{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:59:39Z","timestamp":1789642779736,"version":"4.0.0"},"reference-count":90,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Postgraduate Research &amp; Practice Innovation Program of Jiangsu Province","award":["SJCX21_1633"],"award-info":[{"award-number":["SJCX21_1633"]}]},{"name":"the Postgraduate Research &amp; Practice Innovation Program of Jiangsu Province","award":["KYCX22_3540"],"award-info":[{"award-number":["KYCX22_3540"]}]},{"name":"the Postgraduate Research &amp; Practice Innovation Program of Jiangsu Province","award":["[JBGS (2021)111]"],"award-info":[{"award-number":["[JBGS (2021)111]"]}]},{"name":"the Postgraduate Research &amp; Practice Innovation Program of Jiangsu Province","award":["(G2022014150L)"],"award-info":[{"award-number":["(G2022014150L)"]}]},{"name":"the International Collaboration Program from Science and Technology Agency of Jiangsu Province (2019)","award":["SJCX21_1633"],"award-info":[{"award-number":["SJCX21_1633"]}]},{"name":"the International Collaboration Program from Science and Technology Agency of Jiangsu Province (2019)","award":["KYCX22_3540"],"award-info":[{"award-number":["KYCX22_3540"]}]},{"name":"the International Collaboration Program from Science and Technology Agency of Jiangsu Province (2019)","award":["[JBGS (2021)111]"],"award-info":[{"award-number":["[JBGS (2021)111]"]}]},{"name":"the International Collaboration Program from Science and Technology Agency of Jiangsu Province (2019)","award":["(G2022014150L)"],"award-info":[{"award-number":["(G2022014150L)"]}]},{"name":"High End Talent Program for International Collaboration","award":["SJCX21_1633"],"award-info":[{"award-number":["SJCX21_1633"]}]},{"name":"High End Talent Program for International Collaboration","award":["KYCX22_3540"],"award-info":[{"award-number":["KYCX22_3540"]}]},{"name":"High End Talent Program for International Collaboration","award":["[JBGS (2021)111]"],"award-info":[{"award-number":["[JBGS (2021)111]"]}]},{"name":"High End Talent Program for International Collaboration","award":["(G2022014150L)"],"award-info":[{"award-number":["(G2022014150L)"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","award":["SJCX21_1633"],"award-info":[{"award-number":["SJCX21_1633"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","award":["KYCX22_3540"],"award-info":[{"award-number":["KYCX22_3540"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","award":["[JBGS (2021)111]"],"award-info":[{"award-number":["[JBGS (2021)111]"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","award":["(G2022014150L)"],"award-info":[{"award-number":["(G2022014150L)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Salmonella is a foodborne pathogen that causes enterogastritis among humans, livestock and poultry, and it not only causes huge economic losses for the feed industry but also endangers public health around the world. However, the prevention and treatment of Salmonella infection has remained poorly developed because of its antibiotic resistance. Bacterial quorum sensing (QS) system is an intercellular cell\u2013cell communication mechanism involving multiple cellular processes, especially bacterial virulence, such as biofilm formation, motility, adherence, and invasion. Therefore, blocking the QS system may be a new strategy for Salmonella infection independent of antibiotic treatment. Here, we have reviewed the central role of the QS system in virulence regulation of Salmonella and summarized the most recent advances about quorum quenching (QQ) in virulence attenuation during Salmonella infection. Unraveling the complex relationship between QS and bacterial virulence may provide new insight into the therapy of pathogen infection.<\/jats:p>","DOI":"10.3390\/microorganisms10112211","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T02:44:32Z","timestamp":1667961872000},"page":"2211","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Regulatory Mechanisms between Quorum Sensing and Virulence in Salmonella"],"prefix":"10.3390","volume":"10","author":[{"given":"Xiaojie","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Joint Laboratory of International Cooperation on Prevention and Control Technology of Important Animal Diseases and Zoonoses of Jiangsu Higher Education Institutions, Yangzhou University, Yangzhou 225009, China"},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baobao","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Joint Laboratory of International Cooperation on Prevention and Control Technology of Important Animal Diseases and Zoonoses of Jiangsu Higher Education Institutions, Yangzhou University, Yangzhou 225009, China"},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Joint Laboratory of International Cooperation on Prevention and Control Technology of Important Animal Diseases and Zoonoses of Jiangsu Higher Education Institutions, Yangzhou University, Yangzhou 225009, China"},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Bin","sequence":"additional","affiliation":[{"name":"Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Joint Laboratory of International Cooperation on Prevention and Control Technology of Important Animal Diseases and Zoonoses of Jiangsu Higher Education Institutions, Yangzhou University, Yangzhou 225009, China"},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-8841","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Joint Laboratory of International Cooperation on Prevention and Control Technology of Important Animal Diseases and Zoonoses of Jiangsu Higher Education Institutions, Yangzhou University, Yangzhou 225009, China"},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Joint Laboratory of International Cooperation on Prevention and Control Technology of Important Animal Diseases and Zoonoses of Jiangsu Higher Education Institutions, Yangzhou University, Yangzhou 225009, China"},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority, and European Centre for Disease Prevention and Control (2019). 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