{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:54:11Z","timestamp":1780520051797,"version":"3.54.1"},"reference-count":47,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>This study aimed to evaluate whether clear corneal incisions (CCIs) created with the FEMTO LDV Z8 femtosecond laser during cataract surgery are non-inferior to manual CCIs in terms of surgically induced astigmatism (SIA) and higher-order aberrations (HOAs). A total of 78 cataract patients were randomly assigned to two groups: 38 eyes underwent femtosecond laser-assisted cataract surgery (FLACS), and 40 eyes underwent conventional manual cataract surgery (CCS). Preoperative and six-week postoperative SIA, HOAs, and all topographic and refractive data were analysed for both groups. FLACS-generated CCIs demonstrated equivalence to manual CCIs. The mean SIA was 0.44 \u00b1 0.27 dioptres (D) in the FLACS group and 0.58 \u00b1 0.46 D in the CCS group (p = 0.18), with lower variability in the FLACS group. The root mean square (RMS) corneal HOA at six weeks was 0.69 \u00b1 0.17 \u00b5m in the FLACS group and 0.80 \u00b1 0.56 \u00b5m in the CCS group (p &gt; 0.05). These results confirm the efficacy, reproducibility, and safety of FLACS. Although not statistically significant, FLACS induced numerically lower SIA values and less variability than manual CCIs. Both groups were comparable in terms of HOAs, though higher mean values and variability were observed in the CCS group.<\/jats:p>","DOI":"10.3390\/mi16080939","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T16:09:55Z","timestamp":1755274195000},"page":"939","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Clear Corneal Incisions via Femtosecond Laser Versus Manual Incisions on Corneal Aberrations in Cataract Surgery"],"prefix":"10.3390","volume":"16","author":[{"given":"Vesko","family":"Onov","sequence":"first","affiliation":[{"name":"Eye Clinic ORASIS, Swiss Eye Research Foundation, 5734 Reinach, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Thumann","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, Department of Clinical Neurosciences, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Experimental Ophthalmology, University of Geneva, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6861-5851","authenticated-orcid":false,"given":"Martina","family":"Kropp","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, Department of Clinical Neurosciences, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Experimental Ophthalmology, University of Geneva, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-4899","authenticated-orcid":false,"given":"Zeljka","family":"Cvejic","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Slezak","sequence":"additional","affiliation":[{"name":"Eye Clinic ORASIS, Swiss Eye Research Foundation, 5734 Reinach, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1987-6232","authenticated-orcid":false,"given":"Bojan","family":"Pajic","sequence":"additional","affiliation":[{"name":"Eye Clinic ORASIS, Swiss Eye Research Foundation, 5734 Reinach, Switzerland"},{"name":"Division of Ophthalmology, Department of Clinical Neurosciences, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Experimental Ophthalmology, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Department of Physics, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine of the Military Medical Academy, University of Defense, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3928\/1081597X-20091117-04","article-title":"Initial clinical evaluation of an intraocular femtosecond laser in cataract surgery","volume":"25","author":"Nagy","year":"2009","journal-title":"J. Refract. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/ICU.0b013e3283414f76","article-title":"Femtosecond laser-assisted cataract surgery","volume":"22","author":"He","year":"2011","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ajo.2008.08.026","article-title":"Femtosecond lasers in ophthalmology","volume":"147","author":"Soong","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Pajic, B., Cvejic, Z., and Pajic-Eggspuehler, B. (2017). Cataract Surgery Performed by High Frequency LDV Z8 Femtosecond Laser: Safety, Efficacy, and Its Physical Properties. Sensors, 17.","DOI":"10.3390\/s17061429"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Schroeter, A., Kropp, M., Cvejic, Z., Thumann, G., and Pajic, B. (2021). Comparison of femtosecond laser-assisted and ultrasound-assisted cataract surgery with focus on endothelial analysis. Sensors, 21.","DOI":"10.3390\/s21030996"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jcrs.2013.08.045","article-title":"Initial evaluation of a femtosecond laser system in cataract surgery","volume":"40","author":"Chang","year":"2014","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.jcrs.2010.03.027","article-title":"Femtosecond laser-assisted cataract incisions: Architectural stability and reproducibility","volume":"36","author":"Masket","year":"2010","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3928\/1081597X-20180301-01","article-title":"Comparison of Surgically Induced Astigmatism and Morphologic Features Resulting From Femtosecond Laser and Manual Clear Corneal Incisions for Cataract Surgery","volume":"34","author":"Ferreira","year":"2018","journal-title":"J. Refract. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Latz, C., Asshauer, T., Rathjen, C., and Mirshahi, A. (2021). Femtosecond-Laser Assisted Surgery of the Eye: Overview and Impact of the Low-Energy Concept. Micromachines, 12.","DOI":"10.3390\/mi12020122"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Riemey, J., Latz, C., and Mirshahi, A. (2022). Intraoperative complications of cataract surgery using a low-energy femtosecond laser: Results from a real-world high-volume setting. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0279023"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1515\/aot-2021-0044","article-title":"Femtosecond lasers for eye surgery applications: Historical overview and modern low pulse energy concepts","volume":"10","author":"Asshauer","year":"2021","journal-title":"Adv. Opt. Technol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jcrs.2013.11.028","article-title":"Comparison of morphologic features of clear corneal incisions created with a femtosecond laser or a keratome","volume":"40","author":"Grewal","year":"2014","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"744","DOI":"10.3928\/1081597X-20170921-01","article-title":"Comparison of wound sealability between femtosecond laser\u2013constructed and manual clear corneal incisions in patients undergoing cataract surgery: A pilot study","volume":"33","author":"Uy","year":"2017","journal-title":"J. Refract. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3928\/1081597X-20131217-03","article-title":"Femtosecond laser versus manual clear corneal incision in cataract surgery","volume":"30","author":"Mastropasqua","year":"2014","journal-title":"J. Refract. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2147\/OPTH.S184024","article-title":"Architecture evaluation of the main clear corneal incisions in femtosecond laser-assisted cataract surgery by optical coherence tomography imaging","volume":"13","author":"Chaves","year":"2019","journal-title":"Clin. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1001\/archopht.1993.01090060119035","article-title":"The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group","volume":"111","author":"Chylack","year":"1993","journal-title":"Arch. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF01081875","article-title":"Scalable concept for diode-pumped high-power solid-state lasers","volume":"58","author":"Giesen","year":"1994","journal-title":"Appl. Phys. B"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1364\/OL.17.000505","article-title":"Solid-state low-loss intracavity saturable absorber for Nd: YLF lasers: An antiresonant semiconductor Fabry\u2013Perot saturable absorber","volume":"17","author":"Keller","year":"1992","journal-title":"Opt. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1364\/OL.26.000379","article-title":"Widely turnable pulses durations from a passively mode-locked thin-disk Yb: YAG laser","volume":"26","author":"Brunner","year":"2001","journal-title":"Opt. Lett."},{"key":"ref_20","first-page":"1883","article-title":"Femtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: A prospective, randomized, paired-eye study","volume":"22","author":"Pajic","year":"2014","journal-title":"Clin. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0886-3350(13)80617-7","article-title":"A new method of analyzing vectors for changes in astigmatism","volume":"19","author":"Alpins","year":"1993","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0886-3350(97)80021-1","article-title":"Vector analysis of astigmatism changes by flattening, steepening, and torque","volume":"23","author":"Alpins","year":"1997","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_23","first-page":"1307","article-title":"Effect of femtosecond laser fragmentation on effective phacoemulsification time in cataract surgery","volume":"39","author":"Kohnen","year":"2013","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_24","first-page":"388","article-title":"Comparison of higher-order aberrations and visual outcomes after femtosecond laser\u2013assisted LASIK using two different femtosecond lasers","volume":"30","author":"Tomita","year":"2014","journal-title":"J. Refract. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3928\/1081597X-20140711-04","article-title":"Evaluation of femtosecond laser-assisted and manual clear corneal incisions and their effect on surgically induced astigmatism and higher-order aberrations","volume":"30","author":"Nagy","year":"2014","journal-title":"J. Refract. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3928\/1081597X-20130819-01","article-title":"Femtosecond laser cataract incision morphology and corneal higher-order aberration analysis","volume":"29","author":"Abdou","year":"2013","journal-title":"J. Refract. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3928\/1081597X-20190107-02","article-title":"Higher Order Aberrations in Femtosecond Laser-Assisted Versus Manual Cataract Surgery: A Retrospective Cohort Study","volume":"35","author":"Ernest","year":"2019","journal-title":"J. Refract. Surg."},{"key":"ref_28","first-page":"555","article-title":"Clinical outcomes using standard phacoemulsification and femtosecond laser-assisted surgery with toric intraocular lenses","volume":"10","author":"Espaillat","year":"2016","journal-title":"Clin. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.jcrs.2015.11.004","article-title":"Comparison of surgically induced astigmatism between femtosecond laser and manual clear corneal incisions for cataract surgery","volume":"41","author":"Diakonis","year":"2015","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Shaheen, M.S., AbouSamra, A., Helaly, H.A., Said, A., and Elmassry, A. (2020). Comparison between refractive outcomes of femtosecond laser-assisted cataract surgery and standard phacoemulsification. BMC Ophthalmol., 20.","DOI":"10.1186\/s12886-019-1277-9"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3928\/1081597X-20090101-04","article-title":"Induced astigmatism with 2.2- and 3.0-mm coaxial phacoemulsification incisions","volume":"25","author":"Masket","year":"2009","journal-title":"J. Refract. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.ophtha.2009.11.041","article-title":"Corneal shape changes after 2.0-mm or 3.0-mm clear corneal versus scleral tunnel incision cataract surgery","volume":"117","author":"Hayashi","year":"2010","journal-title":"Ophthalmology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2147\/OPTH.S149709","article-title":"Surgically induced astigmatism after phacoemulsification by temporal clear corneal and superior clear corneal approach: A comparison","volume":"12","author":"Nikose","year":"2018","journal-title":"Clin. Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1364\/OE.8.000631","article-title":"Improvement in retinal image quality with dynamic correction of the eye\u2019s aberrations","volume":"8","author":"Hofer","year":"2001","journal-title":"Opt. Express"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/j.jcrs.2012.08.036","article-title":"Contribution of the posterior cornea to total corneal astigmatism","volume":"38","author":"Koch","year":"2012","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_36","first-page":"349","article-title":"Influence of posterior corneal astigmatism on total corneal astigmatism in a sample of eyes with a wide range of anterior corneal astigmatism","volume":"43","author":"Savini","year":"2017","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jcrs.2016.02.038","article-title":"New regression formula for toric intraocular lens planning considering posterior corneal astigmatism","volume":"42","author":"Abulafia","year":"2016","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1475-1313.2009.00662.x","article-title":"Retinal image quality for virtual eyes generated by a statistical model of ocular wavefront aberrations","volume":"29","author":"Thibos","year":"2009","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.2147\/OPTH.S21819","article-title":"Correlation between contrast sensitivity and higher-order aberration based on pupil diameter after cataract surgery","volume":"5","author":"Yamaguchi","year":"2011","journal-title":"Clin. Ophthalmol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3928\/1081597X-20090610-01","article-title":"Correlation of aberrometry, contrast sensitivity, and subjective symptoms with quality of vision after LASIK","volume":"25","author":"Martin","year":"2009","journal-title":"J. Refract. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00417-021-05441-4","article-title":"Femtosecond laser-assisted cataract surgery versus conventional phacoemulsification: Comparison of internal aberrations and visual quality","volume":"260","author":"Zhong","year":"2022","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jcrs.2018.08.032","article-title":"Femtosecond laser-assisted cataract surgery versus conventional phacoemulsification: Refractive and aberrometric outcomes with a diffractive multifocal intraocular lens","volume":"45","author":"Lee","year":"2019","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Slezak, F., Thumann, G., Kropp, M., Cvejic, Z., De Clerck, E.E.B., Bravetti, G.E., Guber, I., and Pajic, B. (2023). Comparison of Conventional and Femtosecond Laser-Assisted Cataract Surgery Regarding Macula Behavior and Thickness. Medicina, 59.","DOI":"10.3390\/medicina59040639"},{"key":"ref_44","first-page":"e939099","article-title":"Comparison of Vision Correction and Corneal Thickness at 180-Day Follow-Up After Femtosecond Laser-Assisted In-Situ Keratomileusis (FS-LASIK), Photorefractive Keratectomy (PRK), and Small Incision Lenticule Extraction (SMILE): A Study from a Single Center in Poland of 120 Patients with Myopia","volume":"29","author":"Grabarek","year":"2023","journal-title":"Med. Sci. Monit."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Janiszewska-Bil, D., Grabarek, B.O., Lyssek-Boro\u0144, A., Kie\u0142basi\u0144ska, A., Kuraszewska, B., Wyl\u0119ga\u0142a, E., and Krysik, K. (2024). Comparative Analysis of Corneal Wound Healing: Differential Molecular Responses in Tears Following PRK, FS-LASIK, and SMILE Procedures. Biomedicines, 12.","DOI":"10.3390\/biomedicines12102289"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wu, T., Wang, Y., Li, Y., Li, Y., Jiang, X., and Li, X. (2024). The impact of corneal higher-order aberrations on dynamic visual acuity post cataract surgery. Front. Neurosci., 18.","DOI":"10.3389\/fnins.2024.1321423"},{"key":"ref_47","first-page":"437","article-title":"Comparison of corneal wavefront aberrations after photorefractive keratectomy and laser in situ keratomileusis","volume":"141","author":"Oshika","year":"2006","journal-title":"Am. J. Ophthalmol."}],"container-title":["Micromachines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-666X\/16\/8\/939\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:28:36Z","timestamp":1760034516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-666X\/16\/8\/939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":47,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["mi16080939"],"URL":"https:\/\/doi.org\/10.3390\/mi16080939","relation":{},"ISSN":["2072-666X"],"issn-type":[{"value":"2072-666X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,15]]}}}