{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:27:07Z","timestamp":1788881227975,"version":"build-2803163510"},"reference-count":39,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Chagas disease, Trypanosoma cruzi infection, is an insidious cause of heart failure in Latin America. Early diagnosis and treatment are critical to prevent irreversible myocardial damage that progressively accumulates over decades. Several structural barriers account for the less than 1% of cases in Colombia being treated, including poor physician knowledge, especially considering that some regions are considered non-endemic. The two cases reported here represent an emerging epidemiologic scenario associated with pediatric Chagas disease. Both cases are suspected oral transmitted parasitic infection in a geographic region of Colombia (Andean region of Antioquia) where no previous oral transmission of Chagas disease had been reported. Their clinical histories and course of disease are presented here to increase physician awareness of the epidemiologic risk factors and clinical manifestations associated with pediatric oral Chagas disease in Antioquia department, Colombia.<\/jats:p>","DOI":"10.3390\/microorganisms10010008","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T02:01:19Z","timestamp":1640224879000},"page":"8","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute Pediatric Chagas Disease in Antioquia, Colombia: A Geographic Location of Suspected Oral Transmission"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9459-3713","authenticated-orcid":false,"given":"L\u00eddia","family":"Gual-Gonzalez","sequence":"first","affiliation":[{"name":"Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Arango-Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda Hospital San Vicente Fundaci\u00f3n, Medellin 050010, Colombia"},{"name":"Departamento de Pediatr\u00eda, Facultad de Medicina, Universidad de Antioquia, MMedellin 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-0299","authenticated-orcid":false,"given":"Laura Camila","family":"Lopera-Restrepo","sequence":"additional","affiliation":[{"name":"Grupo de Gastrohepatolog\u00eda, Facultad de Medicina, Universidad de Antioquia, Medellin 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1867-3663","authenticated-orcid":false,"given":"Omar","family":"Cantillo-Barraza","sequence":"additional","affiliation":[{"name":"Grupo Biolog\u00eda y Control de Enfermedades Infecciosas, Universidad de Antioquia, Medellin 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1612-5575","authenticated-orcid":false,"given":"Daniela Vel\u00e1squez","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda, Facultad de Medicina, Universidad de Antioquia, MMedellin 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Restrepo","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda, Facultad de Medicina, Universidad de Antioquia, MMedellin 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8031-0225","authenticated-orcid":false,"given":"Omar","family":"Triana-Chavez","sequence":"additional","affiliation":[{"name":"Grupo Biolog\u00eda y Control de Enfermedades Infecciosas, Universidad de Antioquia, Medellin 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8579-5372","authenticated-orcid":false,"given":"Melissa S.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2015). 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