{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:23:26Z","timestamp":1792027406550,"version":"4.4.0"},"reference-count":56,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Ministries of Education","award":["IP7\/01KI1725D"],"award-info":[{"award-number":["IP7\/01KI1725D"]}]},{"name":"German Federal Ministries of Education","award":["ZIM, ZF4117908 AJ8"],"award-info":[{"award-number":["ZIM, ZF4117908 AJ8"]}]},{"DOI":"10.13039\/501100006360","name":"Federal Ministry","doi-asserted-by":"publisher","award":["IP7\/01KI1725D"],"award-info":[{"award-number":["IP7\/01KI1725D"]}],"id":[{"id":"10.13039\/501100006360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006360","name":"Federal Ministry","doi-asserted-by":"publisher","award":["ZIM, ZF4117908 AJ8"],"award-info":[{"award-number":["ZIM, ZF4117908 AJ8"]}],"id":[{"id":"10.13039\/501100006360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Given that human Campylobacter jejuni infections are rising globally and antibiotic treatment is not recommended, infected patients would substantially benefit from alternative therapeutic strategies. Short-chain fatty acids such as butyrate are known for their health benefits, including anti-microbial and anti-inflammatory effects. This prompted us to investigate potential disease-alleviating properties of butyrate treatment during acute murine C. jejuni-induced enterocolitis. Therefore, following gut microbiota depletion IL-10\u2212\/\u2212 mice were challenged with 109 viable C. jejuni cells by oral gavage and treated with butyrate via the drinking water (22 g\/L) starting on day 2 post-infection. As early as day 3 post-infection, butyrate reduced diarrheal severity and frequency in treated mice, whereas on day 6 post-infection, gastrointestinal C. jejuni burdens and the overall clinical outcomes were comparable in butyrate- and placebo-treated cohorts. Most importantly, butyrate treatment dampened intestinal pro-inflammatory immune responses given lower colonic numbers of apoptotic cells and neutrophils, less distinct TNF-\u03b1 secretion in mesenteric lymph nodes and lower IL-6 and MCP-1 concentrations in the ileum. In conclusion, results of our preclinical intervention study provide evidence that butyrate represents a promising candidate molecule for the treatment of acute campylobacteriosis.<\/jats:p>","DOI":"10.3390\/microorganisms10101953","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T04:00:02Z","timestamp":1665288002000},"page":"1953","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Less Pronounced Immunopathological Responses Following Oral Butyrate Treatment of Campylobacter\u00a0jejuni-Infected Mice"],"prefix":"10.3390","volume":"10","author":[{"given":"Ke","family":"Du","sequence":"first","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minnja S.","family":"Foote","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Buczkowski","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany"},{"name":"Hofmann & Sommer GmbH und Co., KG, B\u00fcro Berlin, 12489 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany"},{"name":"Hofmann & Sommer GmbH und Co., KG, B\u00fcro Berlin, 12489 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bereswill","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-651X","authenticated-orcid":false,"given":"Markus M.","family":"Heimesaat","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Klein, G. (2017). Chapter 1\u2014Human campylobacteriosis. Campylobacter, Academic Press.","DOI":"10.1016\/B978-0-12-803623-5.00001-0"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1086\/513780","article-title":"Epidemiologic and clinical features of Campylobacter jejuni infections","volume":"176","author":"Blaser","year":"1997","journal-title":"J. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority, and European Centre for Disease Prevention and Control (2021). The European Union One Health 2020 Zoonoses Report. EFSA J., 19, e06971.","DOI":"10.2903\/j.efsa.2021.6971"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wilson, D.J., Gabriel, E., Leatherbarrow, A.J., Cheesbrough, J., Gee, S., Bolton, E., Fox, A., Fearnhead, P., Hart, C.A., and Diggle, P.J. (2008). Tracing the source of campylobacteriosis. PLoS Genet., 4.","DOI":"10.1371\/journal.pgen.1000203"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrmicro1718","article-title":"Campylobacter jejuni: Molecular biology and pathogenesis","volume":"5","author":"Young","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fmicb.2011.00200","article-title":"Campylobacter spp. as a Foodborne Pathogen: A Review","volume":"2","author":"Silva","year":"2011","journal-title":"Front. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/mi.2017.66","article-title":"Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon","volume":"11","author":"Krug","year":"2018","journal-title":"Mucosal Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Keithlin, J., Sargeant, J., Thomas, M.K., and Fazil, A. (2014). Systematic review and meta-analysis of the proportion of Campylobacter cases that develop chronic sequelae. BMC Public Health, 14.","DOI":"10.1186\/1471-2458-14-1203"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.micinf.2009.07.004","article-title":"Sialylation of Campylobacter jejuni lipo-oligosaccharides is associated with severe gastro-enteritis and reactive arthritis","volume":"11","author":"Mortensen","year":"2009","journal-title":"Microbes Infect."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kl\u00f8ve, S., Genger, C., Weschka, D., Mousavi, S., Bereswill, S., and Heimesaat, M.M. (2020). Toll-Like Receptor-4 Is Involved in Mediating Intestinal and Extra-Intestinal Inflammation in Campylobacter coli-Infected Secondary Abiotic IL-10\u2212\/\u2212 Mice. Microorganisms, 8.","DOI":"10.3390\/microorganisms8121882"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1056\/NEJM199305203282005","article-title":"Brief report: Shock and multiple-organ dysfunction after self-administration of Salmonella endotoxin","volume":"328","author":"Kaulbach","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Ellstr\u00f6m, P., Hansson, I., Nilsson, A., Rautelin, H., and Olsson Engvall, E. (2016). Lipooligosaccharide locus classes and putative virulence genes among chicken and human Campylobacter Jejuni isolates. BMC Microbiol., 16.","DOI":"10.1186\/s12866-016-0740-5"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1095\/biolreprod.106.056143","article-title":"Interleukin 10 Regulates Inflammatory Cytokine Synthesis to Protect Against Lipopolysaccharide-Induced Abortion and Fetal Growth Restriction in Mice1","volume":"76","author":"Robertson","year":"2007","journal-title":"Biol. Reprod."},{"key":"ref_14","first-page":"233","article-title":"Murine Models for the Investigation of Colonization Resistance and Innate Immune Responses in Campylobacter Jejuni Infections","volume":"431","author":"Mousavi","year":"2021","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Mousavi, S., Bereswill, S., and Heimesaat, M.M. (2020). Novel Clinical Campylobacter jejuni Infection Models Based on Sensitization of Mice to Lipooligosaccharide, a Major Bacterial Factor Triggering Innate Immune Responses in Human Campylobacteriosis. Microorganisms, 8.","DOI":"10.3390\/microorganisms8040482"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1038\/s41598-020-59890-8","article-title":"Vitamin C alleviates acute enterocolitis in Campylobacter jejuni infected mice","volume":"10","author":"Mousavi","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Lobo de S\u00e1, F.D., Backert, S., Nattramilarasu, P.K., Mousavi, S., Sandle, G.I., Bereswill, S., Heimesaat, M.M., Schulzke, J.D., and B\u00fccker, R. (2021). Vitamin D Reverses Disruption of Gut Epithelial Barrier Function Caused by Campylobacter jejuni. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168872"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13099-019-0343-4","article-title":"Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model","volume":"12","author":"Mousavi","year":"2020","journal-title":"Gut. Pathog."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mousavi, S., Weschka, D., Bereswill, S., and Heimesaat, M.M. (2020). Preclinical Evaluation of Oral Urolithin-A for the Treatment of Acute Campylobacteriosis in Campylobacter Jejuni Infected Microbiota-Depleted IL-10\u2212\/\u2212 Mice. Pathogens, 10.","DOI":"10.3390\/pathogens10010007"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Bereswill, S., Mousavi, S., Weschka, D., Buczkowski, A., Schmidt, S., and Heimesaat, M.M. (2021). Peroral Clove Essential Oil Treatment Ameliorates Acute Campylobacteriosis-Results from a Preclinical Murine Intervention Study. Microorganisms, 9.","DOI":"10.3390\/microorganisms9040735"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Heimesaat, M.M., Mousavi, S., Weschka, D., and Bereswill, S. (2021). Garlic Essential Oil as Promising Option for the Treatment of Acute Campylobacteriosis-Results from a Preclinical Placebo-Controlled Intervention Study. Microorganisms, 9.","DOI":"10.3390\/microorganisms9061140"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Heimesaat, M.M., Mousavi, S., Weschka, D., and Bereswill, S. (2021). Anti-Pathogenic and Immune-Modulatory Effects of Peroral Treatment with Cardamom Essential Oil in Acute Murine Campylobacteriosis. Microorganisms, 9.","DOI":"10.3390\/microorganisms9010169"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Mousavi, S., Weschka, D., Bereswill, S., and Heimesaat, M.M. (2021). Immune-Modulatory Effects upon Oral Application of Cumin-Essential-Oil to Mice Suffering from Acute Campylobacteriosis. Pathogens, 10.","DOI":"10.3390\/pathogens10070818"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Bereswill, S., Mousavi, S., Weschka, D., and Heimesaat, M.M. (2021). Disease-Alleviating Effects of Peroral Activated Charcoal Treatment in Acute Murine Campylobacteriosis. Microorganisms, 9.","DOI":"10.3390\/microorganisms9071424"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1556\/1886.2021.00001","article-title":"A literature survey on antimicrobial and immune-modulatory effects of butyrate revealing non-antibiotic approaches to tackle bacterial infections","volume":"11","author":"Du","year":"2021","journal-title":"Eur. J. Microbiol. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.1080\/10408398.2018.1542587","article-title":"Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria","volume":"59","author":"Fu","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1017\/S0954422410000247","article-title":"From the gut to the peripheral tissues: The multiple effects of butyrate","volume":"23","author":"Guilloteau","year":"2010","journal-title":"Nutr. Res. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pharmthera.2016.04.007","article-title":"Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis","volume":"164","author":"Sivaprakasam","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ebiom.2018.03.030","article-title":"Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model","volume":"30","author":"Chen","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2485s","DOI":"10.1093\/jn\/133.7.2485S","article-title":"Inhibition of histone deacetylase activity by butyrate","volume":"133","author":"Davie","year":"2003","journal-title":"J. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4161\/viru.23753","article-title":"Resistance mechanisms in Campylobacter jejuni","volume":"4","author":"Iovine","year":"2013","journal-title":"Virulence"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8785","DOI":"10.4049\/jimmunol.177.12.8785","article-title":"Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii","volume":"177","author":"Heimesaat","year":"2006","journal-title":"J. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Bereswill, S., Fischer, A., Plickert, R., Haag, L.M., Otto, B., K\u00fchl, A.A., Dasti, J.I., Zautner, A.E., Mu\u00f1oz, M., and Loddenkemper, C. (2011). Novel murine infection models provide deep insights into the \u201cm\u00e9nage \u00e0 trois\u201d of Campylobacter Jejuni, microbiota and host innate immunity. PLoS ONE, 6.","DOI":"10.1371\/annotation\/5247af81-4595-44b7-9c3f-2e45ad85abfa"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2017.12.023","article-title":"The octapetide NAP alleviates intestinal and extra-intestinal anti-inflammatory sequelae of acute experimental colitis","volume":"101","author":"Heimesaat","year":"2018","journal-title":"Peptides"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0009-8981(89)90231-3","article-title":"Pharmacokinetic study of butyric acid administered in vivo as sodium and arginine butyrate salts","volume":"181","author":"Daniel","year":"1989","journal-title":"Clin. Chim. Acta"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Huang, F.C., and Huang, S.C. (2021). The Combined Beneficial Effects of Postbiotic Butyrate on Active Vitamin D3-Orchestrated Innate Immunity to Salmonella Colitis. Biomedicines, 9.","DOI":"10.3390\/biomedicines9101296"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Beier, R.C., Byrd, J.A., Caldwell, D., Andrews, K., Crippen, T.L., Anderson, R.C., and Nisbet, D.J. (2019). Inhibition and Interactions of Campylobacter jejuni from Broiler Chicken Houses with Organic Acids. Microorganisms, 7.","DOI":"10.3390\/microorganisms7080223"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1128\/CVI.00267-06","article-title":"Effect of oral administration of Butyrivibrio fibrisolvens MDT-1 on experimental enterocolitis in mice","volume":"13","author":"Ohkawara","year":"2006","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3389\/fmicb.2016.01416","article-title":"The Probiotic Butyricicoccus pullicaecorum Reduces Feed Conversion and Protects from Potentially Harmful Intestinal Microorganisms and Necrotic Enteritis in Broilers","volume":"7","author":"Eeckhaut","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.2147\/JIR.S300989","article-title":"The Immunomodulatory Functions of Butyrate","volume":"14","author":"Siddiqui","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_43","first-page":"4000","article-title":"Sodium butyrate protects the intestinal barrier function in peritonitic mice","volume":"8","author":"Han","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2527\/jas.50965","article-title":"Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions","volume":"90","author":"Ma","year":"2012","journal-title":"J. Anim. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tmaid.2013.08.008","article-title":"Sodium butyrate and short chain fatty acids in prevention of travellers\u2019 diarrhoea: A randomized prospective study","volume":"12","author":"Krokowicz","year":"2014","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"fnx046","DOI":"10.1093\/femsle\/fnx046","article-title":"Effect of butyrate and Lactobacillus GG on a butyrate receptor and transporter during Campylobacter Jejuni exposure","volume":"364","author":"Cresci","year":"2017","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1177\/0271678X20910533","article-title":"Sodium butyrate attenuated neuronal apoptosis via GPR41\/G\u03b2\u03b3\/PI3K\/Akt pathway after MCAO in rats","volume":"41","author":"Zhou","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/bph.13637","article-title":"An orally administered butyrate-releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium-induced murine colitis","volume":"174","author":"Simeoli","year":"2017","journal-title":"Br. J. Pharm."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Food additives and Nutrient Sources added to Food (ANS) (2014). Scientific Opinion on the re-evaluation of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) as food additives. EFSA J., 12, 3779.","DOI":"10.2903\/j.efsa.2014.3779"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.4110\/in.2020.20.e15","article-title":"The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation","volume":"20","author":"Chen","year":"2020","journal-title":"Immune Netw."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1053\/j.gastro.2011.09.042","article-title":"Campylobacter jejuni induces colitis through activation of mammalian target of rapamycin signaling","volume":"142","author":"Sun","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.3945\/jn.115.218578","article-title":"Moderately Fermentable Potato Fiber Attenuates Signs and Inflammation Associated with Experimental Colitis in Mice","volume":"145","author":"Panasevich","year":"2015","journal-title":"J. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Peh, E., Kittler, S., Reich, F., and Kehrenberg, C. (2020). Antimicrobial activity of organic acids against Campylobacter spp. and development of combinations-A synergistic effect?. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0239312"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.molimm.2013.09.003","article-title":"Cyclic AMP synergizes with butyrate in promoting \u03b2-defensin 9 expression in chickens","volume":"57","author":"Sunkara","year":"2014","journal-title":"Mol. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"845","DOI":"10.5650\/jos.ess15035","article-title":"Synthesis and Characterization of a Novel Phenolic Lipid for Use as Potential Lipophilic Antioxidant and as a Prodrug of Butyric Acid","volume":"64","author":"Kaki","year":"2015","journal-title":"J. Oleo Sci."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ahmed, I., Yusuf, K., Roy, B.C., Stubbs, J., Anant, S., Attard, T.M., Sampath, V., and Umar, S. (2021). Dietary Interventions Ameliorate Infectious Colitis by Restoring the Microbiome and Promoting Stem Cell Proliferation in Mice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010339"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/10\/10\/1953\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:44:55Z","timestamp":1760143495000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/10\/10\/1953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":56,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["microorganisms10101953"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms10101953","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,30]]}}}