{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:46:18Z","timestamp":1783406778975,"version":"3.54.6"},"reference-count":134,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["406019\/2021-5"],"award-info":[{"award-number":["406019\/2021-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["309734\/2018-5"],"award-info":[{"award-number":["309734\/2018-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","award":["406019\/2021-5"],"award-info":[{"award-number":["406019\/2021-5"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","award":["309734\/2018-5"],"award-info":[{"award-number":["309734\/2018-5"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Ensino Superior","award":["406019\/2021-5"],"award-info":[{"award-number":["406019\/2021-5"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Ensino Superior","award":["309734\/2018-5"],"award-info":[{"award-number":["309734\/2018-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Eosinophils are remarkably recruited during schistosomiasis mansoni, one of the most common parasitic diseases worldwide. These cells actively migrate and accumulate at sites of granulomatous inflammation termed granulomas, the main pathological feature of this disease. Eosinophils colonize granulomas as a robust cell population and establish complex interactions with other immune cells and with the granuloma microenvironment. Eosinophils are the most abundant cells in granulomas induced by Schistosoma mansoni infection, but their functions during this disease remain unclear and even controversial. Here, we explore the current information on eosinophils as components of Schistosoma mansoni granulomas in both humans and natural and experimental models and their potential significance as central cells triggered by this infection.<\/jats:p>","DOI":"10.3390\/microorganisms10102022","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T22:21:11Z","timestamp":1665699671000},"page":"2022","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-2719","authenticated-orcid":false,"given":"K\u00e1ssia K.","family":"Malta","sequence":"first","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Juiz de Fora 36036-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthia","family":"Palazzi","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Juiz de Fora 36036-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5163-5714","authenticated-orcid":false,"given":"Vitor H.","family":"Neves","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Juiz de Fora 36036-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Juiz de Fora 36036-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-3015","authenticated-orcid":false,"given":"Thiago P.","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Juiz de Fora 36036-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1736-0806","authenticated-orcid":false,"given":"Rossana C. N.","family":"Melo","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Juiz de Fora 36036-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"Gryseels","year":"2006","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","article-title":"Schistosomiasis","volume":"4","author":"McManus","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/oxfordjournals.bmb.a011693","article-title":"Immunological aspects of human schistosomiasis","volume":"54","author":"Butterworth","year":"1998","journal-title":"Brit. Med. Bull."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1073\/pnas.87.1.61","article-title":"Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni","volume":"87","author":"Sher","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.4049\/jimmunol.135.3.2121","article-title":"Immune responses during human Schistosomiasis mansoni. XI. Immunologic status of patients with acute infections and after treatment","volume":"135","author":"Gazzinelli","year":"1985","journal-title":"J. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e00127-19","DOI":"10.1128\/IAI.00127-19","article-title":"Eosinophils and Macrophages within the Th2-Induced Granuloma: Balancing Killing and Healing in a Tight Space","volume":"87","author":"Ariyaratne","year":"2019","journal-title":"Infect. Immun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1111\/brv.12708","article-title":"Changing our view of the Schistosoma granuloma to an ecological standpoint","volume":"96","author":"Malta","year":"2021","journal-title":"Biol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.pt.2016.05.004","article-title":"Eosinophils in helminth infection: Defenders and dupes","volume":"32","author":"Huang","year":"2016","journal-title":"Trends Parasitol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0169-4758(99)01620-8","article-title":"The role of eosinophils in parasitic helminth infections: Insights from genetically modified mice","volume":"16","author":"Behm","year":"2000","journal-title":"Parasitol. Today"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1086\/324668","article-title":"Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni","volume":"185","author":"Silva","year":"2002","journal-title":"J. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/(SICI)1521-4141(199804)28:04<1408::AID-IMMU1408>3.0.CO;2-H","article-title":"Type 1 and type 2 cytokine-producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection","volume":"28","author":"Fallon","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1046\/j.1365-3024.1998.00150.x","article-title":"The immune response and immunopathology in infection with Schistosoma mansoni: A key role of major egg antigen Sm-p40","volume":"20","author":"Stadecker","year":"1998","journal-title":"Parasite Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1469-0691.2009.03131.x","article-title":"Acute schistosomiasis, a diagnostic and therapeutic challenge","volume":"16","author":"Paris","year":"2010","journal-title":"Clin. Microbiol. Inf."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.it.2022.06.005","article-title":"Type 2 immunity: A two-edged sword in schistosomiasis immunopathology","volume":"43","author":"Musaigwa","year":"2022","journal-title":"Trends Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4049\/jimmunol.146.4.1322","article-title":"Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni","volume":"146","author":"Grzych","year":"1991","journal-title":"J. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0167-5699(99)01551-0","article-title":"Immunopathology of schistosomiasis: A cautionary tale of mice and men","volume":"21","author":"Fallon","year":"2000","journal-title":"Immunol. Today"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.3389\/fimmu.2018.02492","article-title":"Schistosoma \u201cEggs-Iting\u201d the Host: Granuloma Formation and Egg Excretion","volume":"9","author":"Schwartz","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gobbi, F., Martelli, G., Attard, L., Buonfrate, D., Angheben, A., Marchese, V., Bortesi, L., Gobbo, M., Vanino, E., and Viale, P. (2015). Schistosoma mansoni Eggs in Spleen and Lungs, Mimicking Other Diseases. PLoS Negl. Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0003860"},{"key":"ref_19","first-page":"167","article-title":"Cor pulmonale in Manson\u2019s schistosomiasis. I. Frequency in necropsy material; pulmonary vascular changes caused by schistosome ova","volume":"30","year":"1954","journal-title":"Am. J. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1590\/0037-8682-0087-2017","article-title":"Ectopic forms of schistosomiasis mansoni in the second macroregion of Alagoas: Case series report and review of the literature","volume":"50","author":"Lima","year":"2017","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1007\/s00381-021-05267-9","article-title":"Medullary neuroschistosomiasis in adolescence: Case report and literature review","volume":"37","author":"Dastoli","year":"2021","journal-title":"Childs. Nerv. Syst."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1136\/jnnp.2005.078014","article-title":"Brain involvement in a Schistosoma mansoni myelopathy patient","volume":"77","author":"Artal","year":"2006","journal-title":"J. Neur. Neurosur. Psych."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"van der Vlugt, L.E.P.M., Labuda, L.A., Ozir-Fazalalikhan, A., Lievers, E., Gloudemans, A.K., Liu, K.Y., Barr, T.A., Sparwasser, T., Boon, L., and Ngoa, U.A. (2012). Schistosomes induce regulatory features in human and mouse CD1dhi B cells: Inhibition of allergic inflammation by IL-10 and regulatory T cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030883"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1093\/infdis\/jiu257","article-title":"Interleukin 10 (IL-10)\u2013producing CD1dhi regulatory B cells from Schistosoma haematobium\u2013infected individuals induce IL-10\u2013positive T cells and suppress effector T-cell cytokines","volume":"210","author":"Zinsou","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Turner, J.D., Jenkins, G.R., Hogg, K.G., Aynsley, S.A., Paveley, R.A., Cook, P.C., Coles, M.C., and Mountford, A.P. (2011). CD4+ CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection. PLoS Negl. Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0001269"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.4049\/jimmunol.172.5.3157","article-title":"The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells","volume":"172","author":"Hesse","year":"2004","journal-title":"J. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.pt.2013.12.009","article-title":"Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology","volume":"30","author":"Chuah","year":"2014","journal-title":"Trends Parasitol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Amaral, K.B., Silva, T.P., Dias, F.F., Malta, K.K., Rosa, F.M., Costa-Neto, S.F., Gentile, R., and Melo, R.C.N. (2017). Histological assessment of granulomas in natural and experimental Schistosoma mansoni infections using whole slide imaging. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184696"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3389\/fimmu.2013.00089","article-title":"The schistosoma granuloma: Friend or foe?","volume":"4","author":"Hams","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1146\/annurev-immunol-032712-100022","article-title":"The formation and function of granulomas","volume":"36","author":"Ramakrishnan","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e12778","DOI":"10.1111\/pim.12778","article-title":"Granuloma formation and tissue pathology in Schistosoma japonicum versus Schistosoma mansoni infections","volume":"43","author":"Llanwarne","year":"2021","journal-title":"Parasite Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1590\/S0074-02761998000700020","article-title":"Histoarchitecture of schistosomal granuloma development and involution: Morphogenetic and biomechanical approaches","volume":"93","author":"Lenzi","year":"1998","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1590\/S0074-02762006000900034","article-title":"Four whole-istic aspects of schistosome granuloma biology: Fractal arrangement, internal regulation, autopoietic component and closure","volume":"101","author":"Lenzi","year":"2006","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1046\/j.1365-3156.1998.00285.x","article-title":"Sonographic prediction of variceal bleeding in patients with liver fibrosis due to Schistosoma mansoni","volume":"3","author":"Richter","year":"1998","journal-title":"Trop. Med. Inter. Health"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-3024.2009.01157.x","article-title":"Schistosomiasis and liver fibrosis","volume":"31","author":"Andrade","year":"2009","journal-title":"Parasite Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.3389\/fimmu.2018.03019","article-title":"Identification of piecemeal degranulation and vesicular transport of MBP-1 in liver-infiltrating mouse eosinophils during acute experimental Schistosoma mansoni infection","volume":"9","author":"Dias","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.actatropica.2008.05.027","article-title":"Human schistosomiasis mansoni: Immune responses during acute and chronic phases of the infection","volume":"108","author":"Caldas","year":"2008","journal-title":"Acta Tropi."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1590\/S0074-02762010000400012","article-title":"Acute schistosomiasis mansoni: Revisited and reconsidered","volume":"105","author":"Lambertucci","year":"2010","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00281-021-00870-z","article-title":"Eosinophils and helminth infection: Protective or pathogenic? Springer Berlin Heidelberg","volume":"43","author":"Mitre","year":"2021","journal-title":"Semminars Immunopathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1084\/jem.142.3.560","article-title":"Antieosinophil serum and the kinetics of eosinophilia in Schistosomiasis mansoni","volume":"142","author":"Mahmoud","year":"1975","journal-title":"J. Exp. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0014-4894(79)90076-6","article-title":"Schistosoma mansoni: Peripheral and tissue eosinophilia in infected rats","volume":"47","author":"Knopf","year":"1979","journal-title":"Exp. Parasitol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1126\/science.2787531","article-title":"Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice","volume":"245","author":"Coffman","year":"1989","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1084\/jem.172.5.1425","article-title":"Eosinophilia in transgenic mice expressing interleukin 5","volume":"172","author":"Dent","year":"1990","journal-title":"J. Exp. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1074-7613(00)80294-0","article-title":"IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses","volume":"4","author":"Kopf","year":"1996","journal-title":"Immunity"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/infdis\/145.2.613","article-title":"The ecology of eosinophils in schistosomiasis","volume":"145","author":"Mahmoud","year":"1982","journal-title":"J. Infect. Dis."},{"key":"ref_46","first-page":"480","article-title":"Hepatic eosinophil granulocytopoiesis in murine experimental Schistosomiasis mansoni","volume":"62","author":"Borojevic","year":"1981","journal-title":"Brit. J. Exp. Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1590\/S0074-02761997000800005","article-title":"Immunological system and Schistosoma mansoni: Co-evolutionary immunobiology. What is the eosinophil role in parasite-host relationship?","volume":"92","author":"Lenzi","year":"1997","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1182\/blood-2006-04-015933","article-title":"Schistosoma mansoni infection in eosinophil lineage\u2013ablated mice","volume":"108","author":"Swartz","year":"2006","journal-title":"Blood"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"906338","DOI":"10.3389\/fimmu.2022.906338","article-title":"Dynamics of host immune response development during Schistosoma mansoni infection","volume":"13","author":"Costain","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.4049\/jimmunol.181.6.4004","article-title":"Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow","volume":"181","author":"Dyer","year":"2008","journal-title":"J. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"836755","DOI":"10.3389\/fcell.2022.836755","article-title":"Mitochondrial Population in Mouse Eosinophils: Ultrastructural Dynamics in Cell Differentiation and Inflammatory Diseases","volume":"10","author":"Bonjour","year":"2022","journal-title":"Front. Cell Dev. Bio."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13071-021-04655-z","article-title":"Evaluation of microscopy, serology, circulating anodic antigen (CAA), and eosinophil counts for the follow-up of migrants with chronic schistosomiasis: A prospective cohort study","volume":"14","author":"Tamarozzi","year":"2021","journal-title":"Parasit. Vectors"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e18481","DOI":"10.1097\/MD.0000000000018481","article-title":"Chronic schistosomiasis in African immigrants in Israel: Lessons for the non-endemic setting","volume":"98","author":"Paran","year":"2019","journal-title":"Medicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/path.1711210107","article-title":"The Schistosoma mansoni egg granuloma: Quantitation of cell populations","volume":"121","author":"Moore","year":"1977","journal-title":"J. Pathol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Melo, R.C.N., Dvorak, A.M., and Weller, P.F. (2022). Eosinophil-associated diseases (EADs). Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology, Academic Press.","DOI":"10.1016\/B978-0-12-813755-0.00008-3"},{"key":"ref_56","first-page":"389","article-title":"Localization of eosinophil major basic protein onto eggs of Schistosoma mansoni in human pathologic tissue","volume":"133","author":"Kephart","year":"1988","journal-title":"Am. J. Pathol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Thorne, K.J., and Mazza, G. (1991). Eosinophilia, activated eosinophils and human schistosomiasis. J. Cell. Sci.","DOI":"10.1242\/jcs.98.3.265"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/j.1600-0560.2008.01045.x","article-title":"Mucocutaneous Splendore-Hoeppli phenomenon","volume":"35","author":"Hussein","year":"2008","journal-title":"J. Cutane. Pathol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jlb.62.5.667","article-title":"Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils","volume":"62","author":"White","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.actatropica.2008.04.016","article-title":"The role of chemokines in controlling granulomatous inflammation in Schistosoma mansoni infection","volume":"108","author":"Souza","year":"2008","journal-title":"Acta Tropi."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0002-9440(10)63381-0","article-title":"Role of CCR4 ligands, CCL17 and CCL22, during Schistosoma mansoni egg-induced pulmonary granuloma formation in mice","volume":"165","author":"Jakubzick","year":"2004","journal-title":"Am. J. Pathol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1365-3024.2006.00896.x","article-title":"Serum and cerebral spinal fluid levels of chemokines and Th2 cytokines in Schistosoma mansoni myeloradiculopathy","volume":"28","author":"Teixeira","year":"2006","journal-title":"Parasite Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1590\/S0074-02762010000400006","article-title":"Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni","volume":"105","author":"Ferraz","year":"2010","journal-title":"Mem. Ins. Oswaldo Cruz"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/nri.2017.95","article-title":"Functions of tissue-resident eosinophils","volume":"17","author":"Weller","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.4049\/jimmunol.123.5.2220","article-title":"In vitro killing of S. mansoni schistosomula by eosinophils from infected rats: Role of cytophilic antibodies","volume":"123","author":"Capron","year":"1979","journal-title":"J. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1084\/jem.150.6.1456","article-title":"Interactions between human eosinophils and schistosomula of Schistosoma mansoni. II. The mechanism of irreversible eosinophil adherence","volume":"150","author":"Butterworth","year":"1979","journal-title":"J. Exp. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"C623","DOI":"10.1152\/ajpcell.1998.275.3.C623","article-title":"The mechanism of IL-5 signal transduction","volume":"275","author":"Adachi","year":"1998","journal-title":"Am. J. Physio. Cell. Physio."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1189\/jlb.69.3.353","article-title":"Eosinophil recruitment into sites of delayed-type hypersensitivity reactions in mice","volume":"69","author":"Teixeira","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.3347\/kjp.2009.47.S.S125","article-title":"Eosinophil-mediated tissue inflammatory responses in helminth infection","volume":"47","author":"Shin","year":"2009","journal-title":"Kor. J. Parasitol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1038\/s41467-018-06316-9","article-title":"Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge","volume":"9","author":"Yi","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1590\/S0037-86822008000200008","article-title":"A distribui\u00e7\u00e3o dos eosin\u00f3filos nas diferentes fases de evolu\u00e7\u00e3o do granuloma hep\u00e1tico em camundongos infectados pelo Schistosoma mansoni","volume":"41","author":"Lins","year":"2008","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Carvalho, O.S., Coelho, P.M.Z., and Lenzi, H. (2008). Patologia experimental com enfoque no granuloma esquistossom\u00f3tico. Schistosoma Mansoni & Esquistossomose: Uma Vis\u00e3o Multidisciplinary, L. Fiocruz.","DOI":"10.7476\/9788575413708"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0248-4900(91)90055-R","article-title":"Eosinophil granulocytopoiesis in hepatic periovular granulomas during the chronic phase of experimental murine Schistosomiasis mansoni","volume":"71","author":"Geuskens","year":"1991","journal-title":"Biol. Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1590\/S0074-02761995000200008","article-title":"Extramedullary hematopoiesis in murine schistosomiasis mansoni","volume":"90","author":"Lenzi","year":"1995","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Francisco, J.S., Terra, M.A.B.L., Klein, G.C.T., Dias de Oliveira, B.C.E.P., and Pelajo Machado, M. (2022). The Hepatic Extramedullary Hematopoiesis during Experimental Murine Schistosomiasis. Front. Immunol., 4861.","DOI":"10.3389\/fimmu.2022.955034"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0923-2494(97)82666-1","article-title":"Haematopoietic capacity of colony-forming cells mobilized in hepatic inflammatory reactions as compared to that of normal bone marrow cells","volume":"148","author":"Dutra","year":"1997","journal-title":"Res. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/intimm\/11.4.509","article-title":"Extramedullar B lymphopoiesis in liver schistosomal granulomas: Presence of the early stages and inhibition of the full B cell differentiation","volume":"11","author":"Rossi","year":"1999","journal-title":"Int. Immuol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Melo, R.C.N., Dvorak, A.M., and Weller, P.F. (2022). Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology, Academic Press.","DOI":"10.1016\/B978-0-12-813755-0.00002-2"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1084\/jem.177.6.1551","article-title":"The role of macrophage inflammatory protein 1 alpha in Schistosoma mansoni egg-induced granulomatous inflammation","volume":"177","author":"Lukacs","year":"1993","journal-title":"J. Exp. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1128\/IAI.73.4.2515-2523.2005","article-title":"Potential role of the chemokine macrophage inflammatory protein 1\u03b1 in human and experimental schistosomiasis","volume":"73","author":"Souza","year":"2005","journal-title":"Inf. Immunity"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1096\/fj.08-124248","article-title":"Macrophage migration inhibitory factor is critical to interleukin-5-driven eosinophilopoiesis and tissue eosinophilia triggered by Schistosoma mansoni infection","volume":"23","author":"Magalhaes","year":"2009","journal-title":"FASEB J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.imlet.2018.11.011","article-title":"Interaction and involvement of cellular adhesion molecules in the pathogenesis of Schistosomiasis mansoni","volume":"206","year":"2019","journal-title":"Immunol. Lett."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3389\/fimmu.2014.00496","article-title":"Eosinophil secretion of granule-derived cytokines","volume":"5","author":"Spencer","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_84","first-page":"1341","article-title":"Piecemeal degranulation in human eosinophils: A distinct secretion mechanism underlying inflammatory responses","volume":"25","author":"Melo","year":"2010","journal-title":"Histo. Hitopathol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/JLB.3MR1217-476R","article-title":"Contemporary understanding of the secretory granules in human eosinophils","volume":"104","author":"Melo","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1189\/jlb.0707503","article-title":"Mechanisms of eosinophil secretion: Large vesiculotubular carriers mediate transport and release of granule-derived cytokines and other proteins","volume":"83","author":"Melo","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.yexcr.2016.08.016","article-title":"Vesicular trafficking of immune mediators in human eosinophils revealed by immunoelectron microscopy","volume":"347","author":"Melo","year":"2016","journal-title":"Exp. Cell. Res."},{"key":"ref_88","first-page":"433","article-title":"Eosinophils favor the passage of eggs to the intestinal lumen in schistosomiasis","volume":"20","author":"Lenzi","year":"1987","journal-title":"Braz. J. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7048","DOI":"10.4049\/jimmunol.151.12.7048","article-title":"Granuloma eosinophils enhance IL-5 production by lymphocytes from mice infected with Schistosoma mansoni","volume":"151","author":"Metwali","year":"1993","journal-title":"J. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.4049\/jimmunol.162.2.1003","article-title":"Activated eosinophils are the major source of Th2-associated cytokines in the schistosome granuloma","volume":"162","author":"Rumbley","year":"1999","journal-title":"J. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.3389\/fmicb.2020.01973","article-title":"Monocyte and macrophage-mediated pathology and protective immunity during schistosomiasis","volume":"11","author":"Souza","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1128\/IAI.74.3.1471-1479.2006","article-title":"Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity","volume":"74","author":"Reiman","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1590\/S0074-02761987000800011","article-title":"In vivo kinetics of eosinophils and mast cells in experimental murine schistosomiasis","volume":"82","author":"Lenzi","year":"1987","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.4049\/jimmunol.121.6.2518","article-title":"Rat mast cell-eosinophil interaction in antibody-dependent eosinophil cytotoxicity to Schistosoma mansoni schistosomula","volume":"121","author":"Capron","year":"1978","journal-title":"J. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0035-9203(80)90272-2","article-title":"Schistosomes and eosinophils","volume":"74","author":"Capron","year":"1980","journal-title":"Trans. Roy. Soc. Trop. Med. Hygie."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e12916","DOI":"10.1111\/pim.12916","article-title":"Neutrophils and schistosomiasis: A missing piece in pathology","volume":"44","author":"Sanches","year":"2022","journal-title":"Parasite Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/pim.12336","article-title":"Human eosinophils modulate peripheral blood mononuclear cell response to Schistosoma mansoni adult worm antigen in vitro","volume":"38","author":"Tweyongyere","year":"2016","journal-title":"Parasite Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1186\/s13071-015-1197-3","article-title":"Hepatic myofibroblasts derived from Schistosoma mansoni-infected mice are a source of IL-5 and eotaxin: Controls of eosinophil populations in vitro","volume":"8","author":"Paiva","year":"2015","journal-title":"Parasite Vectors"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1084\/jem.20130071","article-title":"IL-9\u2013mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation","volume":"210","author":"Turner","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00441-010-1049-6","article-title":"Eosinophils in innate immunity: An evolving story","volume":"343","author":"Shamri","year":"2011","journal-title":"Cell Tissue Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ni.1981","article-title":"Eosinophils are required for the maintenance of plasma cells in the bone marrow","volume":"12","author":"Chu","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"9914","DOI":"10.1073\/pnas.1304046110","article-title":"Eosinophils secrete IL-4 to facilitate liver regeneration","volume":"110","author":"Goh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_103","first-page":"359","article-title":"Eosinophil-mediated destruction of Schistosoma mansoni eggs","volume":"20","author":"James","year":"1976","journal-title":"J. Reticulo. Soc."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1017\/S0022149X00700794","article-title":"Rodents as reservoir hosts in the transmission of Schistosoma mansoni in Richard-Toll, Senegal, West Africa","volume":"74","author":"Duplantier","year":"2000","journal-title":"J. Helminthol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/infdis\/jiy029","article-title":"Rodents as natural hosts of zoonotic Schistosoma species and hybrids: An epidemiological and evolutionary perspective from West Africa","volume":"218","author":"Catalano","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref_106","first-page":"10","article-title":"Assessing the nonhuman primate reservoir of Schistosoma mansoni in Africa: A systematic review","volume":"8","author":"Richards","year":"2019","journal-title":"Infect. Dis. Pov."},{"key":"ref_107","first-page":"13","article-title":"Non-human vertebrate hosts of Schistosoma mansoni and schistosomiasis transmission in Brazil","volume":"53","author":"Rey","year":"1993","journal-title":"Res. Rev. Parasitol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13071-016-1369-9","article-title":"Do schistosome vaccine trials in mice have an intrinsic flaw that generates spurious protection data?","volume":"9","author":"Wilson","year":"2016","journal-title":"Parasite Vectors"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1590\/S0036-46651984000600004","article-title":"Holochilus brasiliensis nanus Thomas, 1897: As an experimental model for filariasis, leishmaniasis and schistosomiasis","volume":"26","author":"Bastos","year":"1984","journal-title":"Rev. Inst. Med. Trop."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Morand, S., Krasnov, B.R., and Poulin, R. (2006). Rodents as definitive hosts of Schistosoma, with special reference to S. mansoni transmission. Micromammals and Macroparasites, Springer.","DOI":"10.1007\/978-4-431-36025-4"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1017\/S0031182000061734","article-title":"Long-term dynamics of natural populations of Schistosoma mansoni among Rattus rattus in patchy environment","volume":"104","author":"Pointier","year":"1992","journal-title":"Parasitology"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0001-706X(97)00068-5","article-title":"Natural Schistosoma mansoni infection in wild rats from Guadeloupe: Parasitological and immunological aspects","volume":"68","author":"Pointier","year":"1997","journal-title":"Acta Tropi."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1515\/helm-2017-0013","article-title":"Research Note. The wild water-rats and their relevance in the context of schistosomiasis mansoni in Brazil: What we know and recommendations for further research","volume":"54","author":"Miranda","year":"2017","journal-title":"Helminthologia"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1590\/S0074-02761992000800040","article-title":"Holochilus brasiliensis and Nectomys squamipes (Rodentia-Cricetidae) natural hosts of Schistosoma mansoni","volume":"87","author":"Picot","year":"1992","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Rokni, M.B. (2012). The Role of Wild Rodents in the Transmission of Schistosoma mansoni in Brazil. Schistosomiasis, IntechOpen.","DOI":"10.5772\/1309"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"932","DOI":"10.2478\/s11686-019-00096-y","article-title":"Spatial and seasonal distribution of Holochilus sciureus with Schistosoma mansoni infection in an endemic area for schistosomiasis in Brazil","volume":"64","author":"Rodrigues","year":"2019","journal-title":"Acta Parasit."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/JLB.1MR1117-442RR","article-title":"Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease","volume":"104","author":"Coden","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"ref_118","first-page":"1","article-title":"Alterations in blood glucose concentration in wild rodents, Holochilus sciureus, naturally infected with Schistosoma mansoni","volume":"31","author":"Rodrigues","year":"2022","journal-title":"Rev. Braz. Parasitol. Vet."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4236\/ojas.2019.92015","article-title":"Schistosoma mansoni infection in Holochilus sciureus shows sex-related differences in parasitological patterns","volume":"9","author":"Miranda","year":"2019","journal-title":"Open J. Anim. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1590\/S1984-29612013000400011","article-title":"Biochemical and histological changes in liver of Nectomys squamipes naturally infected by Schistosoma mansoni","volume":"22","author":"Alves","year":"2013","journal-title":"Rev. Braz. Parasitol. Vet."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1590\/s1984-29612019075","article-title":"Parasitological and histological aspects of Holochilus sciureus naturally infected by Schistosoma mansoni","volume":"28","author":"Silva","year":"2019","journal-title":"Rev. Braz. Parasitol. Vet."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1590\/S0074-02762002000900026","article-title":"Natural Schistosoma mansoni infection in Nectomys squamipes: Histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H\/He mice","volume":"97","author":"Hulstijn","year":"2002","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1590\/S0074-02761995000200034","article-title":"Calomys callosus: An alternative model to study fibrosis in Schistosomiasis mansoni: The pathology of the acute phase","volume":"90","author":"Lenzi","year":"1995","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1590\/S0074-02761992000500051","article-title":"Natural infection of wild rodents by Schistosoma mansoni parasitological aspects","volume":"87","author":"Silva","year":"1992","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1590\/S0074-02762002000900003","article-title":"Experimental evidence and ecological perspectives for the adaptation of Schistosoma mansoni Sambon, 1907 (Digenea: Schistosomatidae) to a wild host, the water-rat, Nectomys squamipes Brants, 1827 (Rodentia: Sigmodontinae)","volume":"97","author":"Fernandes","year":"2002","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/00034983.1980.11687328","article-title":"Eosinophils as effector cells in the destruction of Schistosoma mansoni eggs in granulomas","volume":"74","author":"Mitros","year":"1980","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.4049\/jimmunol.142.12.4422","article-title":"Functional role of human IgG subclasses in eosinophil-mediated killing of schistosomula of Schistosoma mansoni","volume":"142","author":"Khalife","year":"1989","journal-title":"J. Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1084\/jem.147.1.147","article-title":"Complement-mediated killing of schistosomula of Schistosoma mansoni by rat eosinophils in vitro","volume":"147","author":"McLaren","year":"1978","journal-title":"J. Exp. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev-pathmechdis-012419-032756","article-title":"Contributions of eosinophils to human health and disease","volume":"15","author":"Klion","year":"2020","journal-title":"Ann. Rev. Pathol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.jaci.2007.03.043","article-title":"Eosinophils: Singularly destructive effector cells or purveyors of immunoregulation?","volume":"119","author":"Jacobsen","year":"2007","journal-title":"J. Alle. Clin. Immunol."},{"key":"ref_131","first-page":"9","article-title":"Eosinophils: Changing perspectives in health and disease","volume":"13","author":"Rosenberg","year":"2013","journal-title":"Nat. Rev."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"155701","DOI":"10.1016\/j.cyto.2021.155701","article-title":"Eosinophils participate in modulation of liver immune response and tissue damage induced by Schistosoma mansoni infection in mice","volume":"149","author":"Rodrigues","year":"2022","journal-title":"Cytokine"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.3389\/fimmu.2019.01010","article-title":"Schistosoma mansoni-derived lipids in extracellular vesicles: Potential agonists for eosinophillic tissue repair","volume":"10","author":"Coakley","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Masterson, J.C., Menard-Katcher, C., Larsen, L.D., Furuta, G.T., and Spencer, L.A. (2021). Heterogeneity of intestinal tissue eosinophils: Potential considerations for next-generation eosinophil-targeting strategies. Cells, 10.","DOI":"10.3390\/cells10020426"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/10\/10\/2022\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:53:15Z","timestamp":1760143995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/10\/10\/2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,13]]},"references-count":134,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["microorganisms10102022"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms10102022","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,13]]}}}