{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:33:42Z","timestamp":1787045622885,"version":"build-2736575974"},"reference-count":161,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wuxi People\u2019s Hospital\u2013Jiangnan University Joint Research Center for Intelligent Diagnosis and Treatment of Digestive System"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Because lesions associated with digestive system diseases are often deeply seated, embedded within complex luminal milieus, and protected by substantial local delivery barriers, conventional diagnostic and therapeutic modalities remain constrained in their targeting capability, minimal invasiveness, and precision. Microrobots, leveraging micro-scale motion, active navigation, programmable controllability, and theranostic integration, open a new avenue for the precise diagnosis and treatment of digestive system diseases. Here, we review the major actuation modalities and structural designs of microrobots and discuss recent advances in their use across the gastrointestinal and hepatopancreatobiliary systems, focusing on targeted drug delivery, biospecimen harvesting, lesion detection, and interventional treatment. We further discuss the major obstacles to progress in this field, including robust operation in complex in vivo settings, real-time imaging and closed-loop feedback control, biosafety, degradability, and eventual clinical implementation. With continued advances in high-performance materials, multimodal actuation, intelligent control, and convergence with endoscopic and medical imaging technologies, microrobots are poised to accelerate the transition of digestive disease care toward precision, intelligence, and minimally invasive intervention.<\/jats:p>","DOI":"10.3390\/mi17080973","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:06:41Z","timestamp":1787044001000},"page":"973","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microrobots for Precision Diagnosis and Treatment in the Digestive System: A Review of Actuation Mechanisms, Structural Design, Preclinical and Translational Applications"],"prefix":"10.3390","volume":"17","author":[{"given":"Yulong","family":"Gao","sequence":"first","affiliation":[{"name":"The Key Laboratory of Advanced Process Control for Light Industry (Ministry of Education), Institute of Automation, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-2605","authenticated-orcid":false,"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Advanced Process Control for Light Industry (Ministry of Education), Institute of Automation, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2263-0225","authenticated-orcid":false,"given":"Gongxin","family":"Li","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Advanced Process Control for Light Industry (Ministry of Education), Institute of Automation, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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