{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:06:30Z","timestamp":1785006390396,"version":"3.55.0"},"reference-count":37,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The variety of placental morphological findings with SARS-CoV-2 maternal infections has raised the issue of poor agreement in histopathological evaluation. The aims of this study were: to describe the histopathological placental features of a large sample of SARS-CoV-2-positive women who gave birth in Italy during the COVID-19 pandemic, to analyse the factors underlying these lesions, and to analyse the impact of placental impairment on perinatal outcomes. From 25 February 2020 to 30 June 2021, experienced perinatal pathologists examined 975 placentas of SARS-CoV-2-positive mothers enrolled in a national prospective study, adopting the Amsterdam Consensus Statement protocol. The main results included the absence of specific pathological findings for SARS-CoV-2 infections, even though a high proportion of placentas showed signs of inflammation, possibly related to a cytokine storm induced by the virus, without significant perinatal consequences. Further research is needed to better define the clinical implications of placental morphology in SARS-CoV-2 infections, but the results of this large cohort suggest that placentas do not seem to be a preferential target for the new Coronavirus infection.<\/jats:p>","DOI":"10.3390\/microorganisms10071435","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T01:53:22Z","timestamp":1658109202000},"page":"1435","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Placental Characteristics of a Large Italian Cohort of SARS-CoV-2-Positive Pregnant Women"],"prefix":"10.3390","volume":"10","author":[{"given":"Michele Antonio","family":"Salvatore","sequence":"first","affiliation":[{"name":"National Centre for Disease Prevention and Health Promotion, Istituto Superiore di Sanit\u00e0\u2014Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-2666","authenticated-orcid":false,"given":"Edoardo","family":"Corsi Decenti","sequence":"additional","affiliation":[{"name":"National Centre for Disease Prevention and Health Promotion, Istituto Superiore di Sanit\u00e0\u2014Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy"},{"name":"Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Bonasoni","sequence":"additional","affiliation":[{"name":"Pathology Unit, Azienda Unit\u00e0 Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico di Reggio Emilia, 42122 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Botta","sequence":"additional","affiliation":[{"name":"Department of Foetal and Maternal Pathology, Sant\u2019Anna Hospital, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Castiglione","sequence":"additional","affiliation":[{"name":"Histopathology and Molecular Diagnostics, Careggi University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"D\u2019Armiento","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezio","family":"Fulcheri","sequence":"additional","affiliation":[{"name":"Fetal-Perinatal Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Giannina Gaslini, 16147 Genoa, Italy"},{"name":"Division of Anatomic Pathology, Department of Surgical and Diagnostic Sciences (DISC), University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Nebuloni","sequence":"additional","affiliation":[{"name":"Pathology Unit, ASST Fatebenefratelli Sacco, Department of Biological and Clinical Sciences, University of Milan, 20157 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Donati","sequence":"additional","affiliation":[{"name":"National Centre for Disease Prevention and Health Promotion, Istituto Superiore di Sanit\u00e0\u2014Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ItOSS COVID-19 Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"ref_1","unstructured":"(2022, June 15). 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