{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:58:19Z","timestamp":1791557899993,"version":"4.3.4"},"reference-count":147,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T00:00:00Z","timestamp":1657411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Early in the 1900s, it was proposed that health could be improved and senility delayed by manipulating gut microbiota with the host-friendly bacteria found in yogurt. Later, in 1990, the medical community reconsidered this idea and today probiotics represent a developed area of research with a billion-dollar global industry. As a result, in recent decades, increased attention has been paid to the isolation and characterization of novel probiotic bacteria from fermented foods and dairy products. Most of the identified probiotic strains belong to the lactic acid bacteria group and the genus Bifidobacterium. However, current molecular-based knowledge has allowed the identification and culture of obligatory anaerobic commensal bacteria from the human gut, such as Akkermansia spp. and Faecalibacterium spp., among other human symbionts. We are aware that the identification of new strains of these species does not guarantee their probiotic effects and that each effect must be proved through in vitro and in vivo preclinical studies before clinical trials (before even considering it as a probiotic strain). In most cases, the identification and characterization of new probiotic strain candidates may lack the appropriate set of in vitro experiments allowing the next assessment steps. Here, we address some innovative strategies reported in the literature as alternatives to classical characterization: (i) identification of alternatives using whole-metagenome shotgun sequencing, metabolomics, and multi-omics analysis; and (ii) probiotic characterization based on molecular effectors and\/or traits to target specific diseases (i.e., inflammatory bowel diseases, colorectal cancer, allergies, among others).<\/jats:p>","DOI":"10.3390\/microorganisms10071389","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:06:21Z","timestamp":1657497981000},"page":"1389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Strategies for the Identification and Assessment of Bacterial Strains with Specific Probiotic Traits"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3359-4517","authenticated-orcid":false,"given":"Edgar","family":"Torres-Maravilla","sequence":"first","affiliation":[{"name":"INRAE, AgroParisTech, Micalis Institute, Universit\u00e9 Paris-Saclay, 78350 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Reyes-Pav\u00f3n","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de Baja California, Mexicali 21000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-1617","authenticated-orcid":false,"given":"Antonio","family":"Ben\u00edtez-Cabello","sequence":"additional","affiliation":[{"name":"Food Biotechnology Department, Instituto de la Grasa (CSIC), Ctra. Utrera Km 1, Building 46, 41013 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Gonz\u00e1lez-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biotecnolog\u00eda, Departamento de Sistemas Biol\u00f3gicos, CONACYT-Universidad Aut\u00f3noma Metropolitana Xochimilco, Mexico City 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Ram\u00edrez-Chamorro","sequence":"additional","affiliation":[{"name":"INRAE, AgroParisTech, Micalis Institute, Universit\u00e9 Paris-Saclay, 78350 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Langella","sequence":"additional","affiliation":[{"name":"INRAE, AgroParisTech, Micalis Institute, Universit\u00e9 Paris-Saclay, 78350 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7525-3131","authenticated-orcid":false,"given":"Luis G.","family":"Berm\u00fadez-Humar\u00e1n","sequence":"additional","affiliation":[{"name":"INRAE, AgroParisTech, Micalis Institute, Universit\u00e9 Paris-Saclay, 78350 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3920\/BM2014.0103","article-title":"The history of probiotics: The untold story","volume":"6","author":"Ozen","year":"2015","journal-title":"Benef. 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