{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:32:39Z","timestamp":1780396359652,"version":"3.54.1"},"reference-count":77,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German National Cohort (NAKO)","award":["01ER1301A\/B\/C"],"award-info":[{"award-number":["01ER1301A\/B\/C"]}]},{"name":"German National Cohort (NAKO)","award":["01ER1511D"],"award-info":[{"award-number":["01ER1511D"]}]},{"name":"German National Cohort (NAKO)","award":["RA-285\/19"],"award-info":[{"award-number":["RA-285\/19"]}]},{"name":"Federal Ministry of Education and Research (BMBF), the federal states, and the Helmholtz Association","award":["01ER1301A\/B\/C"],"award-info":[{"award-number":["01ER1301A\/B\/C"]}]},{"name":"Federal Ministry of Education and Research (BMBF), the federal states, and the Helmholtz Association","award":["01ER1511D"],"award-info":[{"award-number":["01ER1511D"]}]},{"name":"Federal Ministry of Education and Research (BMBF), the federal states, and the Helmholtz Association","award":["RA-285\/19"],"award-info":[{"award-number":["RA-285\/19"]}]},{"name":"Initiative and Networking Fund of the Helmholtz Association","award":["01ER1301A\/B\/C"],"award-info":[{"award-number":["01ER1301A\/B\/C"]}]},{"name":"Initiative and Networking Fund of the Helmholtz Association","award":["01ER1511D"],"award-info":[{"award-number":["01ER1511D"]}]},{"name":"Initiative and Networking Fund of the Helmholtz Association","award":["RA-285\/19"],"award-info":[{"award-number":["RA-285\/19"]}]},{"name":"intramural funds of the Helmholtz Centre for infection (HZI)","award":["01ER1301A\/B\/C"],"award-info":[{"award-number":["01ER1301A\/B\/C"]}]},{"name":"intramural funds of the Helmholtz Centre for infection (HZI)","award":["01ER1511D"],"award-info":[{"award-number":["01ER1511D"]}]},{"name":"intramural funds of the Helmholtz Centre for infection (HZI)","award":["RA-285\/19"],"award-info":[{"award-number":["RA-285\/19"]}]},{"name":"Life Science Stiftung (LSS)","award":["01ER1301A\/B\/C"],"award-info":[{"award-number":["01ER1301A\/B\/C"]}]},{"name":"Life Science Stiftung (LSS)","award":["01ER1511D"],"award-info":[{"award-number":["01ER1511D"]}]},{"name":"Life Science Stiftung (LSS)","award":["RA-285\/19"],"award-info":[{"award-number":["RA-285\/19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Lyme borreliosis is the leading tick-related illness in Europe, caused by Borrelia Burgdorferi s.l. Lower Saxony, Germany, including its capital, Hanover, has a higher proportion of infected ticks than central European countries, justifying a research focus on the potential human consequences. The current knowledge gap on human incident infections, particularly in Western Germany, demands serological insights, especially regarding a potentially changing climate-related tick abundance and activity. We determined the immunoglobulin G (IgG) and immunoglobulin M (IgM) serostatuses for 8009 German National Cohort (NAKO) participants from Hanover, examined in 2014\u20132018. We used an enzyme-linked immunosorbent assay (ELISA) as the screening and a line immunoblot as confirmation for the Borrelia Burgdorferi s.l. antibodies. We weighted the seropositivity proportions to estimate general population seropositivity and estimated the force of infection (FOI). Using logistic regression, we investigated risk factors for seropositivity. Seropositivity was 3.0% (IgG) and 0.9% (IgM). The FOI varied with age, sharply increasing in participants aged \u226540 years. We confirmed advancing age and male sex as risk factors. We reported reduced odds for seropositivity with increasing body mass index and depressive symptomatology, respectively, pointing to an impact of lifestyle-related behaviors. The local proportion of seropositive individuals is comparable to previous estimates for northern Germany, indicating a steady seroprevalence.<\/jats:p>","DOI":"10.3390\/microorganisms10112286","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T03:35:23Z","timestamp":1668742523000},"page":"2286","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Seroepidemiology of Borrelia burgdorferi s.l. among German National Cohort (NAKO) Participants, Hanover"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5977-388X","authenticated-orcid":false,"given":"Max","family":"Hassenstein","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany"},{"name":"PhD Programme \u201cEpidemiology\u201d Braunschweig-Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3961-3237","authenticated-orcid":false,"given":"Irina","family":"Janzen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany"},{"name":"German Center for Infection Research (DZIF), Braunschweig, Germany"},{"name":"Hanover Medical School (MHH), 30625 Hannover, Germany"},{"name":"TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture of the Hannover Medical School and Helmholtz Centre for Infection Research, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-0103","authenticated-orcid":false,"given":"Manuela","family":"Harries","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Melhorn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany"},{"name":"German Center for Infection Research (DZIF), Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kerrinnes","sequence":"additional","affiliation":[{"name":"Department of RNA-Biology of Bacterial Infections, Helmholtz Institute for RNA-Based Infection Research, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Kemmling","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany"},{"name":"German Center for Infection Research (DZIF), Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Castell","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany"},{"name":"German Center for Infection Research (DZIF), Braunschweig, Germany"},{"name":"TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture of the Hannover Medical School and Helmholtz Centre for Infection Research, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16090","DOI":"10.1038\/nrdp.2016.90","article-title":"Lyme borreliosis","volume":"2","author":"Steere","year":"2016","journal-title":"Nat. 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