{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:38:15Z","timestamp":1789663095142,"version":"4.0.1"},"reference-count":40,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["P30EY001583"],"award-info":[{"award-number":["P30EY001583"]}]},{"name":"NIH","award":["R01-EY025752"],"award-info":[{"award-number":["R01-EY025752"]}]},{"name":"NIH","award":["R01-EY032478"],"award-info":[{"award-number":["R01-EY032478"]}]},{"name":"University of Pennsylvania Research Foundation","award":["P30EY001583"],"award-info":[{"award-number":["P30EY001583"]}]},{"name":"University of Pennsylvania Research Foundation","award":["R01-EY025752"],"award-info":[{"award-number":["R01-EY025752"]}]},{"name":"University of Pennsylvania Research Foundation","award":["R01-EY032478"],"award-info":[{"award-number":["R01-EY032478"]}]},{"name":"Michigan State University Start-up Funds","award":["P30EY001583"],"award-info":[{"award-number":["P30EY001583"]}]},{"name":"Michigan State University Start-up Funds","award":["R01-EY025752"],"award-info":[{"award-number":["R01-EY025752"]}]},{"name":"Michigan State University Start-up Funds","award":["R01-EY032478"],"award-info":[{"award-number":["R01-EY032478"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Background: Inherited primary open-angle glaucoma (POAG) in Beagle dogs is a well-established large animal model of glaucoma and is caused by a G661R missense mutation in the ADAMTS10 gene. Using this model, the study describes early clinical disease markers for canine glaucoma. Methods: Spectral-domain optical coherence tomography (SD-OCT) was used to assess nine adult, ADAMTS10-mutant (median age 45.6 months, range 28.8\u201352.8 months; mean diurnal intraocular pressure (IOP): 29.9 +\/\u2212 SEM 0.44 mmHg) and three related age-matched control Beagles (mean diurnal IOP: 18.0 +\/\u2212 SEM 0.53 mmHg). Results: Of all the optic nerve head (ONH) parameters evaluated, the loss of myelin peak height in the horizontal plane was most significant (from 154 +\/\u2212 SEM 38.4 \u03bcm to 9.3 +\/\u2212 SEM 22.1 \u03bcm; p &lt; 0.01). There was a strong significant negative correlation between myelin peak height and IOP (Spearman correlation: \u22120.78; p &lt; 0.003). There were no significant differences in the thickness of any retinal layers evaluated. Conclusions: SD-OCT is a useful tool to detect early glaucomatous damage to the ONH in dogs before vision loss. Loss in myelin peak height without inner retinal thinning was identified as an early clinical disease marker. This suggests that initial degenerative changes are mostly due to the loss of myelin.<\/jats:p>","DOI":"10.3390\/mi15060780","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T08:52:10Z","timestamp":1718355130000},"page":"780","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of Early Glaucomatous Optic Neuropathy in the Dog by Spectral Domain Optical Coherence Tomography (SD-OCT)"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4700-7491","authenticated-orcid":false,"given":"Annie","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine D.","family":"Harman","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"Koehl","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9960-678X","authenticated-orcid":false,"given":"Leandro B. C.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence M.","family":"Occelli","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Storey","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Shuang","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-0588","authenticated-orcid":false,"given":"Andr\u00e1s M.","family":"Kom\u00e1romy","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1463-5224.2004.04006.x","article-title":"Prevalence of the breed-related glaucomas in pure-bred dogs in North America","volume":"7","author":"Gelatt","year":"2004","journal-title":"Vet. 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