{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T09:14:53Z","timestamp":1776158093851,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Microfluidics enables spatially controlled nanostructure synthesis by coupling confined flows with surface reactions. In this work, we study how geometry-induced laminar microenvironments govern the in situ formation of Au and Ag nanostructures inside 3D-printed microfluidic reactors. Proof-of-concept fish-scale valves were fabricated by masked stereolithography in three architectures designed to define three recurring zones in the microreactor, inside the fish-scales (zone 1), between the fish-scales (zone 2), and along the rows of fish-scales (zone 3). A Cu thin film was deposited on the inner walls of the channel to serve as the sacrificial surface for galvanic replacement using AgNO3 or HAuCl4. Distinct 0D, 1D, and 2D nanostructures were simultaneously obtained in a zone-dependent manner across the valves, including nanoparticle and nanopore-rich regions, nanowires, nanoflakes and clustered 2D features. COMSOL simulations were used to solve the Navier\u2013Stokes equation and extract specific-zone flow descriptors, including Reynolds number, velocity, and wall shear stress, and relate them to the nanostructure morphologies observed by SEM. The flow throughout the devices is strongly laminar, with local Reynolds numbers up to 0.04, exhibiting systematic spatial gradients imposed by the valve geometry. These results provide a design-guided route to tune nanostructure morphology through microchannel architecture under constant global operating conditions.<\/jats:p>","DOI":"10.3390\/mi17040470","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:14:17Z","timestamp":1776154457000},"page":"470","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study of the Relation Between the Reynolds Number and the Formation of Au and Ag Nanostructures by Flow-Driven Surface Modification in Microfluidic Reactors"],"prefix":"10.3390","volume":"17","author":[{"given":"Oscar","family":"Perez-Landeros","sequence":"first","affiliation":[{"name":"Instituto de Ingenier\u00eda, Universidad Aut\u00f3noma de Baja California, Blvd. Benito Ju\u00e1rez s\/n, Mexicali 21280, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6534-4357","authenticated-orcid":false,"given":"Alan","family":"Garcia-Gallegos","sequence":"additional","affiliation":[{"name":"Instituto de Ingenier\u00eda, Universidad Aut\u00f3noma de Baja California, Blvd. Benito Ju\u00e1rez s\/n, Mexicali 21280, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mateos-Anzaldo","sequence":"additional","affiliation":[{"name":"Instituto de Ingenier\u00eda, Universidad Aut\u00f3noma de Baja California, Blvd. Benito Ju\u00e1rez s\/n, Mexicali 21280, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roumen","family":"Nedev","sequence":"additional","affiliation":[{"name":"Instituto de Ingenier\u00eda, Universidad Aut\u00f3noma de Baja California, Blvd. Benito Ju\u00e1rez s\/n, Mexicali 21280, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3468-5071","authenticated-orcid":false,"given":"Judith","family":"Paz-Delgadillo","sequence":"additional","affiliation":[{"name":"Instituto de Ingenier\u00eda, Universidad Aut\u00f3noma de Baja California, Blvd. Benito Ju\u00e1rez s\/n, Mexicali 21280, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariela","family":"Dominguez-Osuna","sequence":"additional","affiliation":[{"name":"Instituto de Ingenier\u00eda, Universidad Aut\u00f3noma de Baja California, Blvd. Benito Ju\u00e1rez s\/n, Mexicali 21280, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0522-5140","authenticated-orcid":false,"given":"Evelyn","family":"Maga\u00f1a-Leyva","sequence":"additional","affiliation":[{"name":"Instituto de Ingenier\u00eda, Universidad Aut\u00f3noma de Baja California, Blvd. Benito Ju\u00e1rez s\/n, Mexicali 21280, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Salinas-Martinez","sequence":"additional","affiliation":[{"name":"Instituto de Ingenier\u00eda, Universidad Aut\u00f3noma de Baja California, Blvd. Benito Ju\u00e1rez s\/n, Mexicali 21280, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4141-1020","authenticated-orcid":false,"given":"Mario","family":"Curiel-Alvarez","sequence":"additional","affiliation":[{"name":"Instituto de Ingenier\u00eda, Universidad Aut\u00f3noma de Baja California, Blvd. Benito Ju\u00e1rez s\/n, Mexicali 21280, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3762\/bjnano.14.65","article-title":"Silver-based SERS substrates fabricated using a 3D printed microfluidic device","volume":"14","author":"Sonexai","year":"2023","journal-title":"Beilstein J. 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