{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:46:26Z","timestamp":1781250386089,"version":"3.54.1"},"reference-count":44,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hallym University Research Fund","award":["NRF-2018M3A9F3020956"],"award-info":[{"award-number":["NRF-2018M3A9F3020956"]}]},{"name":"Hallym University Research Fund","award":["NRF-2019R1I1A3A01060447"],"award-info":[{"award-number":["NRF-2019R1I1A3A01060447"]}]},{"name":"Hallym University Research Fund","award":["NRF-2020R1I1A3073530"],"award-info":[{"award-number":["NRF-2020R1I1A3073530"]}]},{"name":"Hallym University Research Fund","award":["NRF-2020R1A6A1A03043026"],"award-info":[{"award-number":["NRF-2020R1A6A1A03043026"]}]},{"name":"Basic Science Research Program","award":["NRF-2018M3A9F3020956"],"award-info":[{"award-number":["NRF-2018M3A9F3020956"]}]},{"name":"Basic Science Research Program","award":["NRF-2019R1I1A3A01060447"],"award-info":[{"award-number":["NRF-2019R1I1A3A01060447"]}]},{"name":"Basic Science Research Program","award":["NRF-2020R1I1A3073530"],"award-info":[{"award-number":["NRF-2020R1I1A3073530"]}]},{"name":"Basic Science Research Program","award":["NRF-2020R1A6A1A03043026"],"award-info":[{"award-number":["NRF-2020R1A6A1A03043026"]}]},{"name":"Ministry of Education, Science and Technology","award":["NRF-2018M3A9F3020956"],"award-info":[{"award-number":["NRF-2018M3A9F3020956"]}]},{"name":"Ministry of Education, Science and Technology","award":["NRF-2019R1I1A3A01060447"],"award-info":[{"award-number":["NRF-2019R1I1A3A01060447"]}]},{"name":"Ministry of Education, Science and Technology","award":["NRF-2020R1I1A3073530"],"award-info":[{"award-number":["NRF-2020R1I1A3073530"]}]},{"name":"Ministry of Education, Science and Technology","award":["NRF-2020R1A6A1A03043026"],"award-info":[{"award-number":["NRF-2020R1A6A1A03043026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Gut microbiota performs indispensable functions in the pathophysiology of alcoholic hepatitis (AH). We investigated the effects of Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus for gut microbial restoration toward eubiosis in patients with AH. A multicenter, double-blind, and randomized trial was conducted. Probiotics (n = 44) and placebo (n = 45) groups received, during 7 days, L. rhamnosus R0011\/L. helveticus R0052 at 120 mg\/day and placebo. All patients were hospitalized to ensure abstinence. Liver function, lipopolysaccharide level, and stool analysis were evaluated in patients before and after 7 days of treatment. At baseline, the dominant bacteria were Gram-negative in both groups which decreased after the probiotics treatment and exhibited a significant reduction in lipopolysaccharide level (p &lt; 0.001). The probiotics ameliorated the Child\u2013Pugh scores (p &lt; 0.001). Furthermore, the probiotics group showed a decline in the levels of alanine aminotransferase and gamma-glutamyltranspeptidase (p &lt; 0.05). The probiotics changed the gut microbial composition at various taxonomical levels. The proportion of Bacteroidetes (147%) was increased after 7 days of probiotics supplementation while Proteobacteria (30%) and Fusobacteria (0%) were decreased. Administration of L. rhamnosus R0011 and L. helveticus R0052 conceivably associated with restoration of gut microbiome in AH patients and improved AH by modulating the gut\u2013liver axis.<\/jats:p>","DOI":"10.3390\/microorganisms10071474","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T22:38:50Z","timestamp":1658443130000},"page":"1474","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Beneficial Shifts in Gut Microbiota by Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 in Alcoholic Hepatitis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6008-1143","authenticated-orcid":false,"given":"Haripriya","family":"Gupta","sequence":"first","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea Institute of Science and Technology, Gangneung 25451, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seul Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hak","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hallym University College of Medicine, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-2331","authenticated-orcid":false,"given":"Hak Cheol","family":"Kwon","sequence":"additional","affiliation":[{"name":"Korea Institute of Science and Technology, Gangneung 25451, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9206-9245","authenticated-orcid":false,"given":"Ki Tae","family":"Suk","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1056\/NEJMra0805786","article-title":"Alcoholic hepatitis","volume":"360","author":"Lucey","year":"2009","journal-title":"N. 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