flexible Support and of Layered Meso-Structures. (Patent RO129801-A0)."},{"key":"ref_39","unstructured":"Born, M., and Wolf, E. (1975). Principle of Optics, Pergamon Press. [5th ed.]."},{"key":"ref_40","unstructured":"(2022, November 13). REMCOM. Available online: https:\/\/www.remcom.com\/electromagnetic-applications."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1109\/74.414731","article-title":"A selective survey of the finite-difference time-domain literature","volume":"37","author":"Shlager","year":"1995","journal-title":"IEEE Antennas Propagat. Mag."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1063\/1.3206091","article-title":"Fifty years of Anderson localization","volume":"62","author":"Lagendijk","year":"1991","journal-title":"Physics Today"},{"key":"ref_43","unstructured":"Grimberg, R., and Savin, A. (2011). Electromagnetic Transducer for Evaluation of Structure and Integrity of the Composite Materials with Polymer Matrix Reinforced with Carbon Fibers. (Patent RO126245-A0)."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Peterson, A.F., Ray, S.L., and Mittra, R. (1998). Computational Methods for Electromagnetics, Institute of Electrical and Electronics Engineers 2: IEEE Press.","DOI":"10.1109\/9780470544303"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1126\/science.1096796","article-title":"Metamaterials and Negative Refractive Index","volume":"305","author":"Smith","year":"2004","journal-title":"Science"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"064904","DOI":"10.1063\/1.3633212","article-title":"Influence of surface defects in ZnO thin films on its biosensing response characteristic","volume":"110","author":"Saha","year":"2011","journal-title":"J. Appl. Phys."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3390\/bios2030269","article-title":"Electrochemical based biosensors","volume":"2","author":"Liu","year":"2012","journal-title":"Biosensors"}],"container-title":["Micromachines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-666X\/13\/11\/1997\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:20:04Z","timestamp":1760145604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-666X\/13\/11\/1997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,17]]},"references-count":47,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["mi13111997"],"URL":"https:\/\/doi.org\/10.3390\/mi13111997","relation":{},"ISSN":["2072-666X"],"issn-type":[{"type":"electronic","value":"2072-666X"}],"subject":[],"published":{"date-parts":[[2022,11,17]]}}}