{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:50:46Z","timestamp":1760151046446,"version":"build-2065373602"},"reference-count":50,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Background: The increased production of carbon monoxide (CO) in sepsis has been proven, but the blood level variations of carboxyhemoglobin (COHb) as a potential evolutionary parameter of COVID-19 and sepsis\/septic shock have yet to be determined. This study aims to evaluate the serum level variation of COHb as a potential evolutionary parameter in COVID-19 critically ill patients and in bacterial sepsis. Materials and method: A prospective and observational study was conducted on two groups of patients: the bacterial sepsis group (n = 52) and the COVID-19 group (n = 52). We followed paraclinical parameters on Day 1 (D1) and Day 5 (D5) of sepsis\/ICU admission for COVID-19 patients. Results: D1 of sepsis: statistically significant positive correlations between: COHb values and serum lactate (p = 0.024, r = 0.316), and total bilirubin (p = 0.01, r = 0.359). In D5 of sepsis: a statistically significant positive correlations between: COHb values and procalcitonin (PCT) (p = 0.038, r = 0.402), and total bilirubin (p = 0.023, r = 0.319). D1 of COVID-19 group: COHb levels were statistically significantly positively correlated with C-reactive protein CRP values (p = 0.003, r = 0.407) and with PCT values (p = 0.022, r = 0.324) and statistically significantly negatively correlated with serum lactate values (p = 0.038, r = \u22120.285). Conclusion: COHb variation could provide rapid information about the outcome of bacterial sepsis\/septic shock, having the advantages of a favorable cost-effectiveness ratio, and availability as a point-of-care test.<\/jats:p>","DOI":"10.3390\/microorganisms10020305","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T22:00:56Z","timestamp":1643320856000},"page":"305","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Endogenous Carboxyhemoglobin Level Variation in COVID-19 and Bacterial Sepsis: A Novel Approach?"],"prefix":"10.3390","volume":"10","author":[{"given":"Bianca-Liana","family":"Grigorescu","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, University of Medicine, Pharmacology, Sciences and Technology, 540142 Targu-Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"S\u0103pl\u0103can","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Emergency County Hospital, 540136 Targu-Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7166-9949","authenticated-orcid":false,"given":"Ioana Roxana","family":"Bordea","sequence":"additional","affiliation":[{"name":"Department of Oral Rehabilitation, University of Medicine and Pharmacy Iuliu Hatieganu, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Petrisor","sequence":"additional","affiliation":[{"name":"Department of Simulation Applied in Medicine, University of Medicine, Pharmacology, Sciences and Technology, 540142 Targu-Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5887-8639","authenticated-orcid":false,"given":"Oana","family":"Coman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Emergency County Hospital, 540136 Targu-Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu Ion","family":"Puiac","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu-Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariana","family":"Toncean","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Emergency County Hospital, 540136 Targu-Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca Stefania","family":"Fodor","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu-Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13054-020-02911-9","article-title":"Acute respiratory failure in COVID-19: Is it \u201ctypical\u201d ARDS?","volume":"24","author":"Li","year":"2020","journal-title":"Crit. 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