{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:15:49Z","timestamp":1779912949127,"version":"3.53.1"},"reference-count":35,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The goal of this research was to evaluate seropositivity to HSV-1 among pregnant women and its effect on the course of pregnancy, childbirth and the condition of newborns. Methods: The serological status, socio-demographic characteristics, parity of pregnancy and childbirth and condition of newborns in women seronegative and seropositive to HSV-1 with recurrent infection and its latent course during pregnancy were analyzed. Newborns from these mothers made up the corresponding groups. Results: Low titers of IgG antibodies to HSV-1 in women in the first trimester of pregnancy are associated with threatened miscarriage, anemia in pregnancy and chronic placental insufficiency. High titers of IgG antibodies to HSV-1 in women in the second trimester of pregnancy are associated with late miscarriages and premature births, anemia in pregnancy, chronic placental insufficiency, labor anomalies, early neonatal complications (cerebral ischemia, respiratory distress syndrome) and localized skin rashes. Low titers of IgG antibodies to HSV-1 in women in the third trimester of pregnancy are associated with premature birth, anemia in pregnancy, chronic placental insufficiency, endometritis, complications of the early neonatal period and localized skin rashes. Conclusions: Our research showed that low or high titers of IgG antibodies to HSV-1, determined by the timing of recurrence of infection during pregnancy, are associated with a high incidence of somatic pathology and complications in pregnancy, childbirth and the neonatal period.<\/jats:p>","DOI":"10.3390\/microorganisms10010176","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T20:45:21Z","timestamp":1642365921000},"page":"176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Effect of HSV-1 Seropositivity on the Course of Pregnancy, Childbirth and the Condition of Newborns"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0212-0201","authenticated-orcid":false,"given":"Irina Anatolyevna","family":"Andrievskaya","sequence":"first","affiliation":[{"name":"Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases, Far Eastern Scientific Center of Physiology and Pathology of Respiration, 22 Kalinina Str., 675000 Blagoveshchensk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina Valentinovna","family":"Zhukovets","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Postgraduate Education, Amur State Medical Academy of the Ministry of Health of Russia, 675000 Blagoveshchensk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna Victorovna","family":"Dovzhikova","sequence":"additional","affiliation":[{"name":"Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases, Far Eastern Scientific Center of Physiology and Pathology of Respiration, 22 Kalinina Str., 675000 Blagoveshchensk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1024-1532","authenticated-orcid":false,"given":"Nataliya Alexandrovna","family":"Ishutina","sequence":"additional","affiliation":[{"name":"Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases, Far Eastern Scientific Center of Physiology and Pathology of Respiration, 22 Kalinina Str., 675000 Blagoveshchensk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ksenia Konstantinovna","family":"Petrova","sequence":"additional","affiliation":[{"name":"Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases, Far Eastern Scientific Center of Physiology and Pathology of Respiration, 22 Kalinina Str., 675000 Blagoveshchensk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/cid\/ciy318","article-title":"Seroprevalence of herpes simplex virus types 1 and 2 among pregnant women and sexually active, nonpregnant women in the United States","volume":"67","author":"Patton","year":"2018","journal-title":"Clin. 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