{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T09:30:10Z","timestamp":1784971810441,"version":"3.55.0"},"reference-count":35,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["075-15-2020-902"],"award-info":[{"award-number":["075-15-2020-902"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Influenza and S. pneumoniae infections are a significant cause of morbidity and mortality worldwide. Intranasal live influenza vaccine (LAIV) may prevent influenza-related bacterial complications. The objectives of the study are to estimate resistance against early influenza infection and post-influenza pneumococcal pneumonia after LAIV in mice. Mice were administered intranasally the monovalent LAIV A\/17\/Mallard Netherlands\/00\/95(H7N3), A\/17\/South Africa\/2013\/01(H1N1)pdm09 or trivalent LAIV 2017\u20132018 years of formulation containing A\/17\/New York\/15\/5364(H1N1)pdm09 vaccine strain. LAIV demonstrated early protection against homologous and heterologous infections with A\/South Africa\/3626\/2013 (H1N1) pdm09 influenza virus on day six, following immunization. Following boost immunization, trivalent LAIV demonstrated a pronounced protective effect both in terms of lethality and pneumococcal lung infection when S. pneumoniae infection was performed three days after the onset of influenza infection. Conclusion: LAIV provides early protection against homologous and heterologous viral infections and has a protective effect against post-influenza pneumococcal infection. These data suggest that the intranasal administration of LAIV may be useful during the cycle of circulation not only of influenza viruses, but also of other causative agents of acute respiratory infections.<\/jats:p>","DOI":"10.3390\/microorganisms10061150","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T11:05:02Z","timestamp":1654167902000},"page":"1150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Live Influenza Vaccine Provides Early Protection against Homologous and Heterologous Influenza and May Prevent Post-Influenza Pneumococcal Infections in Mice"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-3520","authenticated-orcid":false,"given":"Yulia","family":"Desheva","sequence":"first","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the World-Class Research Center \u201cCenter for Personalized Medicine\u201d, Federal State Budgetary Scientific Institution \u201cInstitute of Experimental Medicine\u201d, 12 Academician Pavlov Street, 197376 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-6594","authenticated-orcid":false,"given":"Galina","family":"Leontieva","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the World-Class Research Center \u201cCenter for Personalized Medicine\u201d, Federal State Budgetary Scientific Institution \u201cInstitute of Experimental Medicine\u201d, 12 Academician Pavlov Street, 197376 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Kramskaya","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the World-Class Research Center \u201cCenter for Personalized Medicine\u201d, Federal State Budgetary Scientific Institution \u201cInstitute of Experimental Medicine\u201d, 12 Academician Pavlov Street, 197376 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-7315","authenticated-orcid":false,"given":"Igor","family":"Losev","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the World-Class Research Center \u201cCenter for Personalized Medicine\u201d, Federal State Budgetary Scientific Institution \u201cInstitute of Experimental Medicine\u201d, 12 Academician Pavlov Street, 197376 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Rekstin","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the World-Class Research Center \u201cCenter for Personalized Medicine\u201d, Federal State Budgetary Scientific Institution \u201cInstitute of Experimental Medicine\u201d, 12 Academician Pavlov Street, 197376 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezhda","family":"Petkova","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the World-Class Research Center \u201cCenter for Personalized Medicine\u201d, Federal State Budgetary Scientific Institution \u201cInstitute of Experimental Medicine\u201d, 12 Academician Pavlov Street, 197376 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Kudar","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the World-Class Research Center \u201cCenter for Personalized Medicine\u201d, Federal State Budgetary Scientific Institution \u201cInstitute of Experimental Medicine\u201d, 12 Academician Pavlov Street, 197376 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Suvorov","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the World-Class Research Center \u201cCenter for Personalized Medicine\u201d, Federal State Budgetary Scientific Institution \u201cInstitute of Experimental Medicine\u201d, 12 Academician Pavlov Street, 197376 Saint Petersburg, 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