{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:03:39Z","timestamp":1787061819524,"version":"build-2736575974"},"reference-count":15,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The members of the Cryptococcus neoformans and Cryptococcus gattii species complexes are the main etiological agents of cryptococcosis, a life-threatening fungal infection affecting mostly immunocompromised people, but also immunocompetent hosts or those with unrecognized risk factors [...]<\/jats:p>","DOI":"10.3390\/microorganisms10010013","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T21:40:21Z","timestamp":1640295621000},"page":"13","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Recent Advances in Cryptococcus and Cryptococcosis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7547-5172","authenticated-orcid":false,"given":"Carolina","family":"Firacative","sequence":"first","affiliation":[{"name":"Translational Microbiology and Emerging Diseases (MICROS) Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogota 111221, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Trilles","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Micologia, Instituto Nacional de Infectologia Evandro Chagas (INI), Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-8340","authenticated-orcid":false,"given":"Wieland","family":"Meyer","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, Molecular Mycology Research Laboratory, Faculty of Medicine and Health, Sydney Institute for Infectious Diseases, Westmead Hospital-Research and Education Network, Westmead Institute for Medical Research, Sydney Medical School, Westmead Clinical School, University of Sydney, Sydney, NSW 2145, Australia"},{"name":"Curtin Medical School, Curtin University, Bentley, WA 6102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","article-title":"Global burden of disease of HIV-associated cryptococcal meningitis: An updated analysis","volume":"17","author":"Rajasingham","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1534\/genetics.105.046672","article-title":"Multilocus Sequence Typing Reveals Three Genetic Subpopulations of Cryptococcus neoformans var. grubii (Serotype A), Including a Unique Population in Botswana","volume":"172","author":"Litvintseva","year":"2006","journal-title":"Genetics"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ferreira-Paim, K., Andrade-Silva, L., Fonseca, F.M., Ferreira, T.B., Mora, D.J., Andrade-Silva, J., Khan, A., Dao, A., Reis, E.C., and de Almeida, M.T.G. (2017). MLST-Based Population Genetic Analysis in a Global Context Reveals Clonality amongst Cryptococcus neoformans var. grubii VNI Isolates from HIV Patients in Southeastern Brazil. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005223"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e02306-19","DOI":"10.1128\/mBio.02306-19","article-title":"A New Lineage of Cryptococcus gattii (VGV) Discovered in the Central Zambezian Miombo Woodlands","volume":"10","author":"Farrer","year":"2019","journal-title":"mBio"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fgb.2015.02.009","article-title":"Recognition of seven species in the Cryptococcus gattii\/Cryptococcus neoformans species complex","volume":"78","author":"Hagen","year":"2015","journal-title":"Fungal Genet. Biol."},{"key":"ref_6","first-page":"183","article-title":"Frequency and geographical distribution of genotypes and mating types of Cryptococcus neoformans and Cryptococcus gattii species complexes in Argentina","volume":"52","author":"Taverna","year":"2020","journal-title":"Rev. Argent Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e170473","DOI":"10.1590\/0074-02760170473","article-title":"Advances in Cryptococcus genomics: Insights into the evolution of pathogenesis","volume":"113","author":"Cuomo","year":"2018","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e01464-14","DOI":"10.1128\/mBio.01464-14","article-title":"Cryptococcus gattii in North American Pacific Northwest: Whole-Population Genome Analysis Provides Insights into Species Evolution and Dispersal","volume":"5","author":"Engelthaler","year":"2014","journal-title":"mBio"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e01440-19","DOI":"10.1128\/mBio.01440-19","article-title":"Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans Infection","volume":"10","author":"Gerstein","year":"2019","journal-title":"mBio"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1080\/21505594.2019.1614383","article-title":"Basic principles of the virulence of Cryptococcus","volume":"10","author":"Zaragoza","year":"2019","journal-title":"Virulence"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.fgb.2014.09.004","article-title":"Virulence mechanisms and Cryptococcus neoformans pathogenesis","volume":"78","author":"Alspaugh","year":"2014","journal-title":"Fungal Genet. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e170391","DOI":"10.1590\/0074-02760170391","article-title":"The war on cryptococcosis: A Review of the antifungal arsenal","volume":"113","author":"Mourad","year":"2018","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"ref_13","unstructured":"WHO (2018). Guidelines for the Diagnosis, Prevention and Management of Cryptococcal Disease in HIV-Infected Adults, Adolescents and Children: Supplement to the 2016 Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection, WHO."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrmicro.2015.6","article-title":"Cryptococcus: From environmental saprophyte to global pathogen","volume":"14","author":"May","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.idc.2015.10.006","article-title":"Cryptococcosis","volume":"30","author":"Maziarz","year":"2016","journal-title":"Infect. Dis. Clin. N. Am."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/10\/1\/13\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:51:46Z","timestamp":1760169106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/10\/1\/13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,23]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["microorganisms10010013"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms10010013","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,23]]}}}