{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:09:19Z","timestamp":1788667759001,"version":"build-2803163510"},"reference-count":58,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)","award":["21140361"],"award-info":[{"award-number":["21140361"]}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)","award":["3180408"],"award-info":[{"award-number":["3180408"]}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)","award":["SA77210078"],"award-info":[{"award-number":["SA77210078"]}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)","award":["37.0\/2017"],"award-info":[{"award-number":["37.0\/2017"]}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)","award":["37.0\/2021"],"award-info":[{"award-number":["37.0\/2021"]}]},{"name":"Pontificia Universidad Cat\u00f3lica de Valpara\u00edso","award":["21140361"],"award-info":[{"award-number":["21140361"]}]},{"name":"Pontificia Universidad Cat\u00f3lica de Valpara\u00edso","award":["3180408"],"award-info":[{"award-number":["3180408"]}]},{"name":"Pontificia Universidad Cat\u00f3lica de Valpara\u00edso","award":["SA77210078"],"award-info":[{"award-number":["SA77210078"]}]},{"name":"Pontificia Universidad Cat\u00f3lica de Valpara\u00edso","award":["37.0\/2017"],"award-info":[{"award-number":["37.0\/2017"]}]},{"name":"Pontificia Universidad Cat\u00f3lica de Valpara\u00edso","award":["37.0\/2021"],"award-info":[{"award-number":["37.0\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Nowadays, antimicrobial resistance is a serious concern associated with the reduced efficacy of traditional antibiotics and an increased health burden worldwide. In response to this challenge, the scientific community is developing a new generation of antibacterial molecules. Contributing to this effort, and inspired by the resveratrol structure, five new resveratrol-dimers (9a\u20139e) and one resveratrol-monomer (10a) were synthetized using 2,5-dibromo-1,4-diaminobenzene (8) as the core compound for Schiff base bridge conformation. These compounds were evaluated in vitro against pathogenic clinical isolates of Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus sp., and Listeria monocytogenes. Antibacterial activity measurements of resveratrol-Schiff base derivatives (9a\u20139e) and their precursors (4\u20138) showed high selectivity against Listeria monocytogenes, being 2.5 and 13.7 times more potent than chloramphenicol, while resveratrol showed an EC50 &gt; 320 \u00b5g\/mL on the same model. Moreover, a prospective mechanism of action for these compounds against L. monocytogenes strains was proposed using molecular docking analysis, finding a plausible inhibition of internalin C (InlC), a surface protein relevant in bacteria\u2013host interaction. These results would allow for the future development of new molecules for listeriosis treatment based on compound 8.<\/jats:p>","DOI":"10.3390\/microorganisms10081483","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T01:42:13Z","timestamp":1658713333000},"page":"1483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Resveratrol-Schiff Base Hybrid Compounds with Selective Antibacterial Activity: Synthesis, Biological Activity, and Computational Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Rodrigo","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica, Facultad de Ciencias, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso 2373223, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Leyton","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Facultad de Ciencias, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso 2373223, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6038-3475","authenticated-orcid":false,"given":"Luis F.","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Facultad de Ciencias, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso 2373223, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5842-9307","authenticated-orcid":false,"given":"Mauricio","family":"Reyna-Jeldes","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad Cat\u00f3lica del Norte, Coquimbo 1781421, Chile"},{"name":"Millennium Nucleus for the Study of Pain (MiNuSPain), Santiago 8330025, Chile"},{"name":"N\u00facleo para el Estudio del C\u00e1ncer a Nivel B\u00e1sico, Aplicado y Cl\u00ednico, Universidad Cat\u00f3lica del Norte, Antofagasta 1270709, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5297-3694","authenticated-orcid":false,"given":"Claudio","family":"Coddou","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad Cat\u00f3lica del Norte, Coquimbo 1781421, Chile"},{"name":"Millennium Nucleus for the Study of Pain (MiNuSPain), Santiago 8330025, Chile"},{"name":"N\u00facleo para el Estudio del C\u00e1ncer a Nivel B\u00e1sico, Aplicado y Cl\u00ednico, Universidad Cat\u00f3lica del Norte, Antofagasta 1270709, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7345-1123","authenticated-orcid":false,"given":"Katy","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Valpara\u00edso 2390123, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9577-5180","authenticated-orcid":false,"given":"Marco","family":"Mellado","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n y Postgrado, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago 8330507, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.3389\/fmicb.2018.02928","article-title":"Antibiotic resistance mechanisms in bacteria: Relationships between resistance determinants of antibiotic producers, environmental bacteria, and clinical pathogens","volume":"9","author":"Peterson","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1586\/14787210.2014.956092","article-title":"Mechanisms of antibiotic resistance in enterococci","volume":"12","author":"Miller","year":"2014","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1002\/cmdc.201800463","article-title":"Gram-positive and Gram-negative antibiotic activity of asymmetric and monomeric robenidine analogues","volume":"13","author":"Russell","year":"2018","journal-title":"ChemMedChem"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1002\/cmdc.200900157","article-title":"Beta-lactones decrease the intracellular virulence of Listeria monocytogenes in macrophages","volume":"4","author":"Sieber","year":"2009","journal-title":"ChemMedChem"},{"key":"ref_5","unstructured":"O\u2019Neill, J. (2016). Tackling Drug-resistant Infections Globally: Final Report and Recommendations, Review on Antimicrobial Resistance."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1002\/anie.200600350","article-title":"Antibacterial natural products in medicinal chemistry\u2014exodus or revival?","volume":"45","author":"Brands","year":"2006","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e01296-18","DOI":"10.1128\/AAC.01296-18","article-title":"Identification of FDA-approved drugs as antivirulence agents targeting the quorum-sensing system of Pseudomonas aeruginosa","volume":"62","author":"Baldelli","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e00686-17","DOI":"10.1128\/AAC.00686-17","article-title":"Synergistic efficacy of Aedes aegypti antimicrobial peptide cecropin A2 and tetracycline against Pseudomonas aeruginosa","volume":"61","author":"Zheng","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Qiu, J., Wang, D., Xiang, H., Feng, H., Jiang, Y., Xia, L., Dong, J., Lu, J., Yu, L., and Deng, X. (2010). Subinhibitory concentrations of thymol reduce enterotoxins A and B and \u03b1-hemolysin production in Staphylococcus aureus isolates. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009736"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11414","DOI":"10.1038\/s41598-017-11597-z","article-title":"MALDI-TOF-MS based identification and molecular characterization of food associated methicillin-resistant Staphylococcus aureus","volume":"7","author":"Manukumar","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e01651-16","DOI":"10.1128\/AAC.01651-16","article-title":"Penicillin-binding protein 3 is essential for growth of Pseudomonas aeruginosa","volume":"61","author":"Chen","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.jiph.2019.11.013","article-title":"Evaluation of multidrug-resistant Bacillus strains causing public health risks in powdered infant milk formulas","volume":"13","author":"Alanber","year":"2020","journal-title":"J. Infect. Public Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"b319","DOI":"10.1136\/bmj.b319","article-title":"Listeriosis remains a cause for concern in Europe","volume":"338","author":"Watson","year":"2009","journal-title":"Br. Med. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"107461","DOI":"10.1016\/j.biotechadv.2019.107461","article-title":"Whole-cell biocatalytic, enzymatic and green chemistry methods for the production of resveratrol and its derivatives","volume":"39","author":"Jeandet","year":"2020","journal-title":"Biotechnol. Adv."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11130-021-00897-5","article-title":"Synthesis of resveratrol loaded hybrid silica-PAMAM dendrimer nanoparticles with emphases on inducible nitric oxide synthase and cytotoxicity","volume":"76","author":"Nalbantsoy","year":"2021","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10288","DOI":"10.1021\/jf0621828","article-title":"Protection of lipids from oxidation by epicatechin, trans-resveratrol, and gallic and caffeic acids in intestinal model systems","volume":"54","author":"Kerem","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2174\/1568026619666190301173958","article-title":"Resveratrol in various pockets: A review","volume":"19","author":"Kataria","year":"2019","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1901115","DOI":"10.1002\/mnfr.201901115","article-title":"Resveratrol derivative, trans-3, 5, 4\u2032-trimethoxystilbene, prevents the developing of atherosclerotic lesions and attenuates cholesterol accumulation in macrophage foam cells","volume":"64","author":"Hong","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ijantimicag.2019.02.015","article-title":"Antibacterial and antifungal properties of resveratrol","volume":"53","author":"Vestergaard","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Mellado, M., Gonz\u00e1lez, C., Mella, J., Aguilar, L.F., Celik, I., Borges, F., Uriarte, E., Delogu, G., Vi\u00f1a, D., and Matos, M.J. (2022). Coumarin-resveratrol-inspired hybrids as monoamine oxidase B inhibitors: 3-Phenylcoumarin versus trans-6-styrylcoumarin. Molecules, 27.","DOI":"10.3390\/molecules27030928"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Salla, M., Pandya, V., Bhullar, K.S., Kerek, E., Wong, Y.F., Losch, R., Ou, J., Aldawsari, F.S., Velazquez-Martinez, C., and Thiesen, A. (2020). Resveratrol and resveratrol-aspirin hybrid compounds as potent intestinal anti-inflammatory and anti-tumor drugs. Molecules, 25.","DOI":"10.3390\/molecules25173849"},{"key":"ref_22","first-page":"633","article-title":"Design, synthesis, and biological evaluation of ligustrazine\/resveratrol hybrids as potential anti-ischemic stroke agents","volume":"18","author":"Zhang","year":"2020","journal-title":"Chin. J. Nat. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103707","DOI":"10.1016\/j.bioorg.2020.103707","article-title":"Pyridoxine-resveratrol hybrids as novel inhibitors of MAO-B with antioxidant and neuroprotective activities for the treatment of Parkinson\u2019s disease","volume":"97","author":"Li","year":"2020","journal-title":"Bioorg. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1016\/j.bmc.2017.07.057","article-title":"Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities","volume":"25","author":"Thakkar","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.arabjc.2017.05.004","article-title":"Diazenyl schiff bases: Synthesis, spectral analysis, antimicrobial studies and cytotoxic activity on human colorectal carcinoma cell line (HCT-116)","volume":"13","author":"Kaur","year":"2020","journal-title":"Arab. J. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1515\/chem-2018-0020","article-title":"Synthesis, characterization, in-vitro antimicrobial properties, molecular docking and DFT studies of 3-{(E)-[(4,6-dimethylpyrimidin-2-yl)imino]methyl} naphthalen-2-ol and Heteroleptic Mn(II), Co(II), Ni(II) and Zn(II) complexes","volume":"16","author":"Chioma","year":"2018","journal-title":"Open Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10870-005-9053-5","article-title":"Spectroscopic studies, antimicrobial activities, and crystal structure of N-[2-hydroxy-1-naphthylidene]3, 5-bis(trifluoromethyl)aniline","volume":"36","author":"Kiraz","year":"2006","journal-title":"J. Chem. Crystallogr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.molstruc.2004.10.029","article-title":"Spectroscopic study, antimicrobial activity and crystal structures of N-(2-hydroxy-5-nitrobenzalidene)4-aminomorpholine and N-(2-hydroxy-1-naphthylidene)4-aminomorpholine","volume":"738","author":"Erdener","year":"2005","journal-title":"J. Mol. Struct."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"103807","DOI":"10.1016\/j.bioorg.2020.103807","article-title":"Discovery of novel multi-substituted benzo-indole pyrazole schiff base derivatives with antibacterial activity targeting DNA gyrase","volume":"99","author":"Liu","year":"2020","journal-title":"Bioorg. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11723","DOI":"10.1021\/ja00105a013","article-title":"Imine-bridged planar poly(p-phenylene) derivatives for maximization of extended.pi.-conjugation. The common intermediate approach","volume":"116","author":"Lamba","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1039\/C7CE00157F","article-title":"Synthesis of steroidal molecular compasses: Exploration of the controlled assembly of solid organic materials","volume":"19","author":"Santillan","year":"2017","journal-title":"CrystEngComm"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11243-013-9766-9","article-title":"Synthesis of bromine- or aryl-substituted ditopic Schiff base ligands and their bimetallic iron(II) complexes: Electronic and magnetic properties","volume":"39","author":"Wilson","year":"2014","journal-title":"Transit. Met. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2706417","DOI":"10.1155\/2018\/2706417","article-title":"Isolation and identification of compounds from bioactive extracts of Taraxacum officinale Weber ex F. H. Wigg. (dandelion) as a potential source of antibacterial agents","volume":"2018","author":"Espinoza","year":"2018","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Olea, A.F., Espinoza, L., Sedan, C., Thomas, M., Mart\u00ednez, R., Mellado, M., Carrasco, H., and D\u00edaz, K. (2019). Synthesis and In Vitro Growth Inhibition of 2-Allylphenol Derivatives Against Phythopthora cinnamomi Rands. Molecules, 24.","DOI":"10.3390\/molecules24224196"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/pst.426","article-title":"Guidelines for accurate EC50\/IC50 estimation","volume":"10","author":"Sebaugh","year":"2011","journal-title":"Pharm. Stat."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Luczywo, A., Gonz\u00e1lez, L.G., Aguiar, A.C.C., de Souza, J.O., Souza, G.E., Oliva, G., Aguilar, L.F., Casal, J.J., Guido, R.V.C., and As\u00eds, S.E. (2021). 3-aryl-indolinones derivatives as antiplasmodial agents: Synthesis, biological activity and computational analysis. Nat. Prod. Res., 1\u20137.","DOI":"10.1080\/14786419.2021.1895149"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.1002\/slct.201901282","article-title":"Design, synthesis and docking calculations of prenylated chalcones as selective monoamine oxidase B inhibitors with antioxidant activity","volume":"4","author":"Mellado","year":"2019","journal-title":"ChemistrySelect"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"14733","DOI":"10.1073\/pnas.1614028114","article-title":"Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria","volume":"113","author":"Hall","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1128\/AAC.00144-13","article-title":"Crystal structures of bifunctional penicillin-binding protein 4 from Listeria monocytogenes","volume":"57","author":"Jeong","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.chembiol.2003.11.008","article-title":"Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase\/prodrug system","volume":"10","author":"Bennett","year":"2003","journal-title":"Chem. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jmb.2009.10.074","article-title":"Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB","volume":"395","author":"Ferraris","year":"2010","journal-title":"J. Mol. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1107\/S0907444906026746","article-title":"Structure of internalin C from Listeria monocytogenes","volume":"62","author":"Ooi","year":"2006","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"ref_45","unstructured":"(2010). The PyMOL Molecular Graphics System, LLC, Educational Licence. Version 2.0 Schr\u00f6dinger."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/jrs.6082","article-title":"Synthesis, characterization and surface enhanced Raman spectroscopy study of a new family of different substituted cruciform molecular systems deposited on gold nanoparticles","volume":"52","author":"Imbarack","year":"2021","journal-title":"J. Raman Spectrosc."},{"key":"ref_47","first-page":"287","article-title":"The complete N-alkylation of 1,4-diamino-2,5-dibromobenzene and of 1,4-diamino-2,5-dimethoxybenzene","volume":"1","author":"Doornbos","year":"1969","journal-title":"Org. Prep. Proced."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1021\/ac00127a005","article-title":"Selective detection of brominated aromatic compounds using gas chromatography\/negative chemical ionization mass spectrometry","volume":"58","author":"Buser","year":"1986","journal-title":"Anal. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1128\/JB.181.16.4725-4733.1999","article-title":"Structures of Gram-negative cell walls and their derived membrane vesicles","volume":"181","author":"Beveridge","year":"1999","journal-title":"J. Bacteriol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13756-019-0559-6","article-title":"Review on plant antimicrobials: A mechanistic viewpoint","volume":"8","author":"Khameneh","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ja.2007.38","article-title":"New aromatic nitro compounds from Salegentibacter sp. T436, an arctic sea ice bacterium: Taxonomy, fermentation, isolation and biological activities","volume":"60","author":"Schuhmann","year":"2007","journal-title":"J. Antibiot."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/kin.550230709","article-title":"Hydrolysis of schiff bases, 1: Kinetics and mechanism of spontaneous, acid, and base hydrolysis of N-(2\/4-hydroxybenzylidene)-2-aminobenzothiazoles","volume":"23","author":"Misra","year":"1991","journal-title":"Int. J. Chem. Kinet."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e5135","DOI":"10.7717\/peerj.5135","article-title":"The antimicrobial action of polyaniline involves production of oxidative stress while functionalisation of polyaniline introduces additional mechanisms","volume":"6","author":"Robertson","year":"2018","journal-title":"PeerJ"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fphar.2018.00102","article-title":"Resveratrol\u2014potential antibacterial agent against foodborne pathogens","volume":"9","author":"Ma","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.taap.2019.01.025","article-title":"Antibacterial activity of resveratrol structural analogues: A mechanistic evaluation of the structure-activity relationship","volume":"367","author":"Singh","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"19525","DOI":"10.1038\/s41598-019-55975-1","article-title":"Antimicrobial activity of resveratrol-derived monomers and dimers against foodborne pathogens","volume":"9","author":"Mattio","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1128\/MMBR.00039-06","article-title":"Listeria monocytogenes surface proteins: From genome predictions to function","volume":"71","author":"Bierne","year":"2007","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0092-8674(02)01136-4","article-title":"Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin","volume":"111","author":"Schubert","year":"2002","journal-title":"Cell"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/10\/8\/1483\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:55:13Z","timestamp":1760140513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/10\/8\/1483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":58,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["microorganisms10081483"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms10081483","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]}}}