{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:49:58Z","timestamp":1780559398152,"version":"3.54.1"},"reference-count":42,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32161133025"],"award-info":[{"award-number":["32161133025"]}]},{"name":"National Natural Science Foundation of China","award":["CX(21)1004"],"award-info":[{"award-number":["CX(21)1004"]}]},{"name":"National Natural Science Foundation of China","award":["BE2017341"],"award-info":[{"award-number":["BE2017341"]}]},{"name":"National Natural Science Foundation of China","award":["CX(21)1049"],"award-info":[{"award-number":["CX(21)1049"]}]},{"name":"Jiangsu agricultural science and technology independent innovation funds","award":["32161133025"],"award-info":[{"award-number":["32161133025"]}]},{"name":"Jiangsu agricultural science and technology independent innovation funds","award":["CX(21)1004"],"award-info":[{"award-number":["CX(21)1004"]}]},{"name":"Jiangsu agricultural science and technology independent innovation funds","award":["BE2017341"],"award-info":[{"award-number":["BE2017341"]}]},{"name":"Jiangsu agricultural science and technology independent innovation funds","award":["CX(21)1049"],"award-info":[{"award-number":["CX(21)1049"]}]},{"name":"Key Research and Development Program (Modern Agriculture) Project of Jiangsu Province","award":["32161133025"],"award-info":[{"award-number":["32161133025"]}]},{"name":"Key Research and Development Program (Modern Agriculture) Project of Jiangsu Province","award":["CX(21)1004"],"award-info":[{"award-number":["CX(21)1004"]}]},{"name":"Key Research and Development Program (Modern Agriculture) Project of Jiangsu Province","award":["BE2017341"],"award-info":[{"award-number":["BE2017341"]}]},{"name":"Key Research and Development Program (Modern Agriculture) Project of Jiangsu Province","award":["CX(21)1049"],"award-info":[{"award-number":["CX(21)1049"]}]},{"name":"Jiangsu Agricultural Science and Technology Independent Innovation Funds","award":["32161133025"],"award-info":[{"award-number":["32161133025"]}]},{"name":"Jiangsu Agricultural Science and Technology Independent Innovation Funds","award":["CX(21)1004"],"award-info":[{"award-number":["CX(21)1004"]}]},{"name":"Jiangsu Agricultural Science and Technology Independent Innovation Funds","award":["BE2017341"],"award-info":[{"award-number":["BE2017341"]}]},{"name":"Jiangsu Agricultural Science and Technology Independent Innovation Funds","award":["CX(21)1049"],"award-info":[{"award-number":["CX(21)1049"]}]},{"name":"Priority Academic Development Program of Jiangsu Higher Education Institutions","award":["32161133025"],"award-info":[{"award-number":["32161133025"]}]},{"name":"Priority Academic Development Program of Jiangsu Higher Education Institutions","award":["CX(21)1004"],"award-info":[{"award-number":["CX(21)1004"]}]},{"name":"Priority Academic Development Program of Jiangsu Higher Education Institutions","award":["BE2017341"],"award-info":[{"award-number":["BE2017341"]}]},{"name":"Priority Academic Development Program of Jiangsu Higher Education Institutions","award":["CX(21)1049"],"award-info":[{"award-number":["CX(21)1049"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Listeria monocytogenes (Lm) is a ubiquitous foodborne pathogen comprising of 14 serotypes, of which serovar 4h isolates belonging to hybrid sub-lineage \u2161 exhibit hypervirulent features. LMxysn_1693 of serovar 4h Lm XYSN, a member of genomic island-7 (GI-7), is predicted to a membrane protein with unknown function, which is conserved in serovar 4h Listeria monocytogenes. Under bile salts stress, Lm XYSN strain lacking LMxysn_1693 (XYSN\u22061693) exhibited a stationary phase growth defect as well as a reduction in biofilm formation and strikingly down-regulated bile-salts-resistant genes and virulent genes. Particularly, LMxysn_1693 protein plays a crucial role in Lm XYSN adhesion and invasion to intestinal epithelial cells, as well as colonization in the ileum of mice. Taken together, these findings indicate that the LMxysn_1693 gene encodes a component of the putative ABC transporter system, synthetically interacts with genes involved in bile resistance, biofilm formation and virulence, and thus contributes to Listeria monocytogenes survival within and outside the host.<\/jats:p>","DOI":"10.3390\/microorganisms10071263","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:12:01Z","timestamp":1655871121000},"page":"1263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Transmembrane Protein LMxysn_1693 of Serovar 4h Listeria monocytogenes Is Associated with Bile Salt Resistance and Intestinal Colonization"],"prefix":"10.3390","volume":"10","author":[{"given":"Fanxin","family":"Jin","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis, Yangzhou University, 48 East Wenhui Road, Yangzhou 225009, China"},{"name":"Key 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Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0168-1605(96)00945-2","article-title":"Mathematically modeling the repair of heat-injured Listeria monocytogenes as affected by temperature, pH, and salt concentration","volume":"30","author":"Chawla","year":"1996","journal-title":"Int. J. Food Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodcont.2016.12.016","article-title":"A review of Listeria monocytogenes: An update on outbreaks, virulence, dose-response, ecology, and risk assessments","volume":"75","author":"Buchanan","year":"2017","journal-title":"Food Control"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1099\/ijsem.0.002596","article-title":"Listeria costaricensis sp. nov","volume":"68","author":"Leclercq","year":"2018","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e00396-18","DOI":"10.1128\/mBio.00396-18","article-title":"Listeria monocytogenes source distribution analysis indicates regional heterogeneity and ecological niche preference among serotype 4b clones","volume":"9","author":"Lee","year":"2018","journal-title":"MBio"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1038\/s41467-019-12072-1","article-title":"A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates","volume":"10","author":"Yin","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"109440","DOI":"10.1016\/j.enzmictec.2019.109440","article-title":"Modulatory effect of low-shear modeled microgravity on stress resistance, membrane lipid composition, virulence, and relevant gene expression in the food-borne pathogen Listeria monocytogenes","volume":"133","author":"Sheet","year":"2020","journal-title":"Enzyme Microb. Technol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1046\/j.1365-2958.2001.02398.x","article-title":"A glutamate decarboxylase system protects Listeria monocytogenes in gastric fluid","volume":"40","author":"Cotter","year":"2001","journal-title":"Mol. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1749-6632.1982.tb25730.x","article-title":"Structure and genetics of the H+-conducting F0 portion of the ATP synthase","volume":"402","author":"Sebald","year":"1982","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1128\/AEM.00952-10","article-title":"Transcriptomic and phenotypic analyses identify coregulated, overlapping regulons among PrfA, CtsR, HrcA, and the alternative sigma factors sigmaB, sigmaC, sigmaH, and sigmaL in Listeria monocytogenes","volume":"77","author":"Chaturongakul","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1128\/IAI.73.2.894-904.2005","article-title":"Contribution of three bile-associated loci, bsh, pva, and btlB, to gastrointestinal persistence and bile tolerance of Listeria monocytogenes","volume":"73","author":"Begley","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1080\/19490976.2020.1712983","article-title":"Virulence gene repression promotes Listeria monocytogenes systemic infection","volume":"11","author":"Pombinho","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.fm.2011.12.015","article-title":"Occurrence and characterization of Listeria spp. in ready-to-eat retail foods from Vancouver, British Columbia","volume":"30","author":"Mesak","year":"2012","journal-title":"Food Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lee, S., Parsons, C., Chen, Y., Hanafy, Z., Brown, E., and Kathariou, S. (2021). Identification and characterization of a novel genomic island harboring cadmium and arsenic resistance genes in Listeria welshimeri. Biomolecules, 11.","DOI":"10.3390\/biom11040560"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1128\/jb.179.7.2097-2102.1997","article-title":"CTnscr94, a conjugative transposon found in enterobacteria","volume":"179","author":"Hochhut","year":"1997","journal-title":"J. Bacteriol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0378-1119(90)90479-B","article-title":"High-efficiency transformation of Listeria monocytogenes by electroporation of penicillin-treated cells","volume":"94","author":"Park","year":"1990","journal-title":"Gene"},{"key":"ref_17","first-page":"1865","article-title":"The role of stress and stress adaptations in determining the fate of the bacterial pathogen Listeria monocytogenes in the food chain","volume":"7","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.tifs.2009.01.054","article-title":"Biofilm formation and food safety in food industries","volume":"20","author":"Shi","year":"2009","journal-title":"Trends Food Sci. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"617473","DOI":"10.3389\/fmicb.2020.617473","article-title":"Inhibition of biofilm formation and related gene expression of Listeria monocytogenes in response to four natural antimicrobial compounds and sodium hypochlorite","volume":"11","author":"Liu","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijfoodmicro.2012.11.027","article-title":"Incorporation of Listeria monocytogenes strains in raw milk biofilms","volume":"161","author":"Weiler","year":"2013","journal-title":"Int. J. Food Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1128\/IAI.00330-10","article-title":"Investigation of the mechanisms by which Listeria monocytogenes grows in porcine gallbladder bile","volume":"79","author":"Dowd","year":"2011","journal-title":"Infect. Immun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1016\/j.bbagen.2016.09.024","article-title":"Molecular features of bile salt hydrolases and relevance in human health","volume":"1861","author":"Chand","year":"2017","journal-title":"Biochim. Biophys. Acta. Gen. Subj."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1128\/IAI.06286-11","article-title":"Hyperinduction of host beta interferon by a Listeria monocytogenes strain naturally overexpressing the multidrug efflux pump MdrT","volume":"80","author":"Schwartz","year":"2012","journal-title":"Infect. Immun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijfoodmicro.2010.12.028","article-title":"SigB plays a major role in Listeria monocytogenes tolerance to bile stress","volume":"145","author":"Zhang","year":"2011","journal-title":"Int. J. Food Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1046\/j.1365-2958.2002.03080.x","article-title":"Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis","volume":"45","author":"Dussurget","year":"2002","journal-title":"Mol. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/j.1365-2958.2004.04454.x","article-title":"A PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes","volume":"55","author":"Sleator","year":"2005","journal-title":"Mol. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1365-2958.2011.07683.x","article-title":"The novel Listeria monocytogenes bile sensor BrtA controls expression of the cholic acid efflux pump MdrT","volume":"81","author":"Quillin","year":"2011","journal-title":"Mol. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"103377","DOI":"10.1016\/j.fm.2019.103377","article-title":"Quercetin repressed the stress response factor (sigB) and virulence genes (prfA, actA, inlA, and inlC), lower the adhesion, and biofilm development of L. monocytogenes","volume":"87","year":"2020","journal-title":"Food Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1128\/JB.00179-10","article-title":"The virulence regulator PrfA promotes biofilm formation by Listeria monocytogenes","volume":"192","author":"Lemon","year":"2010","journal-title":"J. Bacteriol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nature08080","article-title":"The Listeria transcriptional landscape from saprophytism to virulence","volume":"459","author":"Dussurget","year":"2009","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3389\/fmicb.2020.00556","article-title":"A putative efflux transporter of the ABC family, YbhFSR, in Escherichia coli functions in tetracycline efflux and Na+(Li+)\/H+ transport","volume":"11","author":"Feng","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"587035","DOI":"10.3389\/fmicb.2021.587035","article-title":"Influence of the ABC transporter YtrBCDEF of Bacillus subtilis on competence, biofilm formation and cell wall thickness","volume":"12","author":"Benda","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e01981-17","DOI":"10.1128\/AAC.01981-17","article-title":"The ABC of biofilm drug tolerance: The MerR-like regulator BrlR is an activator of ABC transport systems, with PA1874-77 contributing to the tolerance of Pseudomonas aeruginosa biofilms to tobramycin","volume":"62","author":"Poudyal","year":"2018","journal-title":"Antimicrob. Agents. Chemother."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Pinweha, P., Pumirat, P., Cuccui, J., Jitprasutwit, N., Muangsombut, V., Srinon, V., Boonyuen, U., Thiennimitr, P., Vattanaviboon, P., and Cia, F. (2018). Inactivation of bpsl1039-1040 ATP-binding cassette transporter reduces intracellular survival in macrophages, biofilm formation and virulence in the murine model of Burkholderia pseudomallei infection. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0196202"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e01470-19","DOI":"10.1128\/AEM.01470-19","article-title":"The VirAB-VirSR-AnrAB multicomponent system is involved in resistance of Listeria monocytogenes EGD-e to cephalosporins, bacitracin, nisin, benzalkonium chloride, and ethidium bromide","volume":"85","author":"Jiang","year":"2019","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e00901-17","DOI":"10.1128\/IAI.00901-17","article-title":"The VirAB ABC transporter is required for VirR regulation of Listeria monocytogenes virulence and resistance to nisin","volume":"86","author":"Grubaugh","year":"2018","journal-title":"Infect. Immun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1128\/AAC.00503-10","article-title":"The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics","volume":"54","author":"Collins","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1128\/AEM.00648-15","article-title":"VirR-mediated resistance of Listeria monocytogenes against food antimicrobials and cross-protection induced by exposure to organic acid salts","volume":"81","author":"Kang","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Rismondo, J., and Schulz, L.M. (2021). Not just transporters: Alternative functions of ABC transporters in Bacillus subtilis and Listeria monocytogenes. Microorganisms, 9.","DOI":"10.3390\/microorganisms9010163"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5302","DOI":"10.1128\/jb.178.17.5302-5308.1996","article-title":"Requirement for genes with homology to ABC transport systems for attachment and virulence of Agrobacterium tumefaciens","volume":"178","author":"Matthysse","year":"1996","journal-title":"J. Bacteriol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/22221751.2020.1714488","article-title":"ATP-binding cassette (ABC) import systems of Mycobacterium tuberculosis: Target for drug and vaccine development","volume":"9","author":"Soni","year":"2020","journal-title":"Emerg. Microbes. Infect."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nsmb.3216","article-title":"Mechanistic diversity in ATP-binding cassette (ABC) transporters","volume":"23","author":"Locher","year":"2016","journal-title":"Nat. Struct. Mol. Biol."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/10\/7\/1263\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:36:48Z","timestamp":1760139408000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/10\/7\/1263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":42,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["microorganisms10071263"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms10071263","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]}}}