{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:35:11Z","timestamp":1788010511922,"version":"build-2784847793"},"reference-count":42,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Romanian National Authority for Scientific Research, CNDI-UEFISCDI","award":["110\/2012"],"award-info":[{"award-number":["110\/2012"]}]},{"name":"Romanian National Authority for Scientific Research, CNDI-UEFISCDI","award":["24868\/5.11.2021"],"award-info":[{"award-number":["24868\/5.11.2021"]}]},{"name":"UASVM Cluj-Napoca","award":["110\/2012"],"award-info":[{"award-number":["110\/2012"]}]},{"name":"UASVM Cluj-Napoca","award":["24868\/5.11.2021"],"award-info":[{"award-number":["24868\/5.11.2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>(1) Background: Various studies on artemisinin and its derivatives have shown that Artemisia annua may be of therapeutic interest for different diseases, including chicken coccidiosis. This study aimed to evaluate the effects of Artemisia annua on farm-reared broiler chickens by analyzing both the anticoccidial efficacy and its effect on the intestinal microbiota of poultry. (2) Methods: The experiment was performed within three houses on a broiler chicken farm located in Romania. House 1 was the experimental group and received a diet with an addition of A. annua. Houses 2 and 4 were the control groups and received anticoccidials. The prophylactic efficacy of A. annua against coccidiosis was evaluated by recording the weight gain, feed conversion rate, number of oocysts per gram of feces, lesion score, and mortality rate. (3) Results: The chickens fed with A. annua showed a decreasing trend in the number of oocysts per gram of faeces, and their lesion score was 80% lower than in the control group. The weight gains of the chickens treated with A. annua was lower, whilst the feed conversion rate was better than in controls. (4) Conclusions: Artemisia\u00a0annua showed promising results in the prophylaxis of coccidiosis. Overall, the broiler chickens that received A. annua presented promising zootechnical performances and medical data related to coccidiosis and gut microbiota.<\/jats:p>","DOI":"10.3390\/microorganisms10112277","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T03:24:34Z","timestamp":1668655474000},"page":"2277","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of Artemisia annua against Coccidiosis in Broiler Chickens: A Field Trial"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-3343","authenticated-orcid":false,"given":"Mircea","family":"Coroian","sequence":"first","affiliation":[{"name":"Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana Maria","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0795-2410","authenticated-orcid":false,"given":"Virgilia","family":"Popa","sequence":"additional","affiliation":[{"name":"Pasteur Institute, Giulesti, 060269 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsa","family":"Friss","sequence":"additional","affiliation":[{"name":"The Research and Development Station for Cattle Breeding T\u00e2rgu Mures, 547530 S\u00eengeorgiu de Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovidiu","family":"Oprea","sequence":"additional","affiliation":[{"name":"Oprea Avi Com, 547180 Cr\u0103ie\u015fti, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4492-8383","authenticated-orcid":false,"given":"Zsuzsa","family":"Kalm\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"},{"name":"Department of Microbiology, Immunology and Epidemiology, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, 400372 Cluj-Napoca, Romania"},{"name":"ELKH-\u00c1TE Climate Change: New Blood-Sucking Parasites and Vector-Borne Pathogens Research Group, 1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-2070","authenticated-orcid":false,"given":"Adela","family":"Pintea","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biochemistry and Molecular Biology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia-Diana","family":"Bor\u0219an","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viorica","family":"Mircean","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iustina","family":"Lobon\u021biu","sequence":"additional","affiliation":[{"name":"The Research and Development Station for Cattle Breeding T\u00e2rgu Mures, 547530 S\u00eengeorgiu de Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dumitru","family":"Militaru","sequence":"additional","affiliation":[{"name":"Pasteur Institute, Giulesti, 060269 Bucharest, Romania"},{"name":"Department of Parasitology, Faculty of Biotechnology, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 011464 Bucharest, Romania"},{"name":"Academy of Agricultural and Forestry Sciences Gheorghe Ionescu-Sise\u0219ti, 011464 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodica","family":"V\u00e2rban","sequence":"additional","affiliation":[{"name":"Department of Plant Culture, Faculty of Agriculture, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6453-2370","authenticated-orcid":false,"given":"Adriana","family":"Gy\u00f6rke","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2478\/jvetres-2020-0067","article-title":"Efficacy of natural formulations in bovine mastitis pathology: Alternative solution to antibiotic treatment","volume":"64","author":"Dezmirean","year":"2020","journal-title":"J. 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