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The cellular processes of uptake, trafficking and metabolic processing of host RBC proteins are thus crucial for the intraerythrocytic development of these parasites. In contrast to malarial Plasmodia, the molecular mechanisms of uptake and processing of the major RBC cytoplasmic protein hemoglobin remain widely unexplored in intraerythrocytic Babesia\/Theileria species. In the paper, we thus provide an updated comparison of the intraerythrocytic stage feeding mechanisms of these two distantly related groups of parasitic Apicomplexa. As the associated metabolic pathways including proteolytic degradation and networks facilitating heme homeostasis represent attractive targets for diverse antimalarials, and alterations in these pathways underpin several mechanisms of malaria drug resistance, our ambition is to highlight some fundamental differences resulting in different implications for parasite management with the potential for novel interventions against Babesia\/Theileria infections.<\/jats:p>","DOI":"10.3390\/microorganisms10081651","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T20:58:08Z","timestamp":1660597088000},"page":"1651","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Babesia, Theileria, Plasmodium and Hemoglobin"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9848-9435","authenticated-orcid":false,"given":"Daniel","family":"Sojka","sequence":"first","affiliation":[{"name":"Institute of Parasitology, Biology Centre, Academy of Sciences of the Czech Republic, Brani\u0161ovsk\u00e1 1160\/31, CZ-37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Jaloveck\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Biology Centre, Academy of Sciences of the Czech Republic, Brani\u0161ovsk\u00e1 1160\/31, CZ-37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"},{"name":"Faculty of Science, University of South Bohemia in \u010cesk\u00e9 Bud\u011bjovice, Brani\u0161ovsk\u00e1 1645\/31a, CZ-37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7719-4251","authenticated-orcid":false,"given":"Jan","family":"Perner","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Biology Centre, Academy of Sciences of the Czech Republic, Brani\u0161ovsk\u00e1 1160\/31, CZ-37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"ref_1","first-page":"3064","article-title":"Piroplasmids and ticks: A long-lasting intimate relationship","volume":"14","author":"Schnittger","year":"2009","journal-title":"Front. 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