{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:13:07Z","timestamp":1788469987377,"version":"build-2803163510"},"reference-count":235,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"National Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["2020-04302"],"award-info":[{"award-number":["2020-04302"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Puberty is a critical period of development marked by the maturation of the central nervous system, immune system, and hypothalamic\u2013pituitary\u2013adrenal axis. Due to the maturation of these fundamental systems, this is a period of development that is particularly sensitive to stressors, increasing susceptibility to neurodevelopmental and neurodegenerative disorders later in life. The gut microbiome plays a critical role in the regulation of stress and immune responses, and gut dysbiosis has been implicated in the development of neurodevelopmental and neurodegenerative disorders. The purpose of this review is to summarize the current knowledge about puberty, neurodegeneration, and the gut microbiome. We also examine the consequences of pubertal exposure to stress and gut dysbiosis on the development of neurodevelopmental and neurodegenerative disorders. Understanding how alterations to the gut microbiome, particularly during critical periods of development (i.e., puberty), influence the pathogenesis of these disorders may allow for the development of therapeutic strategies to prevent them.<\/jats:p>","DOI":"10.3390\/microorganisms10112163","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T07:06:46Z","timestamp":1667200006000},"page":"2163","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Linking Puberty and the Gut Microbiome to the Pathogenesis of Neurodegenerative Disorders"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3921-712X","authenticated-orcid":false,"given":"Pasquale","family":"Esposito","sequence":"first","affiliation":[{"name":"NISE Laboratory, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-0217","authenticated-orcid":false,"given":"Nafissa","family":"Ismail","sequence":"additional","affiliation":[{"name":"NISE Laboratory, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada"},{"name":"Brain and Mind Research Institute, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.neubiorev.2016.05.035","article-title":"Immunoadolescence: Neuroimmune Development and Adolescent Behavior","volume":"70","author":"Brenhouse","year":"2016","journal-title":"Neurosci. 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